Mayr's Database of Reactivity Parameters

Nucleophiles

For reactivities of structurally related compounds go to: Nucleophiles

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Name Solvent Reactivity
Parameters 		Classification Reference
(title or year)
o-nitrophenolate (in DMF)
C6H4NO3 *
 DMF

N  Param.: 16.65

sN Param.: 0.70		 *** J. Org. Chem. 2019, 84, 8837-8858
10.1021/acs.joc.9b01485
o-nitrophenolate (in DMSO)
C6H4NO3 *
 DMSO

N  Param.: 15.48

sN Param.: 0.71		 *** J. Org. Chem. 2019, 84, 8837-8858
10.1021/acs.joc.9b01485
p-nitrophenolate (in DMF)
C6H4NO3 *
 DMF

N  Param.: 15.05

sN Param.: 0.80		 *** J. Org. Chem. 2019, 84, 8837-8858
10.1021/acs.joc.9b01485
p-nitrophenolate (in MeCN)
C6H4NO3 *
 MeCN

N  Param.: 15.14

sN Param.: 0.82		 *** J. Org. Chem. 2019, 84, 8837-8858
10.1021/acs.joc.9b01485
o-nitrophenolate (in MeCN)
C6H4NO3 *
 MeCN

N  Param.: 15.83

sN Param.: 0.80		 *** J. Org. Chem. 2019, 84, 8837-8858
10.1021/acs.joc.9b01485
cysteine (dianionic, in water)
C3H5NO2S *
 water

N  Param.: 23.43

sN Param.: 0.42		 *** Org. Biomol. Chem. 2007, 5, 3814-3820
10.1039/b713778h
lithium (5-methylthiophen-2-yl)(4-(trifluoromethyl)phenyl)pinacolborate
C18H21BF3LiO2S *
 MeCN

N  Param.: 6.24

sN Param.: 1.00		 ** Angew. Chem. Int. Ed. 2015, 54, 2780-2783
10.1002/anie.201410562
potassium trifluoro(furan-2-yl)borate
C4H3BF3KO *
 MeCN

N  Param.: 5.99

sN Param.: 0.79		 ** J. Am. Chem. Soc. 2013, 135, 6317-6324
10.1021/ja4017655
((3,4-dihydro-2H-pyran-6-yl)methoxy)triisopropylsilane (in MeCN)
C15H30O2Si *
 MeCN

N  Param.: 2.87

sN Param.: 0.66		 *** Angew. Chem. Int. Ed. 2026, 65, e24329
10.1002/anie.202524329
((4-methoxyphenyl)sulfonyl)(pyridin-4-yl)amide (Ph4P+) (in CH2Cl2)
C12H11N2O3S- *
 dichloromethane

N  Param.: 19.63

sN Param.: 0.65		 *** J. Am. Chem. Soc. 2025, 147, 5043-5050
10.1021/jacs.4c14825
((4-methoxyphenyl)sulfonyl)(pyridin-4-yl)amide (Ph4P+) (in MeCN)
C12H11N2O3S- *
 MeCN

N  Param.: 17.28

sN Param.: 0.65		 *** J. Am. Chem. Soc. 2025, 147, 5043-5050
10.1021/jacs.4c14825
((dimethylsilyl)methyl)trimethylsilane
C6H18Si2 *
 dichloromethane

N  Param.: 4.86

sN Param.: 0.64		 * Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
((methylsilanediyl)bis(methylene))bis(trimethylsilane)
C9H26Si3 *
 dichloromethane

N  Param.: 4.91

sN Param.: 0.64		 ** Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(1-azidovinyl)benzene
C8H7N3 *
 dichloromethane

N  Param.: 4.57

sN Param.: 0.94		 *** Chem. Commun. 2026, 62, 5041-5045
10.1039/d6cc00190d
(1H-inden-1-yl)trimethylsilane (in CH2Cl2)
C12H16Si *
 dichloromethane

