Publications Prof DI Dr Ernst Wagner (since 2000)

• Grau M, Wagner E (2024) Strategies and Mechanisms for Endosomal Escape of Therapeutic Nucleic Acids, Curr Op Chem Biol 2024 Aug:81:102506
• Steffens RC, Thalmayr S, Weidinger E, Seidl J, Folda P, Höhn M, Wagner E. (2024) Modulating efficacy and cytotoxicity of lipoamino fatty acid nucleic acid carriers using disulfide or hydrophobic spacers, Nanoscale 2024 Jul 25;16(29):13988-14005
• Yazdi M, Pöhmerer J, Hasanzadeh Kafshgari M, Seidl J, Grau M, Höhn M, Vetter V, Hoch CC, Wollenberg B, Multhoff G, Bashiri Dezfouli A, Wagner E (2024) In Vivo Endothelial Cell Gene Silencing by siRNA-LNPs Tuned with Lipoamino Bundle Chemical and Ligand Targeting. Small 2024 Jun 25:e2400643
• Zhang F, Burghardt T, Höhn M, Wagner E (2024) Dual Effect by Chemical Electron Transfer Enhanced siRNA Lipid Nanoparticles: Reactive Oxygen Species-Triggered Tumor Cell Killing Aggravated by Nrf2 Gene Silencing. Pharmaceutics 2024 Jun 7;16(6):779
• Germer J, Lessl AL, Pöhmerer J, Grau M, Weidinger E, Höhn M, Yazdi M, Cappelluti MA, Lombardo A, Lächelt U, Wagner E. (2024) Lipo-Xenopeptide Polyplexes for CRISPR/Cas9 Based Gene Editing at Ultra-Low Dose. J. Control. Release 2024 Jun:370:239-255
• Zou ZF, Yang L, Nie HJ, Gao J, Lei SM, Lai Y, Zhang F, Wagner E, Yu HJ, Chen XH, Xu ZA. (2024) Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy, Acta Pharmacol Sin. 2024 Aug;45(8):1740-1751
• Steffens RC, Folda P, Fendler NL, Höhn M, Bücher-Schossau K, Kempter S, Snyder NL, Hartmann L, Wagner E, Berger S. (2024) GalNAc- or Mannose-PEG-Functionalized Polyplexes Enable Effective Lectin-Mediated DNA Delivery, Bioconjug Chem. 2024 Mar 20;35(3):351-370
• Yazdi M, Hasanzadeh Kafshgari M, Khademi Moghadam F, Zarezade V, Oellinger R, Khosravi M, Haas S, Hoch CC, Pockley AG, Wagner E, Wollenberg B, Multhoff G, Bashiri Dezfouli A. (2024) Crosstalk between NK Cell Receptors and Tumor Membrane Hsp70-Derived Peptide: A Combined Computational and Experimental Study. Adv. Sci. 2024 Apr;11(14):e2305998
• Berger S, Lächelt U, Wagner E. (2024) Dynamic carriers for therapeutic RNA delivery. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307799120
• Lyu M, Yazdi M, Lin Y, Höhn M, Lächelt U, Wagner E. (2024) Receptor-Targeted Dual pH-Triggered Intracellular Protein Transfer. ACS Biomater Sci Eng. 2024 Jan 8;10(1):99-114
• Albuquerque LJC, de Oliveira FA, Christoffolete MA, Nascimento-Sales M, Berger S, Wagner E, Lächelt U, Giacomelli FC. (2024) Nucleic acid delivery to retinal cells using lipopeptides as a potential tool towards ocular gene therapies, J. Colloid Interface Sci. 2024 Feb:655:346-356
• Haase F, Pöhmerer J, Yazdi M, Grau M, Zeyn Y, Wilk U, Burghardt T, Höhn M, Hieber C, Bros M, Wagner E, Berger S. (2024) Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity. Eur. J. Pharm. Biopharm. 2024:194, 95–109
• Zhou F, Huang L, Li S, Yang W, Chen F, Cai Z, Liu X, Xu W, Lehto VP, Lächelt U, Huang R, Shi Y, Lammers T, Tao W, Xu Z, Wagner E, Xu ZP, Yu H. (2023) From structural design to delivery: mRNA therapeutics for cancer immunotherapy, Exploration (Beijing). 2023 Nov 17;4(2):20210146
• Zeyn, Y., Hobernik, D., Wilk, U., Pöhmerer, J., Hieber, C, Medina-Montano, C., Röhrig, N., Mohr, C.F., Thoma-Kress, A.K., Wagner, E., Bros, M., Berger, S. (2023) Transcriptional Targeting of Dendritic Cells Using an Optimized Human Fascin1 Gene Promoter, Int. J. Mol. Sci. 2023 Nov 29;24(23):16938
• Lessl AL, Pöhmerer J, Lin Y, Wilk U, Höhn M, Hörterer E, Wagner E, Lächelt U. (2023) mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates, Bioconjug. Chem. 2023 Dec 20;34(12):2263-2274
• Zhang, F., Benli-Hoppe, T., Guo, W., Seidl, J., Wang, Y., Huang, R., Wagner, E. (2023) Receptor-Targeted Carbon Nanodot Delivery through Polymer Caging and Click Chemistry-Supported LRP1 Ligand Attachment, Polymers (Basel) 2023 Oct 10;15(20):4039
• Öztürk Ö, Lessl AL, Höhn M, Wuttke S, Nielsen PE, Wagner E, Lächelt U. (2023) Peptide nucleic acid-zirconium coordination nanoparticles, Sci Rep. 2023 Aug 30;13(1):14222
• Kitzberger C, Shehzad K, Morath V, Spellerberg R, Ranke J, Steiger K, Kälin RE, Multhoff G, Eiber M, Schilling F, Glass R, Weber WA, Wagner E, Nelson PJ, Spitzweg C. (2023) Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice, Mol Ther Oncolytics 2023 Aug 15:30:238-253
• Hall A, Bartek J, Wagner E, Lächelt U, Moghimi SM. (2023) High-resolution bioenergetics correlates the length of continuous protonatable diaminoethane motif of four-armed oligo(ethanamino)amide transfectants to cytotoxicity, J Control Release 2023 Sep:361:115-129
• Thalmayr S, Grau M, Peng L, Pöhmerer J, Wilk U, Folda P, Yazdi M, Weidinger E, Burghardt T, Höhn M, Wagner E, Berger S. (2023) Molecular Chameleon Carriers for Nucleic Acid Delivery: The Sweet Spot between Lipoplexes and Polyplexes, Adv. Mater. 2023 Jun;35(25):e2211105
