Curriculum Vitae PD Dr Manfred Ogris
Scientific Career
| 1989 -1996 | Diploma study (Austrian diploma) of Biotechnology at the University of Agricultural Sciences (BOKU) in Vienna, Austria |
| 1995 -1996 | Diploma at the Vienna biocenter in the group of Dr. E. Wagner: 'Structures of DNA-polylysine complexes and their influence on gene transfer' |
| 1996 - 1999 | Ph.D. work at the Vienna Biocenter in the group of Dr. E. Wagner: 'Structure and biological properties of DNA-polycation complexes' |
| 1999 - Oct 2000 | Postdoctoral research fellow, CRC Institute for Cancer Research in Birmingham/UK |
| Nov 2000 - May 2001 | Marie Curie Fellow, CRC Institute for Cancer Research in Birmingham/UK |
| Since June 2001 | Groupleader Vectorology, Chair of Pharmaceutical Biology-Biotechnology, Centre of Drug Research, LMU Munich, Germany |
| 2001-2007 | Akademischer Rat (since 2004 tenure) |
| since 2007 | Akademischer Oberrat (tenure) |
| 2009 | Habilitation in Pharmaceutical Biology and Pharmaceutical Biotechnology |
| 2012 | Full professorship in Pharmaceutical Sciences offered by the University of Vienna |
Memberships
Deutsche Gesellschaft für Gentherapie (DGGT)
European Society for Gene and Cell Therapy (ESGCT)
Editorial Activities
| Since 2006 | Editorial board of ‚Recent Patents on Drug Delivery & Formulation’ |
| Since 2009 | Associate editor of 'Therapeutic Delivery' |
Grants / Funds
| 2000-2001 | Marie Curie Individual Fellowship (Category 30) Proposal No. MCFI-2000-00509 'Development of triggered endosomolysis mechanism for improved gene therapy' CRC Institute for Cancer Studies, Birmingham, UK duration: 24 months |
| 2004-2006 | Wilhelm-Sander Stiftung (Germany), 'Hochwirksame lokale Chemotherapie nach tumorgerichtetem Gentransfer in vivo' |
| 2004-2007 | Impuls- und Vernetzungsfonds der Helmholtz-Gemeinschaft Deutscher Forschungszentren, 'Clinical Hyperthermia and Related Technology' |
| 2005-2006 | Deutscher Akademischer Austauschdienst (DAAD), 'Non-viral Phosphorus-containing Gene-Transfer Vectors for Systemic Tumor Targeting' |
| Since 2006 | DFG research network SPP1230 (Gene therapy – vector safety) |
| 2007 | DFG: Forschungsaufenthalt Prof Kolio Troev (Institute of Polymers, Bulgarian Academy of Sciences) DFG |
| 2008-2011 | DFG Sachbeihilfe: Optimierung und therapeutische Anwendung tumorselektiver siRNA Formulierungen gegen Komponenten des Wnt-Signalwegs in gastrointerstinalen Tumormodellen |
| since 2009 | DFG Collaborative research center SFB 824 "Imaging for the Selection, Monitoring and Individualisation of Cancer Therapy": Project ‘Tumor specific molecularly targeted therapy using the sodium iodide symporter as reporter and therapy gene’ (together with Prof Christine Spitzweg, Klinikum Großhadern) |
| 2011 |
Center for NanoScience research collaboration grant ‘Polymer coated Adenovirus for cancer gene therapy – correlating ultrastructure with biological activity’ (together with Prof Christina Scheu, Department of Chemistry, LMU) |
| 2011-2012 |
Bayerische Forschungsstiftung: PostDoc research fellowship for Dr Joana Viola (PDOC 78-11): ’ Development of a tailored non-viral gene delivery system directed to advanced melanoma.’ |
| 2012 |
BMBF grant 01EU1202 |
| 2012 |
Center for NanoScience research collaboration grant ‘Covalent vs non-covalent dendrimer coating of Adenovirus: Implications on ultrastructure and transgene expression’ (together with Prof Christina Scheu, Department of Chemistry, LMU) |
| 2012-2017 |
Innovative Medicines Initiative (IMI) collaborative research project COMPACT (Collaboration on the Optimisation of Macromolecular Pharmaceutical Access to Cellular Targets), partner 9 |
Patent
E. Wagner, M. Ogris, R. Kircheis, S. Brunner. Complexes for Transporting Nucleic Acid into Eucaryotic Higher-Cells. PCT/EP98/03679
Selected Talks
Coupling of Polyethylenglycol to DNA/Transferrin-Polyethylenimine Complexes for Gene Transfer in vitro and in vivo. 1st Annual Meeting, American Society of Gene Therapy; May 28th - May 31st 1998, Seattle, Washington, USA
Enhanced gene transfer activity of DNA/Polyethylenimine complexes with covalently bound Melittin. 8th Annual Meeting of the European Society for Gene Therapy; October 6th - October 10th 2000, Stockholm, Sweden
Cationic polymers for targeted gene delivery. XVIièmes Journees Scientifiques du GTRV; December 13th - December 14th 2001, Lyon, France
Gentherapie: wann kommt der Durchbruch? Sommerakademie der österreichischen Apothekerkammer, July 2002, Pörtschach, Austria
Tumor targeted gene transfer. International Syposium on Inflammation, Regeneration and Transformation in the Pancreas (SFB 518), October 2002, Ulm, Germany