N  Param.: -0.10

sN Param.: 1.05		 *** Angew. Chem. Int. Ed. 2015, 54, 12497-12500
10.1002/anie.201501385
(1H-inden-1-yl)trimethylstannane (in CH2Cl2)
C12H16Sn *
 dichloromethane

N  Param.: 6.68

sN Param.: 0.81		 *** Angew. Chem. Int. Ed. 2015, 54, 12497-12500
10.1002/anie.201501385
(1H-inden-1-yl)zinc(II) bromide*LiBr (in DMSO)
C9H7Br2LiZn *
 DMSO

N  Param.: 15.60

sN Param.: 0.51		 ** Angew. Chem. Int. Ed. 2015, 54, 12497-12500
10.1002/anie.201501385
(1H-inden-1-yl)zinc(II) chloride*LiCl (in DMSO)
C9H7Cl2LiZn *
 DMSO

N  Param.: 18.10

sN Param.: 0.46		 ** Angew. Chem. Int. Ed. 2015, 54, 12497-12500
10.1002/anie.201501385
(1S)-(-)-alpha-pinene
C10H16 *
 dichloromethane

N  Param.: 0.68

sN Param.: 1.10		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(2,2-diphenylethyl)diethyl(methyl)silane
*
 dichloromethane

N  Param.: -6.40

sN Param.: 1.10		 - Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(2,3-dimethylbut-2-enyl)triethylsilane
C12H26Si *
 dichloromethane

N  Param.: 3.15

sN Param.: 1.15		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(2-([1,1'-biphenyl]-4-yl)ethyl)trimethylstannane
*
 1,2-dichloroethane

N  Param.: -0.80

sN Param.: 1.10		 - Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(2-methylallyl)benzene
C10H12 *
 dichloromethane

N  Param.: 0.25

sN Param.: 1.00		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(2-methylallyl)dicarbonyl(cyclopentadienyl)iron(II)
*
 dichloromethane

N  Param.: 8.45

sN Param.: 0.83		 *** Helv. Chim. Acta 2005, 88, 1754-1768
10.1002/hlca.200590137
(2-methylallyl)tributylstannane
C16H34Sn *
 dichloromethane

N  Param.: 7.48

sN Param.: 0.89		 ***** J. Am. Chem. Soc. 2001, 123, 9500-9512
10.1021/ja010890y
(2-methylallyl)trichlorosilane
C4H7Cl3Si *
 dichloromethane

N  Param.: -0.57

sN Param.: 0.95		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(2-methylallyl)trimethylsilane
C7H16Si *
 dichloromethane

N  Param.: 4.41

sN Param.: 0.96		 ***** J. Am. Chem. Soc. 2001, 123, 9500-9512
10.1021/ja010890y
(2-methylallyl)triphenylgermane
C22H22Ge *
 dichloromethane

N  Param.: 4.67

sN Param.: 0.81		 ***** J. Am. Chem. Soc. 2001, 123, 9500-9512
10.1021/ja010890y
(2-methylallyl)triphenylsilane
C22H22Si *
 dichloromethane

N  Param.: 4.17

sN Param.: 0.79		 ** J. Am. Chem. Soc. 2001, 123, 9500-9512
10.1021/ja010890y
(2-methylallyl)triphenylstannane
C22H22Sn *
 dichloromethane

N  Param.: 5.13

sN Param.: 0.90		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(2-methylallyl)tris(trimethylsilyl)silane
*
 dichloromethane

N  Param.: 4.63

sN Param.: 0.87		 *** Org. Lett. 2010, 12, 5206-5209
10.1021/ol102220e
(2R,5S)-5-benzyl-3-methyl-2-(5-methylfuran-2-yl)imidazolidin-4-one
C16H18N2O2 *
 MeCN

N  Param.: 7.39

sN Param.: 1.00		 *** J. Am. Chem. Soc. 2020, 142, 1526-1547
10.1021/jacs.9b11877
(2S,5S)-5-benzyl-2-(tert-butyl)-3-methyl-1-((E)-styryl)imidazolidin-4-one
C23H28N2O *
 MeCN

