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Publications

Original Peer Reviewed Research

Steven K Jones, Anwesha Sarkar, Daniel P Feldmann, Peter Hoffmann, Olivia M Merkel*: Revisiting the value of competition assays in folate receptor-mediated drug delivery.
Biomaterials 2017, 138, 35-34.

Daniel P Feldmann, Yuran Xie, Steven K Jones, Dongyue Yu, Anna Moszczynska, Olivia M Merkel*: The impact of microfluidic mixing of triblock micelleplexes on in vitro/in vivo gene silencing and intracellular trafficking.
Nanotechnology 2017, 28(22), 224001.

Yuran Xie, Bryan Killinger, Anna Moszczynska, Olivia M Merkel*: Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine.
Molecules, 2016, 21 (10), E1334

Mariam Mohammadi, Ying Li, Daniel G Abebe, Yuran Xie, Rima Kandil, Teresa Kraus, Nardhy Gomez-Lopez, Tomoko Fujiwara, Olivia M Merkel*: Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages
Journal of Controlled Release, 2016, doi:10.1016/j.conrel.2016.08.020

Sara Movassaghian, Yuran Xie, Claudia Hildebrandt, Rayna Rosati, Ying Li, Na Hyung Kim, Denise S Conti, Sandro RP da Rocha, Zeng-Quan Yang, Olivia M Merkel*: Post-transcriptional regulation of the GASC1 oncogene with active tumor-targeted siRNA-nanoparticles
Molecular Pharmaceutics, 2016, 13 (8), 2605-21

Qian Zhong, Olivia M Merkel, Joshua J Reineke, Sandro RP da Rocha: Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution.
Molecular Pharmaceutics, 2016, 3 (6), 1886-78

Yuran Xie, Na Hyung Kim, Venkatareddy Nadithe, Dana Schalk, Archana Thakur, Ayşe Kılıç, Lawrence G Lum, David JP Bassett, Olivia M Merkel*: Targeted delivery of siRNA to activated T cells via transferrin-polyethyleneimine (Tf-PEI) as a potential therapy of asthma.
Journal of Controlled Release, 2016, 229, 120-9

Steven K Jones, Vincent Lizzio, Olivia M Merkel*: Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance.
Biomacromolecules, 2016, 17 (1), 76-87

Li Liu, Mengyao Zheng, Damiano Librizzi, Thomas Renette, Olivia M Merkel*, Thomas Kissel: Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI-PCL-PEG-Fol).
Molecular Pharmaceutics, 2016, 13 (1), 134-43

Daniel Ghirmay Abebe, Rima Kandil, Teresa Kraus, Maha Elsayed, Olivia M Merkel*, Tomoko Fujiwara*: Three-Layered Biodegradable Micelles Prepared by Two-Step Self-Assembly of PLA-PEI-PLA and PLA-PEG-PLA Triblock Copolymers as Efficient Gene Delivery System
Macromolecular Bioscience, 2015, 15 (5), 698-717

Venkatareddy Nadithe, Runhui Liu, Na Hyung Kim, Bryan Killinger, Anna Moszczynska, Kristyn S Masters, Samuel H Gellman, Olivia M Merkel*: Screening of Nylon-3 Polymers, a New Class of Cationic Amphiphiles for siRNA Delivery
Molecular Pharmaceutics, 2015, 12 (2), 362-74

R. Michael Dutescu, Claudia Panfil, Olivia M Merkel, Norbert Schrage: Semifluorinated alkanes as liquid drug carrier systemfor topical ocular drug delivery
European Journal of Pharmaceutics and Biopharmaceutics 2014, 88(1), 123–128

Maha Elsayed, Vincent Corrand, Vidula Kolhatkar, Yuran Xie, Na Hyung Kim, Rohit Kolhatkar, Olivia M Merkel: The influence of oligospermine architecture on their suitability for siRNA delivery
Biomacromolecules 2014, 15 (4), 1299-1310

Thomas Endres, Mengyao Zheng, Ayşe Kılıç, Agnieszka Turowska, Moritz Beck-Broichsitter, Harald Renz, Olivia M. Merkel*, Thomas Kissel: Amphiphilic Biodegradable PEG-PCL-PEI Triblock Copolymers for FRET-Capable in Vitro and in Vivo Delivery of siRNA and Quantum Dots
Molecular Pharmaceutics 2014, 11(4), 1273–1281

Agnieszka Turowska, Damiano Librizzi, Nadja Baumgartl, Jens Kuhlmann, Tanja Dicke, Olivia Merkel, Ursula Homburg, Helmut Höffken, Harald Renz, Holger Garn:Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs
Toxicol Appl Pharmacol. 2013 Oct 15;272(2):365-72