• Shen, F., Lin, Y., Höhn, M., Luo, X., Döblinger, M., Wagner, E., Lächelt, U. (2023) Iron-gallic acid peptide nanoparticles as versatile platform for cellular delivery with synergistic ROS enhancement effect, Pharmaceutics 2023 Jun 21;15(7):1789
• LinY., Luo, X., Burghardt, T., Dörrer, S., Höhn, M., Wagner, E., Lächelt, U. (2023) Chemical evolution of amphiphilic xenopeptides for potentiated Cas9 ribonucleoprotein delivery, J Am Chem Soc. 2023 Jul 19;145(28):15171-15179
• Zhang F, Lin Y, Höhn M, Wagner E. (2023) Chemical-electron-transfer-based lipopolyplexes for enhanced siRNA delivery, Cell Reports Physical Science 4, 101444, Jun 21, 2023
• Steffens RC, Wagner E. (2023) Directing the way - Receptor and chemical targeting strategies for nucleic acid delivery, Pharm Res. 2023 Jan;40(1):47-76
• Lin Y, Wilk U, Pöhmerer J, Hörterer E, Höhn M, Luo X, Mai H, Wagner E, Lächelt U. (2023) Folate receptor-mediated delivery of Cas9 RNP for enhanced immune checkpoint disruption in cancer cells, Small. 2023 Jan;19(2):e2205318
• Kitzberger C, Spellerberg R, Han Y, Schmohl KA_, Stauss C, Zach C, Kälin RE, Multhoff G, Eiber M, Schilling F, Glass R, Weber WA, Wagner E, Nelson PJ, Spitzweg C (2023) Mesenchymal Stem Cell-mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice, Clin Cancer Res. 2023 Mar 1;29(5):930-942
• Lyu M, Yazdi M, Lin Y, Höhn M, Lächelt U, Wagner E. (2022) Receptor-Targeted Dual pH-Triggered Intracellular Protein Transfer, ACS Biomater Sci Eng. 2022 Jul 8. doi: 10.1021/acsbiomaterials.2c00476. Online ahead of print
• Mirzazadeh Dizaji N, Lin Y, Bein T, Wagner E, Wuttke S, Lächelt U, Engelke H (2022) Biomimetic mineralization of iron-fumarate nanoparticles for protective encapsulation and intracellular delivery of proteins, Chem Mater. 2022 Oct 11;34(19):8684-8693
• M Lee, PJ Rice-Boucher, L Thrasher Collins, E Wagner, L Aulisa, J Hughes, DT Curiel (2022) A Novel Piggyback Strategy for mRNA Delivery Exploiting Adenovirus Entry Biology, Viruses. 2022 Sep 30;14(10):2169
• Spellerberg R, Benli-Hoppe T, Kitzberger C, Hageneier M, Schwenk N, Öztürk Ö, Steiger K, Multhoff G, Eiber M, Schilling F, Weber WA, Kälin RE, Glass R, Nelson PJ, Wagner E, Spitzweg C. (2022) Dual EGFR- and TfR-targeted gene transfer for sodium iodide symporter gene therapy of glioblastoma, Mol Ther Oncolytics. 2022 Nov 3;27:272-287
• Köhler B, Dubovik S, Hörterer E, Wilk U, Stöckl JB, Tekarslan-Sahin H, Ljepoja B, Paulitschke P, Fröhlich T, Wagner E, Roidl A (2022) Combating drug resistance by exploiting miRNA-200c-controlled phase II detoxification, Cancers (Basel). 2022 Nov 11;14(22):5554
• Bashiri Dezfouli A, Yazdi M, Benmebarek M-R, Schwab M, Michaelides S, Miccichè A, Geerts D, Stangl S, Klapproth S, Wagner E, Kobold S, Multhoff G (2022) CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells, Front Immunol. 2022 Jun 1;13:883694
• Kitzberger, C., Spellerberg, R., Morath, V., Schwenk, N., Schmohl, K.A., Schug, C., Urnauer, S., Tutter, M., Eiber, M., Schilling, F., Weber, W.A., Ziegler, S., Bartenstein, P., Wagner, E., Nelson, P.J., Spitzweg, C. (2022) The sodium iodide symporter (NIS) as theranostic gene: its emerging role in new imaging modalities and non-viral gene therapy, EJNMMI Res. 2022 May 3;12(1):25
• Vetter, V.C., Wagner, E. (2022) Targeting nucleic acid-based therapeutics to tumors: Challenges and strategies for polyplexes, J Control Release 2022 Apr 21;346:110-135
• Berger, S., Berger, M., Bantz, C., Maskos, M., Wagner, E. (2022) Performance of nanoparticles for biomedical applications: the in vitro / in vivo discrepancy, Biophysics Reviews 3, 011303
• Lin, Y., Wagner, E., Lächelt, U. (2022) Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP, Biomaterials Science 2022 Mar 2;10(5):1166-1192
• Capelôa L, Yazdi M, Zhang H, Chen X, Nie Y, Wagner E, Lächelt U, Barz M. (2022) Cross-linkable Polyion Complex Micelles from Polypept(o)ide-based ABC-triblock Copolymers for siRNA Delivery, Macromol Rapid Commun. 2022 Jun;43(12):e2100698
• Benli-Hoppe T, Göl Öztürk Ş, Öztürk Ö, Berger S, Wagner E, Yazdi M. (2022) Transferrin Receptor Targeted Polyplexes Completely Comprised of Sequence-Defined Components, Macromol Rapid Commun. 2022 Jun;43(12):e2100602
• Dezfouli, A.B.; Yazdi, M.; Pockley, A.G.; Khosravi, M.; Kobold, S.; Wagner, E.; Multhoff, G. (2021) NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development, Cells 2021 Dec 1;10(12):3390
• Spellerberg R, Benli-Hoppe T, Kitzberger C, Berger S, Schmohl KA, Schwenk N, Yen HY, Zach C, Schilling F, Weber WA, Kälin RE, Glass R, Nelson PJ, Wagner E, Spitzweg C. (2021) Selective sodium iodide symporter (NIS) gene therapy of glioblastoma mediated by EGFR-targeted lipopolyplexes, Mol Ther Oncolytics 2021 Oct 30;23:432-446
• Büning H, Fehse B, Ivics Z, Kochanek S, Koehl U, Kupatt C, Mussolino C, Nettelbeck DM, Schambach A, Uckert W, Wagner E, Cathomen T. (2021) Gene Therapy "Made in Germany": A Historical Perspective, Analysis of the Status Quo, and Recommendations for Action by the German Society for Gene Therapy, Hum Gene Ther. 2021 Oct;32(19-20):987-996