N  Param.: 5.80

sN Param.: 0.87		 *** Angew. Chem. Int. Ed. 2012, 51, 5739-5742
10.1002/anie.201201240
(2S,5S)-5-benzyl-2-(tert-butyl)-3-methylimidazolidin-4-one
C15H22N2O *
 MeCN

N  Param.: 5.44

sN Param.: 1.12		 *** J. Am. Chem. Soc. 2020, 142, 1526-1547
10.1021/jacs.9b11877
(2S,5S)-5-benzyl-3-methyl-2-(5-methylfuran-2-yl)imidazolidin-4-one
C16H18N2O2 *
 MeCN

N  Param.: 8.76

sN Param.: 0.89		 *** J. Am. Chem. Soc. 2020, 142, 1526-1547
10.1021/jacs.9b11877
(3,3,4,4,5,5,6,6,7,7,7-undecafluoro)-2-(trimethylsiloxy)hept-1-ene
*
 dichloromethane

N  Param.: -3.52

sN Param.: 1.17		 *** Org. Lett. 2012, 14, 3990-3993
10.1021/ol301766w
(3,4-dihydro-2H-pyran-6-yl)trimethylsilane (in MeCN)
C8H16OSi *
 MeCN

N  Param.: 2.87

sN Param.: 0.68		 *** Angew. Chem. Int. Ed. 2026, 65, e24329
10.1002/anie.202524329
(3-chlorobenzyl)dimethylsilane
C9H13ClSi *
 dichloromethane

N  Param.: 1.30

sN Param.: 0.75		 - Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(4,4-dimethylpentyl)trimethylstannane
*
 dichloromethane/MeCN mix

N  Param.: -3.90

sN Param.: 1.10		 - Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(4,5-dihydrofuran-2-yl)trimethylsilane (in MeCN)
C7H14OSi *
 MeCN

N  Param.: 4.23

sN Param.: 0.90		 *** Angew. Chem. Int. Ed. 2026, 65, e24329
10.1002/anie.202524329
(4-(tert-butyl)phenethyl)trimethylstannane
*
 1,2-dichloroethane

N  Param.: -0.30

sN Param.: 1.10		 - Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(4-Br-C6H4)-(CO)-CH=SMe2
*
 dichloromethane

N  Param.: 11.95

sN Param.: 0.76		 *** Angew. Chem. Int. Ed. 2009, 48, 5034-5037
10.1002/anie.200900933
(4-Br-C6H4)-(CO)-CH=SMe2 (in DMSO)
*
 DMSO

N  Param.: 13.78

sN Param.: 0.72		 *** J. Am. Chem. Soc. 2010, 132, 17894-17900
10.1021/ja1084749
(4-chlorophenethyl)trimethylstannane
*
 1,2-dichloroethane

N  Param.: -1.80

sN Param.: 1.10		 - Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(4-chlorophenyl)dimethylsilane
C8H11ClSi *
 dichloromethane

N  Param.: 3.05

sN Param.: 0.73		 * Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(4-Me2N-C6H4)-(CO)-CH=SMe2 (in DMSO)
*
 DMSO

N  Param.: 15.68

sN Param.: 0.65		 *** J. Am. Chem. Soc. 2010, 132, 17894-17900
10.1021/ja1084749
(4-MeO-C6H4)-(CO)-CH=SMe2 (in DMSO)
*
 DMSO

N  Param.: 14.48

sN Param.: 0.71		 *** J. Am. Chem. Soc. 2010, 132, 17894-17900
10.1021/ja1084749
(4-methoxyphenethyl)trimethylstannane
*
 1,2-dichloroethane

N  Param.: 0.20

sN Param.: 1.10		 - Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(4-methoxyphenyl)dimethylsilane
C9H14OSi *
 dichloromethane

N  Param.: 4.23

sN Param.: 0.73		 * Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(5-methyl-furan-2-yl) MDA boronate
*
 MeCN

