Dr. Oliver Thorn-Seshold
Chemical Biology and Pharmaceutical Chemistry
Forschungsgebiete
- Chemical Biology
- Photopharmacology for the cytoskeleton and for TRP channels
- Probing redox processes in cellular biochemistry
- Methods developments for light- & enzyme-responsive chemical tools
Kurzlebenslauf
- Since 2018: DFG Emmy Noether independent group leader, LMU Munich
- Since 2016: Independent Research, LMU Munich
- 2013-2016: Postdoctoral Research, LMU Munich (Prof. Dirk Trauner)
- 2009-2013: PhD Chemical Biology, Ecole Normale Superieure de Lyon (Prof. Jens Hasserodt)
- 2004-2009: BSc Chemistry, University of Sydney; MSc Bioorganic Chemistry, Ecole Normale Superieure de Lyon
Wichtige Publikationen
- L Zeisel, […], O Thorn-Seshold*; Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe. Chem 2022 (10.1016/j.chempr.2022.03.010)
- L Gao, […], O Thorn-Seshold*; In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M. Journal of the American Chemical Society 2022 (10.1021/jacs.2c01020)
- M Müller, […], O Thorn-Seshold*; BTDAzo - a photoswitchable TRPC5 channel activator. Angewandte Chemie 2022 (10.1002/anie.202201565)
- J Felber, […], O Thorn-Seshold*; Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically. Nature Communications 2022 (10.1038/s41467-022-29136-4)
- L Gao, […], O Thorn-Seshold*; A robust, GFP-orthogonal photoswitchable inhibitor scaffold extends optical control over the microtubule cytoskeleton.
Cell Chemical Biology 2021 (10.1016/j.chembiol.2020.11.007)
Full list of publications here. Author links: Orcid; PubMed