• Krhač Levačić A, Berger S, Müller J, Wegner A, Lächelt U, Dohmen C, Rudolph C, Wagner E. (2021) Dynamic mRNA polyplexes benefit from bioreducible cleavage sites for in vitro and in vivo transfer, J Control Release 2021 Nov 10;339:27-40
• Spitzweg C, Nelson PJ, Wagner E, Bartenstein P, Weber WA, Schwaiger M, Morris JC. (2021) The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment. Endocr Relat Cancer. 2021 Sep 3;28(10):T193-T213
• Kamenac A, Schilberth FL, Wagner E, Wixforth A, Lächelt U, Westerhausen C. (2021) Transient Permeabilization of Living Cells: Combining Shear Flow and Acoustofluidic Trapping for the Facilitated Uptake of Molecules. Processes. 2021; 9(6):913
• Berger, S., Krhač Levačić, A., Hörterer, E., Wilk, U., Benli-Hoppe, T., Wang, Y., Öztürk, Ö., Luo, J., Wagner, E. (2021) Optimizing pDNA lipo-polyplexes: A balancing act between stability and cargo release. Biomacromolecules. 2021 Mar 8;22(3):1282-1296
• Loy, D.M., Krzysztoń, R., Lächelt, U, Rädler, J.O., Wagner, E. (2021) Controlling Nanoparticle Formulation: A Low-Budget Prototype for the Automation of a Microfluidic Platform. Processes 2021, 9(1), 129
• von Schirnding, C., Giopanou, I., Hermawan, A., Wehl, L., Ntaliarda, G., Illes, B., Datz, S., Geisslinger, F., Bartel, K., Sommer, A.K., Lianou, M., Weiß, V., Feckl, J., Vollmar, A.V., Bräuchle, C., Stathopoulos, G. T., Wagner, E., Roidl, A., Bein, T., Engelke, H. (2021) Synergistic Combination of Calcium and Citrate in Mesoporous Nanoparticles Targets Pleural Tumors. Chem 7 (2), 480-494
• Luo, J., Schmaus, J., Cui, M., Hörterer, E., Wilk, U., Höhn, M., Däther, M., Berger, S., Benli-Hoppe, T., Peng, L., Wagner, E. (2021) Hyaluronate siRNA nanoparticles with positive charge display rapid attachment to tumor endothelium and penetration into tumors, J Control Release 2021 Jan 10;329:919-933
• Freitag, F., Wagner, E. (2021) Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach, Adv Drug Deliv Rev. 2021 Jan;168:30-54
• Tutter, M., Schug, C., Schmohl, K.A., Urnauer, S., Kitzberger, C., Schwenk, N., Petrini, M., Zach, C., Ziegler, S., Bartenstein, P., Weber, W., Multhoff, G., Wagner, E., Lindner, L.H., Nelson, P.J., Spitzweg, C. (2021) Regional Hyperthermia Enhances Mesenchymal Stem Cell Recruitment to Tumor Stroma: Implications for Mesenchymal Stem Cell-Based Tumor Therapy, Mol Ther. 2021 Feb 3;29(2):788-803
• Ritt, N., Berger, S., Wagner, E., Zentel, R. (2020) Versatile, Multifunctional Block-Copolymers for the Self-Assembly of Well-Defined, Non-Toxic pDNA Polyplexes, ACS Appl. Polym. Mater. 2020, 2, 12, 5469–5481
• Zhang P, Zhang Y, Ding X, Shen W, Li M, Wagner E, Xiao C, Chen X. (2020) A Multistage Cooperative Nanoplatform Enables Intracellular Co-Delivery of Proteins and Chemotherapeutics for Cancer Therapy, Adv Mater. 2020 Nov;32(46):e2000013
• Hager, S., Fittler, F.J., Wagner, E., Bros, M. (2020) Nucleic Acid-Based Approaches for Tumor Therapy, Cells. 2020 Sep 9;9(9):2061
• Wang, Y., Wagner, E. (2020) Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization, Pharmaceutics. 2020 Sep 18;12(9):888
• Haddick, L., Zhang, W., Reinhard, S., Möller, K., Engelke, H., Wagner, E., Bein, T. (2020) Particle-Size-Dependent Delivery of Antitumoral miRNA Using Targeted Mesoporous Silica Nanoparticles, Pharmaceutics . 2020 Jun 2;12(6):505
• Zhang X, Feng L, Dong Z, Xin X, Yang Z, Deng D, Wagner E, Liu Z, Liu X. (2020) Protein-drug conjugate programmed by pH-reversible linker for tumor hypoxia relief and enhanced cancer combination therapy, Int J Pharm 2020 May 30;582:119321
• Hirschle, P., Hirschle, C., Böll, K., Döblinger, M., Höhn, M., Tuffnell, J.M., Ashling, C.W., Keen, D.A., Bennett, T.D., Rädler, J.O., Wagner, E., Peller, M., Lächelt, U., Wuttke, S. (2020) Tuning the Morphological Appearance of Iron(III) Fumarate: Impact on Material Characteristics and Biocompatibility, Chem. Mater. 2020, 32, 6, 2253-2263
• Tutter M, Schug C, Schmohl KA, Urnauer S, Schwenk N, Petrini M, Lokerse WJM, Zach C, Ziegler S, Bartenstein P, Weber WA, Wagner E, Lindner LH, Nelson PJ, Spitzweg C (2020) Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (NIS) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells, Theranostics. 2020 Mar 15;10(10):4490-4506
• Luo J, Wagner E, Wang Y (2020) Artificial peptides for antitumoral siRNA delivery, J Mater Chem B. 2020 Mar 11;8(10):2020-2031
• Kuhn J, Lin Y, Krhac Levacic A, Al Danaf N, Peng L, Höhn M, Lamb DC, Wagner E, Lächelt U (2020) Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides, Bioconjug Chem. 2020 Mar 18;31(3):729-742
• Wang, Y. Luo, J., Truebenbach, I., Reinhard, S., Klein, P., Hoehn, M., Kern, S., Morys, S., Loy, D., Wagner, E., Zhang, W. (2020) Double Click-Functionalized siRNA Polyplexes for Gene Silencing in Epidermal Growth Factor Receptor-Positive Tumor Cells, ACS Biomater. Sci. Eng. 2020, 6, 2, 1074-1089