N  Param.: 6.38

sN Param.: 0.86		 *** Chem. Sci. 2012, 3, 878-882
10.1039/c2sc00883a
(5-methyl-furan-2-yl) MIDA boronate
*
 MeCN

N  Param.: 1.84

sN Param.: 1.26		 ** Chem. Sci. 2012, 3, 878-882
10.1039/c2sc00883a
(5-methyl-furan-2-yl) pinacol boronate
*
 MeCN

N  Param.: 2.90

sN Param.: 0.98		 *** Chem. Sci. 2012, 3, 878-882
10.1039/c2sc00883a
(5-methyl-furan-2-yl) trifluoroborate
*
 MeCN

N  Param.: 7.66

sN Param.: 1.04		 *** Chem. Sci. 2012, 3, 878-882
10.1039/c2sc00883a
(5-methyl-furan-2-yl)(1,1,1-tris(methoxy)ethane)borate
*
 MeCN

N  Param.: 12.55

sN Param.: 0.92		 *** Chem. Sci. 2012, 3, 878-882
10.1039/c2sc00883a
(allyl)dicarbonyl(cyclopentadienyl)iron(II)
*
 dichloromethane

N  Param.: 6.78

sN Param.: 0.95		 *** Helv. Chim. Acta 2005, 88, 1754-1768
10.1002/hlca.200590137
(bis(trimethylsiloxy)amino)styrene
C14H25NO2Si2 *
 dichloromethane

N  Param.: 4.80

sN Param.: 0.86		 * J. Org. Chem. 2001, 66, 3196-3200
10.1021/jo0015927
(C6H5)-(CO)-CH=SMe2 (in DMSO)
*
 DMSO

N  Param.: 13.95

sN Param.: 0.69		 *** J. Am. Chem. Soc. 2010, 132, 17894-17900
10.1021/ja1084749
(chloromethyl)dimethylsilane
C3H9ClSi *
 dichloromethane

N  Param.: 0.80

sN Param.: 0.73		 * Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
(Cp*)2Zr(Me)2 - Dimethyl-bis(pentamethylcyclopentadienyl)zirconium
C22H36Zr *
 dichloromethane

N  Param.: 5.49

sN Param.: 1.06		 *** Chem. Eur. J. 2016, 22, 11196-11200
10.1002/chem.201602452
(cyclohexen-1-yl)prolinate (in MeCN)
*
 MeCN

N  Param.: 18.86

sN Param.: 0.70		 *** Angew. Chem. Int. Ed. 2010, 49, 9526-9529
10.1002/anie.201004344
(E)-1-(1,2-diphenylvinyl)piperidine (in MeCN)
*
 MeCN

N  Param.: 9.94

sN Param.: 0.86		 *** Chem. Eur. J. 2018, 24, 5901-5910
10.1002/chem.201705962
(E)-1-(1,2-diphenylvinyl)pyrrolidine (in MeCN)
*
 MeCN

N  Param.: 11.66

sN Param.: 0.82		 *** Chem. Eur. J. 2018, 24, 5901-5910
10.1002/chem.201705962
(E)-1-(2-(4-methoxyphenyl)-1-phenylvinyl)pyrrolidine (in MeCN)
*
 MeCN

N  Param.: 11.99

sN Param.: 0.84		 *** Chem. Eur. J. 2018, 24, 5901-5910
10.1002/chem.201705962
(E)-1-(2-(4-nitrophenyl)-1-phenylvinyl)pyrrolidine (in MeCN)
*
 MeCN

N  Param.: 10.42

sN Param.: 0.82		 *** Chem. Eur. J. 2018, 24, 5901-5910
10.1002/chem.201705962
(E)-1-(N-morpholino)propene
C7H13NO *
 dichloromethane

N  Param.: 12.06

sN Param.: 0.80		 * Chem. Eur. J. 2003, 9, 2209-2218
10.1002/chem.200204666
(E)-1-styryl-2-(triphenylsilyl)pyrrolidine (in CH2Cl2)
C30H29NSi *
 dichloromethane

