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Publications

  1. R. Linser, V. Chevelkov, A. Diehl, B. Reif, “Sensitivity Enhancement Using Paramagnetic Relaxation in MAS Solid-State NMR of Perdeuterated Proteins”, J. Magn. Reson. 189, 209–216 (2007).
  2. R. Linser, U. Fink, B. Reif, “Proton-Detected Scalar Coupling Based Assignment Strategies in MAS Solid-State NMR Spectroscopy Applied to Perdeuterated Proteins”, J. Magn. Reson. 193, 89–93 (2008).
  3. A. Krushelnitsky, E. de Azevedo, R. Linser, B. Reif, K. Saalwaechter, D. Reichert, “Direct Observation of Millisecond to Second Motions in Proteins by Dipolar CODEX NMR”, J. Am. Chem. Soc. 131, 12097–12099 (2009).
  4. R. Linser, U. Fink, B. Reif, “Probing Surface Accessibility of Proteins Using Paramagnetic Relaxation in MAS solid-state NMR Spectroscopy”, J. Am. Chem. Soc. 131 (38), 13703–13708 (2009).
  5. Ü. Akbey, S. Lange, W. T. Franks, R. Linser, K. Rehbein, A. Diehl, B. J. van Rossum, B. Reif, H. Oschkinat, „Optimum Levels of Exchangeable Protons in Perdeuterated Proteins for Proton Detection in MAS Solid-State NMR Spectroscopy“, J. Biomol. NMR 46, 67–73 (2009).
  6. R. Linser, U. Fink, B. Reif, “Narrow Carbonyl Linewidths of Proton-Diluted Proteins Facilitate NMR Assignments in the Solid State”, J. Biomol. NMR 47 (1), 1–6 (2010).
  7. V. Agarwal, R. Linser, U. Fink, K. Fälber, B. Reif, „Identification of Hydroxyl Protons and Characterization of Exchange Behaviour and Hydrogen Bonding in a Microcrystalline Protein”, J. Am. Chem. Soc. 132 (9), 3187–3195 (2010).
  8. V. Chevelkov, Y. Xue, R. Linser, N. Skrynnikov, B. Reif, „Comparison of Solid-State Dipolar Couplings and Solution Relaxation Data Provides Insight into Protein Backbone Dynamics”, J. Am. Chem. Soc. 132 (14), 5015–5017 (2010).
  9. R. Linser, U. Fink, B. Reif, “Detection of dynamic regions in biological solids enabled by spin-state selective NMR experiments”, J. Am. Chem. Soc. 132 (26), 8891–8893 (2010).
  10. * R. Linser, “MAS Solid-State NMR on Biomolecules: Development and Application of New Methodology”, Südwestdeutscher Verlag für Hochschulschriften AG Co. KG, Saarbrücken, ISBN-13: 9783838125480.
  11. * R. Linser, B. Bardiaux, V. Higman, U. Fink, B. Reif, “Structure Calculation from Unambiguous Long-Range Amide and Methyl 1H−1H Distance Restraints for a Microcrystalline Protein with MAS Solid-State NMR Spectroscopy”, J. Am. Chem. Soc. 133 (15), 5905–5912 (2011).
  12. R. Linser, M. Dasari, U. Fink, P. Schmieder, J.-M. Lopez del Amo, S. Marcovic, M. Hiller, H. Oschkinat, D. Oesterheld, B. Reif, “Proton detected solid state NMR of fibrillar and membrane proteins”, Angew. Chem., Int. Ed. 50 (19), 4508–4512 (2011);
    Cover, Angew. Chem. Int. Ed. 50 (19), 4237 (2011).

    R. Linser, M. Dasari, U. Fink, P. Schmieder, J.-M. Lopez del Amo, S. Marcovic, M. Hiller, H. Oschkinat, D. Oesterheld, B. Reif, “Festkörper-NMR-Spektroskopie mit Protonendetektion an fibrillären Proteinen und Membranproteinen”, Angew. Chem. 123 (19), 4601–4605 (2011);
    Cover, Angew. Chem. 123 (19), 4325 (2011).