• Ljepoja B, Schreiber C, Gegenfurtner FA, García-Roman J, Köhler B, Zahler S, Rädler JO, Wagner E, Roidl A (2019) Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A, PLoS One. 2019 Nov 20;14(11):e0224314
• Sommer, A.K., Falcenberg, M., Ljepoja, B., Fröhlich, T., Arnold, G.J., Wagner, E., Roidl, A. (2019) Downregulation of GRK5 hampers the migration of breast cancer cells, Sci Rep. 2019 Oct 29;9(1):15548
• Steinborn, B., Hirschle, P., Höhn, M., Bauer, T., Barz, M., Wuttke, S., Wagner, E., Lächelt, U. (2019) Core-Shell Functionalized Zirconium-Pemetrexed Coordination Nanoparticles as Carriers with a High Drug Content, Adv Therapeutics 2019, 1900120
• Kuhn, J., Klein, P. M., Al Danaf, N., Nordin, J. Z., Reinhard, S., Loy, D. M., Höhn, M., El Andaloussi, S., Lamb, D. C., Wagner, E., Aoki, Y., Lehto, T., Lächelt, U. (2019) Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles, Adv. Funct. Mater. 2019, 1906432
• Peng, L., Wagner, E. (2019) Polymeric Carriers for Nucleic Acid Delivery: Current Designs and Future Directions, Biomacromolecules. 2019 Oct 14;20(10):3613-3626
• Loy, D.M., Klein, P.M., Krzysztoń, R., Lächelt, U., Rädler, J.O., Wagner, E. (2019) A microfluidic approach for sequential assembly of siRNA polyplexes with a defined structure – activity relationship, PeerJ Materials Science 2019, 1-37. DOI: 10.7717/peerj-matsci.1
• Truebenbach, I., Zhang, W., Wang, Y., Kern, S., Höhn, M., Reinhard, S., Gorges, J., Kazmaier, U., Wagner, E. (2019) Co-delivery of pretubulysin and siEG5 to EGFR overexpressing carcinoma cells, Int J Pharm. 2019 Oct 5;569:118570
• Schug, C., Kitzberger, C., Sievert, W., Spellerberg, R., Tutter, M., Schmohl, K.A., Eberlein, B., Biedermann, T., Steiger, K., Zach, C., Schwaiger, M., Multhoff, G., Wagner, E., Nelson, P.J., and Spitzweg, C. (2019) Radiation-induced amplification of TGFB1-induced mesenchymal stem cell-mediated NIS gene 131, Clin Cancer Res. 2019 Oct 1;25(19):5997-6008
• Truebenbach, I., Kern, S., Loy, D.M., Hoehn, M., Gorges, J., Kazmaier, U., Wagner E. (2019) Combination chemotherapy of L1210 tumors in mice with pretubulysin and methotrexate nanoparticles, Mol Pharm. 2019 Jun 3;16(6):2405-2417
• Luo, J., Höhn, M., Reinhard, S., Loy, D.M., Klein, P.M., Wagner, E. (2019) IL4-receptor-targeted dual antitumoral apoptotic peptide - siRNA conjugate lipoplexes, Adv. Funct. Materials 29 (25), 1900697
• Schnitzler, L.G., Junger, S., Loy, D.M., Wagner, E., Wixforth, A., Hörner, A., Lächelt, U., Westerhausen, C. (2019) Size tunable nanoparticle formation employing droplet fusion by acoustic streaming applied to polyplexes, J Physics D: Applied Physics, 52, 244002
• Pfitzer, L., Moser, C., Gegenfurtner, F., Arner, A., Foerster, F., Atzberger, C., Zisis, T., Kubisch-Dohmen, R., Busse, J., Smith, R., Timinszky, G., Kalinina, O., Müller, R., Wagner, E., Vollmar, A.M., Zahler, S. (2019) Targeting actin inhibits repair of doxorubicin induced DNA damage: a novel therapeutic approach for combination therapy, Cell Death Dis. 2019 Apr 3;10(4):302
• Zimpel, A., Al Danaf, N., Steinborn, B., Kuhn, J., Höhn, M., Bauer, T., Hirschle, P., Schrimpf, W., Engelke, H., Wagner, E., Barz, M., Lamb, D.C., Lächelt, U., Wuttke, S. (2019) Coordinative binding of polymers to metal-organic framework nanoparticles for control of interactions at the biointerface, ACS Nano. 2019 Apr 23;13(4):3884-3895
• Klein, P.M., Wagner, E. (2019) Click-shielded and targeted lipopolyplexes, Methods Mol Biol. 2019;2036:141-164
• Lee, D.-J., Wagner, E. (2019) Combinatorial siRNA polyplexes for receptor targeting, Methods Mol Biol. 2019;1974:83-98
• Rödl, W., Taschauer, A., Schaffert, D., Wagner, E., Ogris, M. (2019) Synthesis of polyethylenimine based nanocarriers for systemic tumor targeting of nucleic acids, Methods Mol Biol. 2019;1943:83-99
• Reinhard, S., Wagner, E. (2019) Sequence-Defined Cationic Lipo-Oligomers Containing Unsaturated Fatty Acids for Transfection, Methods Mol Biol. 2019;1943:1-25
• Urnauer, S., Schmohl, K. A., Tutter, M., Schug, C., Schwenk, N., Morys, S., Ziegler, S., Bartenstein, P., Clevert, D. A., Wagner, E., Spitzweg, C. (2019) Dual-targeted NIS polyplexes – a theranostic strategy towards tumors with heterogenous receptor expression, Gene Ther. 2019 Apr;26(3-4):93-108
• Mastrella G, Hou M, Li M, Stoecklein VM, Zdouc N, Volmar MNM, Miletic H, Reinhard S, Herold-Mende CC, Kleber S, Eisenhut K, Gargiulo G, Synowitz M, Vescovi AL, Harter PN, Penninger JM, Wagner E, Mittelbronn M, Bjerkvig R, Hambardzumyan D, Schüller U, Tonn JC, Radke J, Glass R, Kälin RE(2019) Targeting APLN/APLNR improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGFA/VEGFR2-blockade in glioblastoma, Cancer Res. 2019 May 1;79(9):2298-2313
• Kern, S., Truebenbach, I., Höhn, M., Gorges, J., Kazmaier, U., Zahler, S., Vollmar, A. M., Wagner, E. (2019) Combined antitumoral effects of pretubulysin and methotrexate, Pharmacol Res Perspect. 2019 Jan 22;7(1):e00460