N  Param.: 11.77

sN Param.: 0.98		 *** J. Am. Chem. Soc. 2014, 136, 14263-14269
10.1021/ja508065e
(E)-1-styryl-2-tritylpyrrolidine (in CH2Cl2)
C31H29N *
 dichloromethane

N  Param.: 10.19

sN Param.: 1.06		 *** J. Am. Chem. Soc. 2014, 136, 14263-14269
10.1021/ja508065e
(E)-1-styrylpyrrolidine (in CH2Cl2)
C12H15N *
 dichloromethane

N  Param.: 12.26

sN Param.: 0.93		 *** J. Am. Chem. Soc. 2014, 136, 14263-14269
10.1021/ja508065e
(E)-1-styrylpyrrolidine (in MeCN)
C12H15N *
 MeCN

N  Param.: 13.87

sN Param.: 0.76		 *** Chem. Eur. J. 2018, 24, 5901-5910
10.1002/chem.201705962
(E)-13-(ethylthio)-6-styryl-6,12-diazadispiro[4.1.47.25]tridec-12-ene (in MeCN)
C21H28N2S *
 MeCN

N  Param.: 7.79

sN Param.: 0.87		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-2,2,3,5,5-pentamethyl-1-styrylimidazolidin-4-one (in MeCN)
C16H22N2O *
 MeCN

N  Param.: 7.10

sN Param.: 0.82		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-2,2,3,5,5-pentamethyl-1-styrylimidazolidine-4-thione (in MeCN)
C16H22N2S *
 MeCN

N  Param.: 6.49

sN Param.: 0.83		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-2-((1-(but-1-en-1-yl)-2,2,5,5-tetramethyl-2,5-dihydro-1H-imidazol-4-yl)thio)acetonitrile (in MeCN)
C13H21N3S *
 MeCN

N  Param.: 9.23

sN Param.: 0.74		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-2-methyl-penta-1,3-diene
C6H10 *
 dichloromethane

N  Param.: 3.09

sN Param.: 1.00		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(E)-4-(1,2-diphenylvinyl)morpholine (in MeCN)
*
 MeCN

N  Param.: 8.78

sN Param.: 0.83		 *** Chem. Eur. J. 2018, 24, 5901-5910
10.1002/chem.201705962
(E)-4-(2-phenyl-2-(pyrrolidin-1-yl)vinyl)benzonitrile (in MeCN)
*
 MeCN

N  Param.: 10.63

sN Param.: 0.84		 *** Chem. Eur. J. 2018, 24, 5901-5910
10.1002/chem.201705962
(E)-4-(benzylthio)-2,2,5,5-tetramethyl-1-styryl-2,5-dihydro-1H-imidazole (in CH2Cl2)
C22H26N2S *
 dichloromethane

N  Param.: 7.99

sN Param.: 0.98		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-4-(benzylthio)-2,2,5,5-tetramethyl-1-styryl-2,5-dihydro-1H-imidazole (in MeCN)
C22H26N2S *
 MeCN

N  Param.: 8.30

sN Param.: 0.84		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-4-(ethylthio)-2,2,5,5-tetramethyl-1-(3-phenylbut-1-en-1-yl)-2,5-dihydro-1H-imidazole (in MeCN)
C19H28N2S *
 MeCN

N  Param.: 7.92

sN Param.: 0.73		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-4-(ethylthio)-2,2,5,5-tetramethyl-1-(3-phenylprop-1-en-1-yl)-2,5-dihydro-1H-imidazole (in MeCN)
C18H26N2S *
 MeCN

N  Param.: 9.64

sN Param.: 0.70		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-4-(ethylthio)-2,2,5,5-tetramethyl-1-styryl-2,5-dihydro-1H-imidazole (in CH2Cl2)
C17H24N2S *
 dichloromethane

N  Param.: 8.13

sN Param.: 0.97		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-4-(ethylthio)-2,2,5,5-tetramethyl-1-styryl-2,5-dihydro-1H-imidazole (in MeCN)
C17H24N2S *
 MeCN