  13. * R. Linser, “Sidechain to backbone correlation in perdeuterated proteins through combined excitation and long-range magnetization transfer.”, J. Biomol. NMR 51 (3), 221–226 (2011).
  14. R. L. Holmes, J. A. Campbell, R. Linser, J. M. Hook, R. P. Burford, “In-situ preparation of poly(2-hydroxyethyl methacrylate)-titania hybrids using γ-radiation”, Polymer 52 (20), 4471–4479 (2011).
  15. * R. Linser, “Backbone Assignment of Perdeuterated Proteins Using Long-Range H/C-Dipolar Transfers”, J. Biomol. NMR 52 (2), 151–158 (2012).
  16. V. Morris, R. Linser†, K. L. Wilde, A. P. Duff, M. Sunde, A. Kwan, “Solid-state NMR spectroscopy of functional amyloid from a fungal hydrophobin: A well-ordered β-sheet core amidst structural heterogeneity”, Angew. Chem. Int. Ed. 51 (50), 12621–12625 (2012).
    († Shared first-authorship.)

    V. Morris, R. Linser †, K. L. Wilde, A. P. Duff, M. Sunde, A. Kwan, “Festkörper-NMR-Spektroskopie an funktionellen Amyloiden eines Pilz-Hydrophobins: Hinweise auf einen geordneten β-Faltblattkern bei genereller struktureller Heterogenität“, Angew. Chem. 124 (50), 12791–12795 (2012). († Shared first-authorship.)
  17. V. Agarwal, R. Linser, M. Dasari, U. Fink, J.-M. Lopez Del Amo, B. Reif, “Hydrogen bonding involving side chain exchangeable groups stabilizes amyloid quarternary structure.” Phys. Chem. Chem. Phys. 15, 12551–12557 (2013).
  18. A. Mainz, T. Religa, R. Sprangers, R. Linser, L. E. Kay, B. Reif, “NMR spectroscopy of soluble protein complexes at one mega-dalton and beyond”, Angew. Chem. Int. Ed. 52 (33), 8746–8751 (2013).

    A. Mainz, T. Religa, R. Sprangers, R. Linser, L. E. Kay, B. Reif, “NMR-Spektroskopie an löslichen Proteinkomplexen mit Molekulargewicht im Mega-Dalton-Bereich”, Angew. Chem. 125 (33), 8909–8914 (2013).
  19. S. M. F. Rabbi, R. Linser, J. M. Hook, B. R. Wilson, P. V. Lockwood, H. Daniel, I. M. Young, “Characterization of soil organic matter in aggregates and size-density fractions by solid state 13C CPMAS NMR spectroscopy”, Commun. Soil Sci. Plan. 45 (11) 1523–1537 (2014).
  20. R. Linser, R. Sarkar, A. Krushelnitzky, A. Mainz, B. Reif, “Dynamics in the Solid State: Perspectives for the Investigation of Amyloid Aggregates, Membrane Proteins, and Soluble Protein Complexes”, J. Biomol. NMR 59 (1), 1–14 (2014).
  21. * R. Linser, V. Gelev, F. Hagn, S. G. Hyberts, H. Arthanari, G. Wagner, “Selective methyl labeling of eukaryotic membrane proteins using cell-free expression”, J. Am. Chem. Soc. 136 (32), 11308–11310 (2014),
    Cover: J. Am. Chem. Soc., 2014, 136 (32), front page.
    Spotlights article: J. Am. Chem. Soc., 2014, 136 (32), 11197.
  22. C. H. Chia, S. D. Joseph, A. Rawal, R. Linser, J. M. Hook, P. Munroe, “Microstructural Characterization of White Charcoal”, J. Anal. Appl. Pyrol. 109, 215-221 (2014).
  23. A. Trebugov†, R. Linser†, K. Q. Vuong, A. Rawal, J. Gehman, B. Messerle, “Solid-State NMR Structure Characterization of a 13CO-Labeled Ir(I) Complex with a P,N‑Donor Ligand Including Ultrafast MAS Methods”, Inorg. Chem. 53, 7146−7153 (2014).
