On October 1, 2015, we started a project at LMU Munich which is funded by ERC Starting Grant ERC-2014-StG – 637830 "Novel Asthma Therapy" We will develop dry powder platform technologies for pulmonary delivery of siRNA for the targeting of activated T cells.
Participants in the project are currently Prof. Merkel, Dr. Aditi Mehta, Dr. Gabriella Costabile, Mariam Mohammadi, Rima Kandil, and Tobias Keil. Collaborators are Yuran Xie and Daniel Feldmann at Wayne State University.
Our project has a clear potential of advancing pulmonary nanomedicine as novel asthma therapy.
- Daniel P. Feldmann et al., The impact of microfluidic mixing of triblock micelleplexes on in vitro/in vivo gene silencing and intracellular trafficking, Nanotechnology 2017, 28(22), 224001.
- Yuran Xie et al., Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine, Molecules 2016, 21(10), 1334.
- Yuran Xie et al., Targeted Delivery of siRNA to Activated T Cells via Transferrin-Polyethylenimine (Tf-PEI) as a Potential Therapy of Asthma, Journal of Controlled Release, 2016, 229, 120-9.
- Yuran Xie and Olivia Merkel, Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma, Archiv der Pharmazie 2015, 348 (19), 681-688.