N  Param.: 8.12

sN Param.: 0.88		 *** Chem. Eur. J. 2024, 30, e202302764
10.1002/chem.202302764
(E)-4-styrylmorpholine
*
 MeCN

N  Param.: 11.66

sN Param.: 0.83		 *** Chem. Eur. J. 2018, 24, 5901-5910
10.1002/chem.201705962
(E)-beta-(N-morpholino)styrene
C12H15NO *
 dichloromethane

N  Param.: 10.76

sN Param.: 0.87		 *** Chem. Eur. J. 2003, 9, 2209-2218
10.1002/chem.200204666
(E)-beta-(N-piperidino)styrene (in MeCN)
*
 MeCN

N  Param.: 13.84

sN Param.: 0.73		 *** Chem. Eur. J. 2018, 24, 5901-5910
10.1002/chem.201705962
(E)-but-2-ene
C4H8 *
 dichloromethane

N  Param.: -2.45

sN Param.: 1.10		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(E)-but-2-enyltrimethylsilane
C7H16Si *
 dichloromethane

N  Param.: 1.94

sN Param.: 1.10		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(E)-penta-1,3-diene
C5H8 *
 dichloromethane

N  Param.: 1.49

sN Param.: 1.00		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(E)-propenylbenzene
C9H10 *
 dichloromethane

N  Param.: -0.49

sN Param.: 1.18		 ***** J. Am. Chem. Soc. 2012, 134, 13902-13911
10.1021/ja306522b
(E,E)-2,5-heptadiene
C7H12 *
 dichloromethane

N  Param.: -0.74

sN Param.: 0.99		 *** J. Am. Chem. Soc. 2002, 124, 4076-4083
10.1021/ja0121538
(E,E)-hexa-2,4-diene
C6H10 *
 dichloromethane

N  Param.: 1.17

sN Param.: 1.10		 * Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c
(EtO)2P(O)CH(-)CN (in DMSO)
*
 DMSO

N  Param.: 18.57

sN Param.: 0.66		 *** J. Am. Chem. Soc. 2009, 131, 704-714
10.1021/ja8056216
(EtO)2P(O)CH(-)CO2Et (in DMSO)
*
 DMSO

N  Param.: 19.23

sN Param.: 0.65		 *** J. Am. Chem. Soc. 2009, 131, 704-714
10.1021/ja8056216
(F)2-HBTM (in CH2Cl2)
C16H12F2N2S *
 dichloromethane

N  Param.: 10.83

sN Param.: 0.80		 *** ARKIVOC 2024, (4), 202312093
10.24820/ark.5550190[...]
(p-bromophenyl)diazomethane
*
 dichloromethane

N  Param.: 8.87

sN Param.: 0.82		 *** J. Am. Chem. Soc. 2018, 140, 16758-16772
10.1021/jacs.8b09995
(p-cyanophenyl)diazomethane
*
 dichloromethane

N  Param.: 7.66

sN Param.: 0.80		 *** J. Am. Chem. Soc. 2018, 140, 16758-16772
10.1021/jacs.8b09995
(p-nitrophenyl)diazomethane
*
 dichloromethane

N  Param.: 7.17

sN Param.: 0.83		 *** J. Am. Chem. Soc. 2018, 140, 16758-16772
10.1021/jacs.8b09995
(R)-2-(tert-butyl)-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine
*
 dichloromethane

N  Param.: 12.95

sN Param.: 0.58		 *** J. Org. Chem. 2011, 76, 5104-5112
10.1021/jo200803x
(R)-2-benzhydryl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine
*
 dichloromethane

N  Param.: 15.30

sN Param.: 0.55		 *** J. Org. Chem. 2011, 76, 5104-5112
10.1021/jo200803x
(R)-2-isopropyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine
*
 dichloromethane

N  Param.: 16.50

sN Param.: 0.48		 *** J. Org. Chem. 2011, 76, 5104-5112
10.1021/jo200803x