• Schug, C., Urnauer, S., Jäckel, C., Schmohl, K.A., Tutter, M., Steiger, K., Schwenk, N., Schwaiger, M., Wagner, E., Nelson, P.J., Spitzweg, C. (2019) TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer, Endocr Relat Cancer. 2019 Jan 1;26(1):89-101
• Ljepoja, B., García-Roman, J., Sommer, A.K., Wagner, E., Roidl, A. (2018) MiRNA-27a sensitizes breast cancer cells to treatment with Selective Estrogen Receptor Modulators, Breast. 2019 Feb;43:31-38
• Reinhard, S., Wang, Y., Dengler, S., Wagner, E. (2018) Precise enzymatic cleavage sites for improved bioactivity of siRNA lipo-polyplexes, Bioconjug Chem. 2018 Nov 21;29(11):3649-3657
• Hager, S., Wagner, E. (2018) Bioresponsive polyplexes - chemically programmed for nucleic acid delivery, Expert Opin Drug Deliv. 2018 Nov;15(11):1067-1083
• Klein, P.M., Klinker, K., Zhang, W., Kern, S., Kessel, E., Wagner, E., Barz, M. (2018) Efficient Shielding of Polyplexes using Heterotelechelic Polysarcosines, Polymers 2018, 10(6), 689
• Sommer, A.K., Hermawan, A., Ljepoja, B., Fröhlich, T., Arnold, G.J., Wagner, E., Roidl, A. (2018) A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF‑7 breast cancer cells, Int J Mol Med. 2018 Oct;42(4):1987-1997
• Schug C, Sievert W, Urnauer S, Müller AM, Schmohl KA, Wechselberger A, Schwenk N, Lauber K, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C(2018) External Beam Radiation Therapy Enhances Mesenchymal Stem Cell-Mediated Sodium-Iodide Symporter Gene Delivery, Hum Gene Ther. 2018 Nov;29(11):1287-1300
• Ljepoja B, García-Roman J, Sommer AK, Fröhlich T, Arnold GJ, Wagner E, Roidl A (2018) A proteomic analysis of an in vitro knock-out of miR-200c, Sci Rep. 2018 May 2;8(1):6927
• Klein, P.M., Kern, S., Lee, D.J., Schmaus, J., Höhn, M., Gorges, J., Kazmaier, U., Wagner, E. (2018) Folate receptor-directed orthogonal click-functionalization of siRNA lipopolyplexes for tumor cell killing in vivo, Biomaterials. 2018 Sep;178:630-642
• Deglmann, C.J., Błażków-Schmalzbauer, K., Moorkamp, S., Wallmichrath, J., Giunta, R.E., Rogach, A.L., Wagner, E., Baumeister, R.G., Ogris, M. (2018) In vivo tracking of adipose tissue grafts with cadmium-telluride quantum dots, Arch Plast Surg. 2018 Mar;45(2):111-117
• Steinborn B., Truebenbach I., Morys S., Lächelt U., Wagner E., Zhang W. (2018) Epidermal growth factor receptor targeted methotrexate and small interfering RNA co-delivery, J Gene Med. 2018 Jul;20(7-8):e3041
• Qian, M., Du, Y., Wang, S., Li, C., Jiang, H., Shi, W., Chen, J., Wang, Y., Wagner, E., Huang, R. (2018) Highly Crystalline Multicolor Carbon Nanodots for Dual-Modal Imaging-Guided Photothermal Therapy of Glioma, ACS Appl Mater Interfaces. 2018 Jan 31;10(4):4031-4040
• Urbiola, K., Blanco-Fernández, L., Ogris, M., Rödl, W., Wagner, E., Tros de Ilarduya, C. (2018) Novel PAMAM-PEG-peptide conjugates for siRNA delivery targeted to the transferrin and epidermal growth factor receptors, J Pers Med. 2018 Jan 9;8(1)
• Hirschberger, K., Jarzebinska, A., Kessel, E., Kretzschmann, V., Aneja, M.K., Dohmen, C., Herrmann-Janson, A., Wagner, E., Plank, C., Rudolph, C. (2017) Exploring cytotoxic mRNAs as a novel class of anti-cancer biotherapeutics, Mol Ther Methods Clin Dev. 2017 Dec 24;8:141-151
• Schmohl, K.A., Dolp, P., Schug, C., Knoop, K., Klutz, K., Schwenk, N., Bartenstein, P., Nelson, P.J., Ogris, M., Wagner, E., Spitzweg, C. (2017) Reintroducing the sodium iodide symporter (NIS) to anaplastic thyroid carcinoma, Thyroid. 2017 Dec;27(12):1534-1543
• Krhac Levacic, A., Morys, S., Wagner, E. (2017) Solid-phase Supported Design of Carriers for Therapeutic Nucleic Acid Delivery, Biosci Rep. 2017 Oct 31;37(5). pii: BSR20160617
• Urnauer S., Müller A. M., Schug, C., Schmohl, K.A., Tutter, M., Schwenk, N., Rödl, W., Morys, S., Ingrisch, M., Bertram, J., Bartenstein, P., Clevert, D.A., Wagner, E., Spitzweg, C. (2017) EGFR-targeted nonviral NIS gene transfer for bioimaging and therapy of disseminated colon cancer metastases, Oncotarget. 2017 Sep 16;8(54):92195-92208
• Wang, S., Reinhard, S., Li, C., Qian, M., Jiang, H., Du, Y., Lächelt, U., Lu, W., Wagner, E., Huang, R. (2017) Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma, Mol Ther. 2017 Jul 5;25(7):1556-1566
• Krhac Levacic, A., Morys, S., Kempter, S., Lächelt, U., Wagner, E. (2017) Minicircle Versus Plasmid DNA Delivery by Receptor-Targeted Polyplexes, Hum Gene Ther. 2017 Oct;28(10):862-874
• Lee, D.J., Kessel, E., Lehto, T., Liu, X., Yoshinaga, N., Padari, K., Chen, Y.-C., Kempter, S., Uchida, S., Rädler, J.O., Pooga, M., Sheu, M.-T., Kataoka, K., Wagner, E. (2017) Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia, Bioconjug Chem. 2017 Sep 20;28(9):2393-2409
• Morys, S., Urnauer, S., Spitzweg, C., Wagner, E. (2017) EGFR Targeting and Shielding of pDNA Lipopolyplexes via Bivalent Attachment of a Sequence-Defined PEG Agent, Macromol Biosci. 2017 Sep 6. doi: 10.1002/mabi.201700203