Tumor Gentherapie mit nicht-viralen Gentransfersystemen. Klinisch-wissenschaftliches Kolloquium der Chirurgischen Klinik, 'Neue Strategien in der Krebsbehandlung: Tumorvakkzinierung und Gentherapie', June 2003, Klinikum Großhadern, München, Germany
Multi parameter analysis with the Cyan MLE: Applications for cell cycle analysis and transfection studies. DakoCytomation European Life Sciences User Group Meeting, September 2003, Paris, France
Membrane-active peptides: Intracellular drug delivery potential. American Association of Pharmaceutical Scientists, Annual Meeting; session 'Membrane Transducing Proteins and Peptides: Implications for Intracellular Drug Delivery', October 2003, Salt Lake City, Utah, USA
Non-viral gene delivery systems - delivery techniques and therapeutic concepts. NATO Advanced Research Workshop; 'Macromolecular approaches to advanced biomaterials engineering systems', November 2003, Sofia, Bulgaria
Multi parameter flow cytometry for gene transfer studies: Tracking artificial viruses outside and inside the cell, Modules de formation pour les étudiants des écoles doctorales - Module 3 La cytométrie en flux et ses applications récentes, Institut Jaques Monod, Université Paris, Jussieu, March 2004, Paris, France
Tumor-targeted delivery with virus-like nucleic acid formulations. Wenner-Gren Foundations International Symposium 'Cell-penetrating peptides and applications', May 2005, Stockholm, Sweden
Tumor-targeted delivery with virus-like nucleic acid formulations. Max-Planck-Institute for Neurobiology, June 2005, Martinsried, Germany
Advances in non-viral vectors. American Association of Pharmaceutical Scientists: Annual Meeting and Exposition, Roundtable Gene Therapy - Chances, Limits and Future November 2005, Nashville, Tennessee, USA
Polyphosphonate based transfection vectors: biophysical and biological evaluation, Institute of Polymers, Aug. 2006, Sofia, Bulgaria
Targeted delivery of nucleic acids to tumors, Scientific and technological developments relevant to the biological and toxin weapon convention. Sept. 2006, London, UK
Importance of plasmid purity for nonviral transfection in vivo with CpG depleted vectors. 1st international workshop on minicircle-DNA. Feb. 2007, Bielefeld, Germany
Advances in cancer therapy: tumor targeted delivery of therapeutic nucleic acids, Institute of Polymers, Dec. 2007, Sofia, Bulgaria
Nanocarrier für die Tumortherapie: Wirksamkeit und Toxizität. Schauplatz NANO, Materialica 2007, München, Germany
Targeting of thermosensitive non-viral gene delivery vectors to tumors with locoregional hyperthermia. 10th international congress on hyperthermic oncology, April 2008, München, Germany
Macromolecular drug carriers for targeting of therapeutic nucleic acids to tumors, IX Congreso de la Sociedad Española de Farmacia Industrial y Galénica, Februar 2009, Pamplona, Navarra, España
Nanocarrier für die Tumortherapie: Wirksamkeit und Toxizität. Seminar ‘Analytik in der Nanotechnologie’, Akademie für Gesundheit und Lebensmittelsicherheit, April 2009, Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Oberschleißheim, Deutschland
Nucleic acid therapeutics – Concepts for targeted delivery to solid tumors. International Workshop on Biomaterials, September 2009, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
Nucleic acid therapeutics – Concepts for targeted delivery to solid tumors. September 2009, Universiteit Gent, Faculteit Farmaceutische Wetenschappen
Physicochemical methods for gene delivery (Part 1). November 2009. Combined Meeting of the 17th European-Society-of-Gene-and-Cell-Therapy/16th German-Society-for-Gene-Therapy/4th German-Society-for-Stem-Cell-Research, Hannover
Synthetic gene delivery systems: from carrier design to therapeutic applications. June 2010, Dipartimento di Chimica e Technologie Farmaceutiche, Facoltà di Farmacia, Università di Palermo
Nonviral gene delivery systems: how to improve efficiency of delivery and transgene expression. September 2010, DG-GT Summer School, Köln
Nanopartikel als Gentransporter. June and September 2011, Bürgerdialog ‘Nano und Medizin’ am Deutschen Museum, München
Targeted synthetic gene vectors for the treatment of metastatic cancer. September 2011, Karolinska Institute, Stockholm
Combinatorial cancer gene therapy with targeted synthetic gene vectors. November 2011, Annual Workshop CRS Italian Chapter; nanostructured devices for drug delivery: from small molecules to biotech drugs, Rome
Generation of a tumor- and tissue-specific episomal non-viral system, March 2012, German Society for Gene Therapy (DG-GT) 18th Annual Meeting, Frankfurt
Can synthetic viral vectors enable gene/nucleic acid delivery? May 2012, 9th International Symposion on Polymer Therapeutics: From Laboratory to Clinical Practice, Centro de Investigación Príncipe Felipe, Valencia, Spain
Publications