Mengyao Zheng, Giovanni M. Pavan, Manuel Neeb, Andreas Schaper, Andrea Danani, Gerhard Klebe, Olivia M. Merkel*, Thomas Kissel: Targeting the blind spot of polycationic nanocarrier-based siRNA delivery
ACS Nano 2012, 6(11), 9447-54

Mengyao Zheng, Damiano Librizzi, Ayşe Kılıç, Yu Liu, Harald Renz, Olivia M. Merkel*, Thomas Kissel: Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers
Biomaterials 2012, 33(27), 6551-8

Thomas Renette, Damiano Librizzi, Thomas Endres, Moritz Beck-Broichsitter, Nadja Bege, Olivia M. Merkel, Holger Petersen, Catherine Curdy, Thomas Kissel:Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy Macromolecular Bioscience 2012, 12(7), 970-8

Olivia M. Merkel and Thomas Kissel: Pulmonary siRNA Delivery
Accounts of Chemical Research 2012, 45(7), 961-70.

Nick D. Weber*, Olivia M. Merkel*, Thomas Kissel, María Angeles Muñoz-Fernández: PEGylated poly(ethylene imine) copolymer-delivered siRNA inhibits HIV replication in vitro
Journal of Controlled Release 2012, 157(1), 55-63

Mengyao Zheng, Yu Liu, Olga Samsonova, Olivia Merkel, Thomas Kissel: Amphiphilic and biodegradable hy-PEI-g-PCL-b-PEG copolymers efficiently mediate transgene expression depending on their graft density
International Journal of Pharmaceutics 2012, 427 (1),80-7

Yu Liu, Olga Samsonova, Brian Sproat, Olivia Merkel, Thomas Kissel: Biophysical characterization of hyper-branched polyethylenimine-graft- polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy- PEI-PCL-mPEG) for siRNA and DNA delivery
Journal of Controlled Release 2011, 153 (3), 262-268

Olga Samsonova, Christian Pfeiffer, Markus Hellmund, Olivia Merkel*, Thomas Kissel: Low molecular weight pDMAEMA-b-pHEMA block-copolymers synthesized via RAFTPolymerization: potential non-viral gene delivery agents?
Polymers 2011, 3, 693-718, *Corresponding Author

Olivia M. Merkel, Rudolf Urbanics, Peter Bedocs, Zoltán Rozsnyay, László Rosivall, Miklós Toth, Thomas Kissel, Janos Szebeni: In vitro and in vivo Complement Activation and Related Anaphylactic Effects Associated with Polyethylenimine and Polyethylenimine-graft-poly(ethylene glycol) Block Copolymers
Biomaterials 2011, 32, 4936-4942

Nadja Bege*, Thomas Renette*, Mirko Jansch, Regina Reul, Olivia Merkel, Holger Petersen, Catherine Curdy, Rainer H. Müller, Thomas Kissel: Poly(ethylene carbonate) nanoparticles: A novel biodegradable carrier system with “stealth” potential
Macromolecular Bioscience 2011, 11 (7), 897-904

Olivia M. Merkel*, Mengyao Zheng, Meredith A Mintzer, Giovanni M Pavan, Damiano Librizzi, Marek Maley, Helmut Höffken, Andrea Danani, Eric E Simanek, Thomas Kissel: Molecular modeling and in vivo imaging can identify
successful flexible triazine dendrimer-based siRNA delivery systems

Journal of Controlled Release 2011, 153 (1), 23-33, *Corresponding Author

Andrea Beyerle, Andrea Braun, Olivia Merkel, Felix Koch, Thomas Kissel, Tobias Stoeger: Comparative in vivo study of poly(ethylene imine)/sirna complexes for pulmonary delivery in mice
Journal of Controlled Release 2011, 151 (1), 51-56

Olivia M. Merkel, Andrea Beyerle, Benedikt Beckmann, Mengyao Zheng, Roland Hartmann, Tobias Stoeger, Thomas Kissel: Polymer-related off-target effects in non-viral siRNA delivery
Biomaterials 2011, 32 (9), 2388-2398

Olivia M. Merkel, Meredith A. Mintzer, Damiano Librizzi, Olga Samsonova, Tanja Dicke, Brian Sproat, Holger Garn, Peter J. Barth, Eric E.Simanek, Thomas Kissel:Triazine dendrimers as non-viral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity
Molecular Pharmaceutics 2010, 7 (4), 969–983

