Research Interests

  • Chemical Biology for Drug Research
  • Foldamer design and chemical synthesis
  • Biomolecular recognition
  • Molecular shape engineering
  • X-ray crystallography

Short CV

  • 2017 W3 Professor, Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany
  • 2010 - 2017 Co-director of the Institute of Chemistry and Biology of Membranes and Nanoobjects, UMR 5248 CBMN, Bordeaux, France
  • 2008 - 2017 Co-director of the European Institute of Chemistry and Biology (IECB), Bordeaux, France
  • 1998 - 2017 CNRS Group Leader at the European Institute for Chemistry and Biology, Bordeaux, France
  • 1999 Habilitation Diploma
  • 1995 - 1998 CNRS Research Associate, Université Louis Pasteur de Strasbourg (France)
  • 1994 - 1995 Post-Doctoral Fellow, Université Louis Pasteur de Strasbourg (France)
  • 1990 - 1994 PhD Thesis, jointly at the Massachusetts Institute of Technology, Cambridge (USA), and at the Ecole Normale Supérieure, Paris (France)
  • 1990 B.Sc., chemistry, at the Ecole Normale Supérieure, Paris, France

Key publications

  • P. Mateus, N. Chandramouli, C. D. Mackereth, B. Kauffmann, Y. Ferrand, I. Huc, Allosteric recognition of homomeric and heteromeric pairs of monosaccharides by a foldamer capsule, Angew.Chem. Int. Ed. 2020, 59,5797
  • V. Corvaglia, D. Carbajo, P. Prabhakaran, K. Ziach, P.K. Mandal, V. Dos Santos, C. Legeay, R. Vogel, V. Parissi, P. Pourquier, I. Huc, Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins, Nucleic Acids Res. 2019, 47, 5511
  • J. M. Rogers, S. Kwon, S. J. Dawson, P. K. Mandal, H. Suga, I. Huc, Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids, Nat. Chem. 2018, 10, 405
  • S. De, B. Chi, T. Granier, T. Qi, V. Maurizot, I. Huc, Designing cooperatively folded abiotic uni- and multimolecular helix bundles, Nat. Chem. 2018, 10, 51
  • K. Ziach, C. Chollet, V. Parissi, P. Prabhakaran, M. Marchivie, V. Corvaglia, P. P. Bose, K. Laxmi-Reddy, F. Godde, J.-M. Schmitter, S. Chaignepain, P. Pourquier, I. Huc, Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded B-DNA, Nat. Chem. 2018, 10, 511
  • Q. Gan, X. Wang, B. Kauffmann, F. Rosu, Y. Ferrand, I. Huc, Translation of rod-like template sequences into homochiral assemblies of stacked helical oligomers, Nat. Nanotech. 2017, 12, 447
  • N. Chandramouli, Y. Ferrand, G. Lautrette, B. Kauffmann, C. D.Mackereth, M. Laguerre, D. Dubreuil, I. Huc, Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose, Nat. Chem. 2015, 7, 334
  • J. Buratto, C. Colombo, M. Stupfel, S. J. Dawson, C. Dolain, B. Langlois d'Estaintot, L. Fischer, T. Granier, M. Laguerre, B. Gallois, I. Huc, Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 Angs. resolution, Angew. Chem. Int. Ed. 2014, 53, 883
  • Q. Gan, Y. Ferrand, C. Bao, B. Kauffmann, A. Grélard, H. Jiang, I. Huc, Helix-rod host-guest complexes with shuttling rates much faster than disassembly, Science 2011, 331, 1172
  • G. Guichard, I. Huc, Synthetic foldamers, Chem. Commun. 2011, 47, 5933
  • I. Huc, Aromatic oligoamide foldamers, Eur. J. Org. Chem. 2004, 17
  • H. Jiang, J.-M. Léger, I. Huc, Aromatic delta-peptides, J. Am. Chem. Soc. 2003, 125, 3448