• Reinhard, S., Zhang, W., Wagner, E. (2017) Optimized Solid-Phase-Assisted Synthesis of Oleic Acid Containing siRNA Nanocarriers, ChemMedChem. 2017 Sep 7;12(17):1464-1470

• Zhang P, Steinborn B, Lächelt U, Zahler S, Wagner E (2017) Lipo-Oligomer Nanoformulations for Targeted Intracellular Protein Delivery, Biomacromolecules. 2017 Aug 14;18(8):2509-2520
• Moghimi, S.M., Wagner, E. (2017) Nanoparticle Technology: Having Impact, but Needing Further Optimization, Mol Ther. 2017 Jul 5;25(7):1461-1463
• Wang S, Li C, Qian M, Jiang H, Shi W, Chen J, Lächelt U, Wagner E, Lu W, Wang Y, Huang R. (2017) Augmented glioma-targeted theranostics using multifunctional polymer-coated carbon nanodots, Biomaterials. 2017 Oct;141:29-39

• Heller, P., Hobernik, D., Lächelt, U., Schinnerer, M., Weber, B., Schmidt, M., Wagner, E., Bros, M., Barz, M. (2017) Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines, J Control Release. 2017 Jul 28;258:146-160
• Krzysztoń, R., Salem, B., Lee, D.J., Schwake, G., Wagner, E., Rädler, J. O. (2017) Microfluidic Self-Assembly of Folate-Targeted Monomolecular siRNA-Lipid Nanoparticles, Nanoscale. 2017 Jun 8;9(22):7442-7453
• Urnauer, S., Klutz, K., Grünwald, G.K., Morys, S., Schwenk, N., Zach, C., Gildehaus, F.J., Roedl, W., Ogris, M., Wagner, E., Spitzweg, C. (2017) Systemic tumor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes, J Gene Med. 2017 May;19(5)
• Niño-Pariente, A., Armiñán, A., Reinhard, S., Scholz, C., Wagner, E., Vicent, M.J. (2017) Design of Poly-l-Glutamate-Based Complexes for pDNA Delivery, Macromol Biosci. 2017 Oct;17(10). doi: 10.1002/mabi.201700029
• Truebenbach, I., Gorges, J., Kuhn, J., Kern, S., Baratti, E., Kazmaier, U., Wagner, E., Lächelt, U. (2017) Sequence-Defined Oligoamide Drug Conjugates of Pretubulysin and Methotrexate for Folate Receptor Targeted Cancer Therapy, Macromol Biosci. 2017 Oct;17(10). doi: 10.1002/mabi.201600520
• Morys, S., Krhac Levacic, A., Urnauer, S., Kempter, S., Kern, S., Rädler, J.O., Spitzweg, C., Lächelt, U., Wagner, E. (2017) Influence of Defined Hydrophilic Blocks within Oligoaminoamide Copolymers: Compaction versus Shielding of pDNA Nanoparticles, Polymers 2017, 9(4), 142
• Schmohl, K.A., Gupta, A., Grünwald, G.K., Trajkovic-Arsic, M., Klutz, K., Braren, R., Schwaiger, M., Nelson, P.J., Ogris, M., Wagner, E., Siveke, J.T., Spitzweg, C. (2017) Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene, Oncotarget. 2017 May 16;8(20):33393-33404
• Liu X, Zhang P, Rödl W, Maier K, Lächelt U, Wagner E. (2017) Toward Artificial Immunotoxins: Traceless Reversible Conjugation of RNase A with Receptor Targeting and Endosomal Escape Domains, Mol Pharm. 2017 May 1;14(5):1439-1449
• Hall, A., Lächelt, U., Bartek, J., Wagner, E., Moghimi, S.M. (2017) Polyplex Evolution: Understanding Biology, Optimizing Performance, Mol Ther. 2017 Jul 5;25(7):1476-1490