Giovanni M. Pavan, Meredith Mintzer, Eric Simanek, Olivia M. Merkel, Thomas Kissel, Andrea Danani: Computational Insights into the Interactions between DNA and siRNA with “Rigid” and “Flexible” Triazine Dendrimers
Biomacromolecules 2010, 11 (3), 721-30

Andrea Beyerle, Olivia M. Merkel, Tobias Stöger and Thomas Kissel: PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: Structure–function relationships
Toxicology and Applied Pharmacology 2010, 242 (2), 146-154

Olivia M. Merkel*, Meredith A. Mintzer*, Johannes Sitterberg, Udo Bakowsky, Eric E. Simanek and Thomas Kissel: Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity.
Bioconjugate Chemistry 2009, 20 (9), 1799-806

Olivia M. Merkel, Andrea Beyerle, Damiano Librizzi, Andreas Pfestroff, Thomas M. Behr, Brian Sproat, Peter J. Barth, Thomas Kissel: Nonviral siRNA Delivery to the Lung: Investigation of PEG-PEI Polyplexes and Their In Vivo Performance
Molecular Pharmaceutics 2009, 6 (4), 1246-60

Yu Liu, Juliane Nguyen, Terry Steele, Olivia Merkel, Thomas Kissel: A new synthesis method and degradation of hyper-branched polyethylenimine grafted polycaprolactone block mono-methoxyl poly (ethylene glycol) copolymers (hy-PEI-g-PCL-b-mPEG) as potential DNA delivery vectors
Polymer 2009, 50 (16), 3895-3904

Meredith A. Mintzer*, Olivia M. Merkel*, Thomas Kissel, Eric Simanek: Polycationic triazine-based dendrimers: Effect of peripheral groups on transfection efficiency
New J. Chem. 2009, 33, 1918 - 1925
*Both authors contributed equally to this work with synthesis (MAM) and biological and physicochemical characterization (OMM).

Olivia M. Merkel, Oliver Germershaus, Carol K. Wada, Peter J. Tarcha, Thomas Merdan and Thomas Kissel: Integrin alpha-v-beta-3 targeted gene delivery using RGD peptidomimetic conjugates with copolymers of PEGylated poly(ethylene imine)
Bioconjug Chem. 2009, 20 (6), 1270-1280

Olivia M. Merkel, Damiano Librizzi, Andreas Pfestroff, Tino Schurrat, Kevin Buyens, Niek N. Sanders, Stefaan DeSmedt, Martin Béhé and Thomas Kissel: Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
J Control Release 2009, 138 (2), 148-159

Anastasia Malek, Olivia Merkel, Ludger Fink, Frank Czubayko, Thomas Kissel and Achim Aigner: In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes.
Toxicology and applied pharmacology 2009, 236 (1), 97-108

Olivia M. Merkel, Damiano Librizzi, Andreas Pfestroff, Tino Schurrat, Martin Béhé and Thomas Kissel: In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery after novel radio labeling and purification
Bioconjugate Chemistry 2009, 20 (1), 174-182

Juliane Nguyen*, Terry W.J. Steele*, Olivia Merkel, Regina Reul and Thomas Kissel: Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy
Journal of Controlled Release 2008, 132 (3), 243-251

Shirui Mao, Michael Neu, Oliver Germershaus, Olivia Merkel, Johannes Sitterberg, Udo Bakowsky, Thomas Kissel: Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly (ethylene imine)-graft-poly (ethylene glycol) block copolymer/ siRNA polyplexes
Bioconjugate Chem 2006, 17 (5), 1209 -1218

Peer Reviewed Reviews

Steven Jones, Olivia M. Merkel*: Tackling Breast Cancer Chemoresistance with Nano-Formulated siRNA
Nature Gene Therapy, 2016, doi:10.1038/gt.2016.67

Rima Kandil, Olivia M. Merkel*: Therapeutic Delivery of siRNA: Diseases affecting the respiratory system,
Die Pharmazie, 2016, 71 (1), 21-26.

Yuran Xie, Olivia M. Merkel*: Pulmonary Delivery of siRNA via polymeric vectors as therapies of asthma,
Archiv der Pharmazie 2015, 348 (10), 681-688.

Sara Movassaghian, Olivia M. Merkel, Vladimir Torchilin*: Applications of Polymer Micelles for Imaging and Drug Delivery,
WIREs Nanomedicine and Nanobiotechnology 2014, 7 (5), 691-707.