    († Shared first-authorship)
  24. * R. Linser, B. Bardiaux, S. G. Hyberts, A. Kwan, V. Morris, M. Sunde, G. Wagner, “Solid-State NMR Structure Determination from Diagonal-Compensated, Sparsely Nonuniform-Sampled 4D Proton–Proton Restraints”, J. Am. Chem. Soc. 136 (31), 11002–11010 (2014).
  25. S. Roy, K. C. Mondal, L. Krause, P. Stollberg, R. Herbst-Irmer, D. Stalke, J. Meyer, A. C. Stückl, B. Maity, D. Koley, S. K. Vasa, S. Q. Xiang, R. Linser, H. W. Roesky, “Electron-Induced Conversion of Silylones to Six-membered Cyclic Silylenes”, J. Am. Chem. Soc., 136 (48), 16776–16779 (2014).
  26. * S. Xiang, K. Grohe, P. Rovó, S. K. Vasa, K. Giller, S. Becker, R. Linser, “Sequential backbone assignment based on direct amide-to-amide correlation experiments”, J. Biomol. NMR, 62 (3), 303–311 (2015).
  27. S. Roy, B. Dittrich, T. Mondal, D. Koley, A. C. Stückl, B. Schwederski, W. Kaim, M. John, S. K. Vasa, R. Linser, H. Roesky, “Carbene Supported Dimer of Heavier Ketenimine Analogue with P and Si Atoms”, J. Am. Chem. Soc., 137 (19), 6180–6183 (2015).
  28. K. C. Mondal, S. Roy, B. Dittrich, D. Koley, B. Maity, S. Dutta, R. Linser, S. K. Vasa, S. Dechert, H. Roesky, “A Soluble Molecular Variant of the Semiconducting Silicondiselenide”, Chem. Sci., 6, 5230–5234 (2015).
  29. * N. Kulminskaya, S. K. Vasa, K. Giller, S. Becker, R. Linser, “Asynchronous through-bond homonuclear isotropic mixing: Application to carbon-carbon transfer in perdeuterated proteins under MAS”, J. Biomol. NMR, 63 (3), 245-253 (2015).
  30. * R. Linser, N. Salvi, R. Briones, P. Rovó, B. de Groot, G. Wagner,The Membrane Anchor of the Transcriptional Activator SREBP is Characterized by Intrinsic Conformational Flexibility”, Proc. Natl. Acad. Sci. USA, 112 (40) 12390-12395 (2015).
  31. * P. Rovó, K. Grohe, K. Giller, S. Becker, R. Linser, “Proton Transverse Relaxation as a Sensitive Probe for Structure Determination in Solid Proteins”, ChemPhysChem,, 16 (18), 3791–3796 (2015).
    Cover: ChemPhysChem, 16 (18), 3739 (2015).
    ”Cover Profile” article: ChemPhysChem, 16 (18), 3743 (2015).
  32. * N. Kulminskaya, S. K. Vasa, K. Giller, S. Becker, A. Kwan, M. Sunde, R. Linser, “Access to side-chain carbon information in deuterated solids under ultra-fast MAS through non-rotor-synchronized mixing”, ChemComm, 52 (2), 268-271 (2016).
    Back cover feature: ChemComm, 52 (2), 419 (2016).
  33. * S. K. Vasa, P. Rovó, K. Giller, S. Becker, R. Linser,Access to Aliphatic Protons as Reporters in Non-Deuterated Proteins by Second-Order Transfer”, PhysChemChemPhys, 18, 8359 – 8363 (2016).
    Back cover: PhysChemChemPhys 18, 8754 (2016).
  34. J. I. Schweizer, M. G. Scheibel, M. Diefenbach, F. Neumeyer, C. Würtele, N. Kulminskaya, R. Linser, N. Auner, S. Schneider, M. C. Holthausen, “A Disilene Base Adduct with a Dative Si–Si Single Bond”, Angew. Chem., Int. Ed., 55 (5), 1782-1786 (2016).
