blank LMU M;uuml;nchen The Hoffmann-Röder Group- Novel Glycoconjugates and functionalized Biomolecules
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[49] Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, and David J. Hodson, Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology; ACS Cent Sci. 2018, Article ASAP; DOI: 10.1021/acscentsci.7b00237.
[48] Ralph Krafczyk, Jakub Macošek, Pravin Kumar Ankush Jagtap, Daniel Gast, Swetlana Wunder, Prithiba Mitra, Amit Kumar Jha, Jürgen Rohr, Anja Hoffmann-Röder, Kirsten Jung, Janosch Hennig, Jürgen Lassak, Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P; mBio 2017, 8 (5), e01412-17; DOI: 10.1128/mBio.01412-17.
[47] Tom Podewin, Johannes Broichhagen, Christina Frost, Dieter Groneberg, Julia Ast, Helena Meyer-Berg, Nicholas H. F. Fine, Andreas Friebe, Martin Zacharias, David J. Hodson, Dirk Trauner and Anja Hoffmann-Röder, Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone; Chem. Sci. 2017, 8, 4644-4653; DOI: 10.1039/c6sc05044a.
[46] Amrei Deutsch, Christoph Jessen, Carl Deutsch, Konstantin Karaghiosoff, Anja Hoffmann-Röder, One-Pot Synthesis of Substituted trifluoromethylated 2,3-Dihydro-1H-Imidazoles; Org. Lett. 2016, 18, 3474-3477; DOI: 10.1021/acs.orglett.6b01672.
[45] Markus Daum, Frederik Broszeit, Anja Hoffmann-Röder, Synthesis of a Fluorinated Sialophorin Hexasaccharide-Threonine Conjugate for Fmoc Solid-Phase Glycopeptide Synthesis; Eur. J. Org. Chem. 2016, 3709-3720; DOI: 10.1002/ejoc.201600523. Artwork featured on the front cover.
[44] Amrei Deutsch, Christian Wagner, Carl Deutsch, Anja Hoffmann-Röder, Convenient access to di- and trifluoroethylamines for lead structure research; Eur. J. Org. Chem. 2016, 930‒945; DOI: 10.1002/ejoc.201501576. Artwork featured on the front cover.
[43] Swetlana Wunder, Amrei Deutsch, Carl Deutsch, Anja Hoffmann-Röder, One-Pot Synthesis of Functionalized β-Fluoroalkylated Mannich-Type Products from N-Aryl N,O-Acetals; Synthesis 2016, 48; 1167-1176; DOI: 10.1005/s-0035-1561324. Artwork featured on the front cover.
[42] Johannes Broichhagen, Tom Podewin, Helena Meyer-Berg, Yorrick von Ohlen, Natalie R. Johnston, Ben J. Jones, Stephen R. Bloom, Guy A. Rutter, Anja Hoffmann-Röder, David J. Hodson, Dirk Trauner, Optical control of insulin secretion using an incretin switch; Angew. Chem. Int. Ed. 2015, 54, 15565‒15569; DOI: 10.1002/anie.201506384.
[41] Tom Podewin, Michael S. Rampp, Ilvana Turkanovic, Konstantin L. Karaghiosoff, Wolfgang Zinth and Anja Hoffmann-Röder, Photocontrolled chignolin-derived β-hairpin peptidomimetics; Chem. Commun. 2015, 51, 4001‒4004; DOI: 10.1039/C4CC10304A.
[40] Manuel Johannes, Maximilian Reindl, Bastian Gerlitzki, Edgar Schmitt, Anja Hoffmann-Röder, Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4’-deoxy-4’-fluoro-Thomsen–Friedenreich epitope; Beilstein J. Org. Chem. 2015, 11, 155‒161; DOI: 10.3762/bjoc.11.15.
[39] Isabella Tavernaro, Sebastian Hartmann, Laura Sommer, Heike Hausmann, Christian Rohner, Martin Ruehl, Anja Hoffmann-Röder, Sabine Schlecht, Synthesis of tumor-associated MUC1-glycopeptides and their multivalent presentation by functionalized gold colloids; Org. Biomol. Chem. 2015, 13, 81‒97; DOI: 10.1039/C4OB01339E.