• Heissig, P., Schrimpf, W., Hadwiger, P., Wagner, E., Lamb, D.C. (2017) Monitoring integrity and localization of modified single-stranded RNA oligonucleotides using ultrasensitive fluorescence methods, PLoS One. 2017 Mar 9;12(3):e0173401
• Zhang, P., Wagner, E. (2017) History of Polymeric Gene Delivery Systems, Top Curr Chem (J). 2017 Apr;375(2):26

• Beckert, L., Kostka, L., Kessel, E., Krhac Levacic, A., Kostkova, H., Etrych, T., Lächelt, U., Wagner, E. (2017) Corrigendum to "Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo" [Euro. J. Pharm. Biopharm. 105 (2016) 85-96], Eur J Pharm Biopharm. 2017 Apr;113:240

• Röder, R., Preiß, T., Hirschle, P., Steinborn, B., Zimpel, A., Höhn, M., Rädler, J.O., Bein, T., Wagner, E., Wuttke, S., Lächelt, U. (2017) Multifunctional Nanoparticles by Coordinative Self-Assembly of His-Tagged Units with Metal-Organic Frameworks, J Am Chem Soc. 2017 Feb 15;139(6):2359-2368

• Reinhard, S., Wagner, E. (2017) How to Tackle the Challenge of siRNA Delivery with Sequence-Defined Oligoamino Amides, Macromol Biosci. 2017 Jan;17(1). doi: 10.1002/mabi.201600152
• Röder, R., Helma, J., Preiß, T., Rädler, J.O., Leonhardt, H., Wagner, E. (2017) Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells, Pharm Res. 2017 Jan;34(1):161-174
• Deglmann, C.J., Blazkow-Schmalzbauer, K., Moorkamp, S., Susha, A., Herrler, T., Giunta, R.E., Wagner, E., Rogach, A., Baumeister, R.G.H., Ogris, M. (2017) Cadmium Telluride Quantum Dots as a Fluorescence Marker for Adipose Tissue Grafts, Ann Plast Surg. 2017 Feb;78(2):217-222
• Morys, S., Wagner, E., Lächelt, U. (2016) From Artificial Amino Acids to Sequence-defined Targeted Oligoaminoamides, Methods Mol Biol. 2016;1445:235-58
• Frederickson, R.M., Moghimi, S.M., Wagner, E., Yla-Herttuala, S. (2016) Call for papers: Nanoparticle Development and Applications in Cellular and Molecular Therapies, Mol Ther. 2016 Aug;24(8):1334-5
• Müller, A. M., Schmohl, K.A., Knoop, K., Schug, C., Urnauer, S., Hagenhoff, A., Clevert, D.-A., Ingrisch, M., Niess, H., Carlsen, J., Zach, C., Wagner, E., Bartenstein, P., Nelson, P. J., Spitzweg, C. (2016) Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery, Oncotarget. 2016 Aug 23;7(34):54795-54810
• Sommer, A.-K., Hermawan, A., Mickler, F.M., Ljepoja, B., Knyazev, P., Bräuchle, C., Ullrich, A., Wagner, E., Roidl, A. (2016) Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases, Oncotarget. 2016 Aug 2;7(31):50461-50476
• Müller, K., Klein, P.M., Heissig, P., Roidl, A., Wagner, E. (2016) EGF receptor targeted lipo-oligocation polyplexes for antitumoral siRNA and miRNA delivery, Nanotechnology. 2016 Nov 18;27(46):464001
• Klein, P. M. Reinhard, S., Lee, D.-J., Müller, K., Ponader, D., Hartmann, L., Wagner, E. (2016), Precise redox-sensitive cleavage sites for improved bioactivity of siRNA lipopolyplexes, Nanoscale. 2016 Oct 27;8(42):18098-18104
• Westerhausen, C., Schnitzler, L.G., Wendel, D., Krzysztoń, R., Lächelt, U., Wagner, E., Rädler, J.O., Wixforth, A. (2016) Controllable Acoustic Mixing of Fluids in Microchannels for the Fabrication of Therapeutic Nanoparticles, Micromachines 2016; 7, 150; doi:10.3390/mi7090150
• Lee, D.-J., He, D., Kessel, E., Padari, K., Kempter, S., Lächelt, U., Rädler, J.O., Pooga, M., Wagner, E. (2016) Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes, J Control Release. 2016 Dec 28;244(Pt B):280-291