  35. * S. Xiang, J. Biernat, E. Mandelkow, S. Becker, R. Linser, “Backbone assignment for minimal protein amounts of low structural homogeneity in the absence of deuteration”, Chem. Commun., 52, 4002-4005 (2016).
    Cover: Chem. Commun., 52, 3979-3979 (2016)
  36. I. Gonzalo-Juan, D. U. Tulyaganov, C. Balan, R. Linser, J. M. F. Ferreira, R. Riedel, E. Ionescu, “Tailoring the viscoelastic properties of injectable biocomposites: A spectroscopic assessment of the interactions between organic carriers and bioactive glass particles”, Mater. Design, 97, 45-50 (2016).
  37. * R. Linser, “Michael L. Johns, Einar O. Fridjonsson, Sarah Vogt, and Agnes Haber (Eds.): Mobile NMR and MRI. Developments and applications.” , Anal. Bioanal. Chem. Anal. Bioanal. Chem. 408 (15), 3929-3931 (2016).
  38. * R. Linser, “Protons as sensitive reporters for molecular details.”, in the research report of the Max Planck Society (2016).
  39. J. Cramer, J. Schiebel, T. Wulsdorf, K. Grohe, E. E. Najbauer, F. R. Ehrmann, N. Radeva, N. Zitzer, U. Linne, R. Linser, A. Heine, G. Klebe, “A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red Herring”, Angew. Chem., Int. Ed., 56 (7), 1908–1913 (2017),

    J. Cramer, J. Schiebel, T. Wulsdorf, K. Grohe, E. E. Najbauer, F. R. Ehrmann, N. Radeva, N. Zitzer, U. Linne, R. Linser, A. Heine, G. Klebe, “Falsch-positiver Treffer im Fragment-basierten Wirkstoffdesign: Lass Dich nicht auf die falsche Fährte locken!”, Angew. Chem., 129 (7), 1934–1940 (2017).
  40. * S. Xiang, N. Kulminskaya, B. Habenstein, J. Biernat, K. Tepper, M. Paulat, C. Griesinger, S. Becker, A. Lange, E. Mandelkow, R. Linser, “A two-component adhesive: Tau fibrils arise from a combination of a well-defined motif and conformationally flexible interactions”, J. Am. Chem. Soc., 139, 2639−2646 (2017).
  41. G. Jaipuria, A. Leonov, K. Giller, S. K. Vasa, L. Jaremko, M. Jaremko, R. Linser, S. Becker, M. Zweckstetter, “Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure”, Nature Comm. 8, 14893 (2017).
  42. * K. Grohe, K. Tekwani Movellan, S. K. Vasa, K. Giller, S. Becker, R. Linser, “Non-equilibrium hydrogen exchange for determination of H-bond strength and water accessibility in solid proteins”, J. Biomol. NMR, 68 (1), 7-17 (2017).
  43. D. F. Gauto, A. Hessel, P. Rovó, V. Kurauskas, R. Linser, P. Schanda, “Protein conformational dynamics studied by 15N and 1H R1ρ relaxation dispersion: Application to wild-type and G53A ubiquitin crystals”, Solid State Nucl. Mag., just accepted, 87, 86-95 (2017).
  44. * P. Rovó, R. Linser, “Microsecond timescale proton rotating-frame relaxation under magic angle spinning”, J. Phys Chem. 121 (25), 6117–6130 (2017).
  45. D. Fischer, A. von Mankowski, A. Ranft, S. K. Vasa, R. Linser, J. Mannhart, B. V. Lotsch, “ZIF‑8 films prepared by femtosecond pulsed-laser-deposition”, Chem. Mater., 29 (12), 5148–5155 (2017).
  46. * R. Linser, “Solid-state NMR spectroscopic trends for supramolecular assemblies and protein aggregates”, invited “Trends” article in Solid state Nucl. Magn. Res., 87:45-53 (2017).
  47. P. Rovó, R. Linser, “Microsecond timescale solid-state backbone dynamics: a combined NMR approach”, accepted in ChemPhysChem, DOI: 10.1002/cphc.201701238 (2017).