[38] Martin Scherer, Patrick Scheibe, Jérôme Schoenhentz, Anja Hoffmann-Röder, Rudolf Zentel, Patterned monomolecular films from polymerizable and fluorinated lipids for the presentation of glycosylated lipids; Colloid Polym. Sci. 2014; 292, 1803-1815; DOI: 10.1007/s00396-014-3237-5.
[37]
Timo Schüler, Jochen Renkel, Stephan Hobe, Moritz Susewind, Dorrit E. Jacob, Martin Panthöfer, Anja Hoffmann-Röder, Harald Paulsen, Wolfgang Tremel, Designed Peptides for Biomineral Polymorph, Recognition: A Case Study for Calcium Carbonate; J. Mater. Chem. B 2014, 2, 3511-3518; DOI: 10.1039/C4TB00160E.
[36]
Maximilian Reindl, Anja Hoffmann-Röder, Antibody Recognition of Fluorinated Haptens and Antigens; Curr. Topics Med. Chem. 2014, 14, 840-854,
[35] Amrei Deutsch, Herbert Glas, Anja Hoffmann-Röder, Carl Deutsch, Synthesis of functionalized a-trifluoroethylamine scaffolds via Grignard addition to N-aryl hemiaminal ethers; RSC Adv. 20144, 9288−9291; DOI: 10.1039/C3RA47708H.
[34] Thomas Oberbillig, Holger Löwe, Anja Hoffmann-Röder, Synthesis of Fluorinated Glycosyl Amino Acid Building Blocks for MUC1 Cancer Vaccine Candidates by Microreactor-Assisted Glycosylation; J. Flow Chem. 2012, 2, 83−86; DOI: 10.1556/JFC-D-12-00011.
[33] Thomas Oberbillig, Christian Mersch, Sarah Wagner, Anja Hoffmann-Röder, Antibody recognition of fluorinated MUC1 glycopeptide antigens; Chem. Commun. 201248, 1487−1489; DOI: 10.1039/C1CC15139H.
[32] Anja Hoffmann-Röder, Manuel Johannes, Synthesis of a MUC1-glycopeptide-BSA conjugate vaccine bearing the 3-deoxy-3-fluoro-Thomsen-Friedenreich antigen; Chem. Commun. 201147, 9903‒9905; DOI: 10.1039/c1cc13184b.
[31] Tobias Platen, Timo Schüler, Wolfgang Tremel, Anja Hoffmann-Röder, Synthesis and antibody binding of highly fluorinated amphiphilic MUC1 glycopeptide antigens; Eur J. Org. Chem2011, 3878‒3887; DOI: 10.1002/ejoc.201100648.
[30] Manuel Johannes, Thomas Oberbillig, Anja Hoffmann-Röder, Synthesis of fluorinated Thomsen-Friedenreich antigens: direct deoxyfluorination of αGalNAc-threonine tert-butyl esters; Org. Biomol. Chem. 20119, 5541‒5546; DOI: 10.1039/c1ob05373f.
[29]  Anja Hoffmann-Röder, Jérôme Schoenhentz, Sarah Wagner, Edgar Schmitt, Perfluoro­alkylated amphiphilic MUC1 glycopeptide antigens as tools for cancer immunotherapy; Chem. Commun. 201147, 382‒384; DOI: 10.1039/c0cc02250k.
[28]  Anja Hoffmann-Röder, Mirjam Hemmelmann, Patrick Scheibe, Jérôme Schoenhentz, Rudolf Zentel,Supramolekulare Systeme für die Tumorimmuntherapie; Natur & Geist 201026, 38‒41.
[27]  Patrick Scheibe, Jérôme Schoenhentz, Tobias Platen, Anja Hoffmann-Röder, Rudolf Zentel, Langmuir-Blodgett films of fluorinated glycolipids and polymerizable lipids and their phase separating behavior; Langmuir 2010,26, 18246‒18255; DOI: 10.1021/la1029917.
