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Publications

2020

  • Tavares et al., tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast RNA Biology (2020)
  • Ramos J, Proven M, Halvardson J, Hagelskamp F, Kuchinskaya E, Phelan B, Bell R, Kellner S, Feuk L, Thuresson AC, Fu D (2020) Identification and rescue of a tRNA wobble inosine deficiency causing intellectual disability disorder. RNA. doi:10.1261/rna.076380.120 PMID: 32763916
  • Ignatova et al., Science advances (accepted)
  • Schack, M.A. et al. Eukaryotic life without tQCUG: the role of Elongator-dependent tRNA modifications in Dictyosteliumdiscoideum. Nucleic Acids Res (2020).
  • Borek, C., Reichle, V.F. & Kellner, S. Synthesis and Metabolic Fate of 4-Methylthiouridine in Bacterial tRNA. Chembiochem (2020).
  • Thumbs, P. et al. Synthesis of Galactosyl-Queuosine and Distribution of Hypermodified Q-Nucleosides in Mouse Tissues. Angew Chem Int Ed Engl (2020).
  • Ignatova, V.V. et al. The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs. Genes Dev 34, 715-729 (2020).
  • Hagelskamp, F., Borland, K., Ramos, J., Hendrick, A., Fu, D. and Kellner S. (2020) Broadly applicable oligonucleotide mass spectrometry for the analysis of RNA writers and erasers in vitro. Nucleic Acids Res. PMID: 32083657
  • Drino, A., Oberbauer, V., Troger, C., Janisiw, E., Anrather, D., Hartl, M., Kaiser, S., Kellner, S. and Schaefer, M. (2020) Production and Purification of Endogenously Modified tRNA-Derived Small RNAs. RNA Biology. PMID: 32138588

2019

  • Reichle, V.F., Petrov, D.P., Weber, V., Jung, K. and Kellner, S. (2019) NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli. Nat Commun, 10, 5600. PMID: 31811240
  • Meyer, B., Immer, C., Kaiser, S., Sharma, S., Yang, J., Watzinger, P., Weiss, L., Kotter, A., Helm, M., Seitz, H.M. et al. (2019) Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs. Nucleic Acids Res. PMID: 31863583
  • Barraud, P., Gato, A., Heiss, M., Catala, M., Kellner, S. and Tisne, C. (2019) Time-resolved NMR monitoring of tRNA maturation. Nat Commun, 10, 3373. PMID: 31358763
  • Ramos, J., Han, L., Li, Y., Hagelskamp, F., Kellner, S.M., Alkuraya, F.S., Phizicky, E.M. and Fu, D. (2019) Formation of tRNA wobble inosine in humans is disrupted by a millennia-old mutation causing intellectual disability. Mol Cell Biol. PMID: 31263000
  • Gkatza, N.A., Castro, C., Harvey, R.F., Heiss, M., Popis, M.C., Blanco, S., Bornelov, S., Sajini, A.A., Gleeson, J.G., Griffin, J.L. et al. (2019) Cytosine-5 RNA methylation links protein synthesis to cell metabolism. PLoS Biol, 17, e3000297. PMID: 31199786
  • Asadi-Atoi, P., Barraud, P., Tisne, C. and Kellner, S. (2019) Benefits of stable isotope labeling in RNA analysis. Biol Chem. PMID: 30893050
  • Borland, K., Diesend, J., Ito-Kureha, T., Heissmeyer, V., Hammann, C., Buck, A.H., Michalakis, S. and Kellner, S. (2019) Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis. Genes (Basel), 10. PMID: 30621251
  • Traube FR, Schiffers S, Iwan K, Kellner S, Spada F, Müller M, Carell T. (2019) Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides, Nature Protocols, PMID: 30559375

2018

  • Reichle V., Weber V. and Kellner S. (2018) NAIL-MS in E. coli determines the source and fate of methylation in tRNA , ChemBioChem, PMID: 30328661
  • Reichle VF, Kaiser S, Heiss M, Hagelskamp F, Borland K, Kellner S. (2018) Surpassing limits of static RNA modification analysis with dynamic NAIL-MS, Methods, PMID: 30395967

2017

  • Kellner S.*, Demott M.*, Chen C., Cao B. and Dedon P. (2017) Oxidation of labile phosphorothioate DNA modifications leads to lethal genomic instability, Nature Chemical Biology, PMID: 28604692
  • Dewe JM, Fuller BL, Lentini JM, Kellner SM, Fu D. (2017) TRMT1-catalyzed tRNA modifications are required for redox homeostasis to ensure proper cellular proliferation and oxidative stress survival. Mol Cell Biol. doi: 10.1128/MCB.00214-17. PubMed PMID: 28784718.
  • Heiss, M., Reichle, V. & Kellner, S. (2017). Observing the fate of tRNA and its modifications by nucleic acid isotope labeling mass spectrometry: NAIL-MS. RNA Biol. 2017 May 10:0. doi: 10.1080/15476286.2017.1325063.

2016

  • Heiss, M., & Kellner, S. (2016). Detection of nucleic acid modifications by chemical reagents. RNA Biol. 2016 Nov 30:1-9. doi: 10.1080/15476286.2016.1261788.
  • Kaiser, S., Jurkowski, T. P., Kellner, S., Schneider, D., Jeltsch, A., & Helm, M. (2016). The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA. RNA Biol, 1-11. doi:10.1080/15476286.2016.1236170
  • Thiaville, J.J., et al., Novel genomic island modifies DNA with 7-deazaguanine derivatives. Proc Natl Acad Sci U S A, 2016.

2015

  • Schmid, K., et al., Variable presence of 5-methylcytosine in commercial RNA and DNA. RNA Biol, 2015. 12(10): p. 1152-8.
  • Lin, C.J., et al., An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis. RNA, 2015. 21(12): p. 2103-18.
  • Cai, W.M., et al., A Platform for Discovery and Quantification of Modified Ribonucleosides in RNA: Application to Stress-Induced Reprogramming of tRNA Modifications. Methods Enzymol, 2015. 560: p. 29-71.
  • Bourgeois, G., et al., Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120. PLoS One, 2015. 10(7): p. e0133321.

2014

  • Spenkuch, F., et al., Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor. Nucleic Acids Res, 2014. 42(20): p. 12735-45.
  • Kellner, S., et al., Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. Nucleic Acids Res, 2014. 42(18): p. e142.
  • Kellner, S., et al., Profiling of RNA modifications by multiplexed stable isotope labelling. Chem Commun (Camb), 2014. 50(26): p. 3516-8.
  • Buchhaupt, M., et al., Partial methylation at Am100 in 18S rRNA of baker's yeast reveals ribosome heterogeneity on the level of eukaryotic rRNA modification. PLoS One, 2014. 9(2): p. e89640.
  • Blanco, S., et al., Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders. EMBO J, 2014. 33(18): p. 2020-39.

2013

  • Kellner, S., et al., Structure-function relationship of substituted bromomethylcoumarins in nucleoside specificity of RNA alkylation. PLoS One, 2013. 8(7): p. e67945.

2012

  • Tuorto, F., et al., RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Nat Struct Mol Biol, 2012. 19(9): p. 900-5.
  • Sencilo, A., et al., Related haloarchaeal pleomorphic viruses contain different genome types. Nucleic Acids Res, 2012. 40(12): p. 5523-34.

2011

  • Kellner, S., et al., A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA. Nucleic Acids Res, 2011. 39(16): p. 7348-60.

2010

  • Kellner, S., J. Burhenne, and M. Helm, Detection of RNA modifications. RNA Biol, 2010. 7(2): p. 237-47.