Olivia M. Merkel*, Thomas Kissel: Quo vadis polyplex?, Journal of Controlled Release 2014, 190, 415-23

Olivia M. Merkel*, Israel Rubinstein, Thomas Kissel: siRNA Delivery to the lung: What's new?, Advanced Drug Delivery Reviews 2014, 75:112-28

Maha Elsayed, Olivia M. Merkel*: Nanoimprinting of topographical and 3D cell culture scaffolds, Nanomedicine (London) 2014, 9 (2), 349-366

Na Hyung Kim, Venkatareddy Nadithe, Maha Elsayed, Olivia M. Merkel*: Tracking and treating activated T cells, Journal of Drug Delivery Science and Technology 2013, 23 (1), 17-21

Moritz Beck-Broichsitter, Olivia M. Merkel, Thomas Kissel: Controlled pulmonary drug and gene delivery using polymeric nano-carriers, Journal of Controlled Release 2012, 161(2), 214-24

Olivia M. Merkel, Mengyao Zheng, Heiko Debus, Thomas Kissel: Pulmonary Gene Delivery Using Polymeric Nonviral Vectors, Bioconjugate Chemistry 2012, 23(1), 3-20

Book Chapters and Others

Bettina Schwarz, Olivia M. Merkel, Functionalized PEI and Its Role in Gene Therapy
Material Matters, 2017, 12.2

Rima Kandil, Jon Felt, Prashant Mahajan, Olivia M. Merkel: The Biology and Clinical Treatment of Asthma,
Nanomedicine for Inflammatory Diseases, 2017, CRC Press, pp.217-244.

Yuran Xie, Rima Kandil, Olivia M. Merkel: Bridging the Gap between the Bench and the Clinic: Asthma,
Nanomedicine for Inflammatory Diseases, 2017, CRC Press, pp.255-286.

Daniel G. Abebe, Rima Kandil, Teresa Kraus, Maha Elsayed, Tomoko Fujiwara, Olivia M. Merkel*: Biodegradable Three-Layered Micelles and Injectable Hydrogels, Methods in Molecular Biology 2016, Non-Viral Gene Delivery Vectors: Methods and Protocols, 1445, 175-185. *Corresponding Author

Steven Jones, Olivia M. Merkel*: Indium-Labeling of siRNA for small animal SPECT Imaging , Methods in Molecular Biology 2016, RNA Imaging, 1372, 79-88.*Corresponding Author

Maha Elsayed, Olivia M. Merkel*: Inhaled Delivery of siRNA, "Advances and Challenges in the Delivery of Nucleic Acid Therapeutics", Vol 2, Future Science Press 2015. *Corresponding Author

Daniel P. Feldmann, Olivia M. Merkel*: The advantages of pulmonary delivery of therapeutic siRNA, Therapeutic Delivery 2015, 6 (4), 407-9, Invited Editorial *Corresponding Author

Mengyao Zheng, Thomas Kissel, Olivia M. Merkel*: Self-assembly of siRNA containing nanoparticles, Book Chapter in “RNA Nanotechnology and Therapeutics" , *Corresponding Author

Olivia M. Merkel*, Leigh Marsh, Holger Garn, Thomas Kissel: Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery, Invited Book Chapter in “Nanotechnology for Nucleic acid Delivery’ in the book series Methods in Molecular Biology, *Corresponding Author

Meredith A. Mintzer, Olivia M. Merkel, Thomas Kissel, Eric E. Simanek: Triazine dendrimers for DNA and siRNA delivery: Progress, challenges, and opportunities
Wiley-VCH 2012, Dendrimer-Based Drug Delivery Systems, Chapter 10. Triazine dendrimers for DNA and siRNA delivery: Progress, challenges, and opportunities

Olivia M. Merkel*, Meredith A. Mintzer, Eric E. Simanek, Thomas Kissel: Perfectly shaped siRNA delivery
Therapeutic Delivery 2010, 1 (6), 737-742, Invited Editorial, *Corresponding Author

Olivia M. Merkel*, Meredith A. Mintzer, Eric Simanek, Thomas Kissel: Systematically modifying triazine dendrimers for efficient RNAi
Therapeutic Delivery 2010, 1 (2), 222, News and Views, Comment on Merkel et al, Mol Pharmaceutics 2010, *Corresponding Author

Olivia M. Merkel*, Thomas Kissel: [Pulmonary application of siRNA]
Lunge, Luft und Leben 2009, 7, 14-15, Research Report honoring the Promotion to Young Researchers awarded by the German Lung Foundation, *Corresponding Author

View my collection, "My Bibliography" from NCBI