[26]  Anja Hoffmann-Röder, Anton Kaiser, Sarah Wagner, Nikola Gaidzik, Danuta Kowalczyk, Ulrika Westerlind, Edgar Schmitt, Horst Kunz, Synthetische Antitumorvakzine aus Tetanus-Toxoid-Konjugaten von MUC1–Glycopeptiden mit Thomsen-Friedenreich-Antigen und dessen fluorsubstituiertem Analogon; Angew. Chem. 2010122, 8676‒8681; DOI: 10.1002/ange.201003810Angew. Chem. Int. Ed201049, 8498‒8503; DOI: 10.1002/anie.201003810.
[25]  Sarah Wagner, Christian Mersch, Anja Hoffmann-Röder, Fluorinated glycosyl amino acids for mucin-like glycopeptide antigen analogues; Chem. Eur. J. 201016, 7319‒7330; DOI: 10.1002/chem.200903294.
[24]  Florian Karch, Anja Hoffmann-Röder, Synthesis of glycosylated β3-homo-threonine conjugates for mucin-like glycopeptide antigen analogues; Beilstein J. Org. Chem. 20106, No 47; DOI: 10.3762/bjoc.6.47.
[23]  Christian Mersch, Sarah Wagner, Anja Hoffmann-Röder, Synthesis of fluorinated analogues of tumor-associated carbohydrate and glycopeptide antigens; Synlett 2009, 2167‒2171; DOI: 10.1055/s-0029-1217566.
[22]  Frank Volz, Sipke H. Wadman, Anja Hoffmann-Röder, Norbert Krause, Gold catalysis in stereoselective natural product synthesis: (+)-linalool oxide, (-)-isocyclocapitelline, and (-)-isochrysotricine“; Tetrahedron 200965, 1902‒1910; DOI: 10.1016/j.tet.2008.11.104.
[21]  Norbert Krause, Volker Belting, Carl Deutsch, Jörg Erdsack, Hong-Tao Fan, Birgit Gockel, Anja Hoffmann-Röder, Nobuyoshi Morita, Frank Volz, Golden opportunities in catalysis; Pure Appl. Chem.200880, 1063‒1069; DOI: 10.1351/pac200880051063.
[20]  Carl Deutsch, Birgit Gockel, Anja Hoffmann-Röder, Norbert Krause, Golden opportunities in stereoselective catalysis: optimization of chirality transfer and catalyst efficiency in the gold-catalyzed cycloisomerization of -hydroxyallenes to 2,5-dihydrofurans; Synlett 2007, 1790‒1794; DOI: 10.1055/s-2007-98256.
[19] Martin Morgenthaler, Eliane Schweizer, Anja Hoffmann-Röder, Fausta Benini, Rainer E. Martin, Georg Jaeschke, Björn Wagner, Holger Fischer, Stefanie Bendels, Daniel Zimmerli, Josef Schneider, François Diederich,Manfred Kansy, Klaus Müller, Predicting and tuning physicochemical properties in lead optimization: amine basicities; ChemMedChem. 20072, 1100‒1115; DOI: 10.1002/cmdc.200700059.
[18]  Carl Deutsch, Anja Hoffmann-Röder, Axel Domke, Norbert Krause, Rapid generation of molecular complexity: synthesis of α-hydroxyallenes using functionalized Grignard reagents; Synlett 2007, 737‒740; DOI: 10.1055/s-2007-970768.
[17]  Eliane Schweizer, Anja Hoffmann-Röder, Jacob A. Olsen, Paul Seiler, Ulrike Obst-Sander, Björn Wagner, Manfred Kansy, David W. Banner, François Diederich,Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors; Org. Biomol. Chem. 20064, 2364‒2375; DOI: 10.1039/b602585d.
[16]  Anja Hoffmann-Röder, Eliane Schweizer, Jonas Egger, Paul Seiler, Ulrike Obst-Sander, Björn Wagner, Manfred Kansy, David W. Banner, François Diederich,Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic Thrombin inhibitors directing fluorinated alkyl groups into the P pocket; ChemMedChem. 20061, 1205‒1215; DOI: 10.1002/cmdc.200600124.
[15]  Eliane Schweizer, Anja Hoffmann-Röder, Kaspar Schärer, Jacob A. Olsen, Christoph Fäh, Paul Seiler, Ulrike Obst-Sander, Björn Wagner, Manfred Kansy, François Diederich,A fluorine scan at the catalytic center of Thrombin: CF, COH, and COMe bioisosterism and fluorine effects on pKa and log D values; ChemMedChem. 20061, 611‒621; DOI: 10.1002/cmdc.200600015.
[14]  Anja Hoffmann-Röder, Norbert Krause,Efficient synthesis of 2-hydroxy-3,4-dienoates by oxidation of zirconiumallenyl enolates with dimethyldioxirane; Synthesis 2006, 2143‒2146; DOI: 10.1055/s-2006-942409.
[13]  Anja Hoffmann-Röder, Norbert Krause, The golden gate to catalysis; Org.Biomol. Chem. 20053, 387‒391; DOI: 10.1039/b416516k.
[12]  Anja Hoffmann-Röder, Paul Seiler, François Diederich,Nucleophilic trifluoromethylation of cyclic imides using (trifluoromethyl)trimethylsilane CF3SiMe3; Org. Biomol. Chem. 20042, 2267‒2269; DOI: 10.1039/b407555b.
[11]  Anja Hoffmann-Röder, Norbert Krause, Synthese und Eigenschaften allenischer Natur- und Wirkstoffe; Angew. Chem. 2004116, 1216‒1236; DOI: 10.1002/ange.200300628.; Angew. Chem. Int. Ed. 200443, 1196‒1216; DOI: 10.1002/anie.200300628.
[10]  Norbert Krause, Anja Hoffmann-Röder, Synthesis of allenes with organometallic reagents; Tetrahedron 200460, 11671‒11694; DOI: 10.1016/j.tet.2004.09.094.
[9]  Norbert Krause, Anja Hoffmann-Röder, Allenic natural products and pharmaceuticals, in: Modern Allene Chemistry; (N. Krause, A. S. K. Hashmi, Eds.), Wiley-VCH, Weinheim2004, 997‒1040; DOI: 10.1002/9783527619573.ch18.
[8]  Anja Hoffmann-Röder Norbert Krause, Metal-mediated synthesis of allenes in: Modern Allene Chemistry; (N. Krause, A. S. K. Hashmi, Eds.), Wiley-VCH, Weinheim2004, 51‒92; DOI: 10.1002/9783527619573.ch2.
[7]  Norbert Krause, Anja Hoffmann-Röder, Copper-mediated addition and substitution reactions of extended multiple bond system in: Modern Organocopper Chemistry; (N. Krause, Ed.), Wiley-VCH, Weinheim2002, S.145‒166.
[6]  Anja Hoffmann-Röder, Norbert Krause,Enantioselektive Synthese von und mit Allenen; Angew. Chem. 2002114, 3057‒3059; DOI: 10.1002/1521-3757(20020816)114:16<3057::AID-ANGE3057>3.0.CO;2-S.; Angew. Chem. Int. Ed. 200241, 2933‒2935.
[5]  Anja Hoffmann-Röder, Norbert Krause,Synthesis of highly functionalized propargylic alcohols: direct addition of epoxy acetylides to aldehydes and ketones; Helv. Chim. Acta 200285, 3176‒3184; DOI: 10.1002/1522-2675(200210)85:10<3176::AID-HLCA3176>3.0.CO;2-7.
[4]  Norbert Krause, Anja Hoffmann-Röder, Johannes Canisius,From amino acids to dihydrofurans: functionalized allenes in modern organic synthesis; Synthesis 2002, 1759‒1774; DOI: 10.1055/s-2002-33707.
[3]  Norbert Krause, Anja Hoffmann-Röder,Recent advances in catalytic enantioselective michael additions (review); Synthesis 2001, 171‒196; DOI: 10.1055/s-2001-10803.
[2]  Anja Hoffmann-Röder, Norbert Krause,Gold(III)-chloride catalyzed cyclization of hydroxyallenes to 2,5-dihydrofurans; Org. Lett. 20013, 2537‒2538; DOI: 10.1021/ol016205+.
[1]  Norbert Krause, Michael Laux, Anja Hoffmann-Röder,New methods for the stereoselective synthesis of 2-hydroxy-3,4-dienoates and functionalized 2,5-dihydrofurans; Tetrahedron Lett. 200041, 9613‒9616; DOI: 10.1055/s-2006-942409.