• Müller, K., Kessel, E., Klein, P.M., Höhn, M., Wagner, E. (2016) Post-PEGylation of siRNA lipo-oligoamino amide polyplexes using tetra-glutamylated folic acid as ligand for receptor-targeted delivery, Mol Pharm. 2016 Jul 5;13(7):2332-45

• Urnauer, S., Morys, S., Krhac Levacic, A., Müller, A.M., Schug, C., Schmohl, K.A., Schwenk, N., Zach, C., Carlsen, J., Bartenstein, P., Wagner, E., Spitzweg, C. (2016) Sequence defined cMET/HGFR-targeted polymers as gene delivery vehicles for the theranostic sodium iodide symporter (NIS) gene, Mol Ther. 2016 Aug;24(8):1395-404

• Zimpel, A., Preiß T., Röder, R., Engelke, H., Ingrisch, M., Peller, M., Rädler, J.O., Wagner, E., Bein, T., Lächelt, U., Wuttke, S. (2016) Imparting Functionality to MOF Nanoparticles by External Surface Selective Covalent Attachment of Polymers, Chem. Mater., 2016, 28 (10), pp 3318–3326

• Schreiber, C., Segerer, F.J., Wagner, E., Roidl, A., Rädler, J.O. (2016) Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration, Sci Rep. 2016 May 31;6:26858
• Zhang, W., Müller, K., Kessel, E., Reinhard, S., He, D., Klein, P.M., Höhn, M., Rödl, W., Kempter, S., Wagner, E. (2016) Targeted siRNA Delivery Using a Lipo-Oligoaminoamide Nano-Core with an Influenza Peptide and Transferrin Shell, Adv Healthc Mater. 2016 Jun;5(12):1493-504
• Beckert, L., Kostka, L., Kessel, E., Krhac Levacic, A., Kostkova, H., Etrych, T., Lächelt, U., Wagner, E. (2016) Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo, Eur. J. Pharm. Biopharm. 105, 85–96
• Jiang, Q., Yue, D., Nie, Y., Xu, X., He, Y., Zhang, S., Wagner, E., Gu, Z. (2016) Specially-Made Lipid-based Assemblies for Improving Transmembrane Gene Delivery: Comparison of Basic Amino Acid Residues-Rich Periphery, Mol Pharm. 2016 Jun 6;13(6):1809-21
• Heissig, P., Klein, P.M., Hadwiger, P., Wagner, E. (2016) DNA as tunable adaptor for siRNA polyplex stabilization and functionalization, Mol Ther Nucleic Acids. 2016 Mar 1;5:e288
• He, D., Müller, K., Krhac Levacic, A., Kos, P., Lächelt, U., Wagner, E. (2016) Combinatorial optimization of sequence-defined oligo(ethanamino)amides for folate receptor-targeted pDNA and siRNA delivery. Bioconjugate Chem., 2016, 27 (3):647–659
• Möller, K., Müller, K., Engelke, H., Bräuchle, C., Wagner, E., Bein, T. (2016) Highly Efficient siRNA Delivery from Core-Shell Mesoporous Silica Nanoparticles with Multifunctional Polymer Caps. Nanoscale, 2016,8:4007-4019
• Liu, X., Zhang, P., He, D., Rödl, W., Preiß, T., Rädler, J., Wagner, E., Lächelt, U. (2016) pH-reversible cationic RNase A conjugates for enhanced cellular delivery and tumor cell killing. Biomacromolecules, 2016, 17 (1):173–182

• Hermawan, A., Wagner, E., Roidl, A. (2016) Consecutive salinomycin treatment reduces doxorubicin resistance of breast tumor cells by diminishing drug efflux pump expression and activity. Oncol Rep. 2016 Mar;35(3):1732-40
• Lee, D.J., Kessel, E., Edinger, D., He, D., Klein, P.M., Voith von Voithenberg, L., Lamb, D.C., Lächelt, U., Lehto, T., Wagner, E. (2016) Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand, Biomaterials. 2016 Jan;77:98-110

• Leclercq, L., Reinhard, S., Chamieh, J., Döblinger, M., Wagner, E., Cottet, H. (2015) Fast Characterization of Polyplexes by Taylor Dispersion Analysis, Macromolecules. 2015, 48 (19):7216–7221
• Zhang, P., He, D., Klein, P., Liu, X., Röder, R., Döblinger, M., Wagner, E.(2015) Enhanced Intracellular Protein Transduction by Sequence Defined Tetra-Oleoyl Oligoaminoamides Targeted for Cancer Therapy, Adv. Funct. Materials. 2015 Nov 11; 25:6627–6636

• Zhang, W., Rödl, W., He, D., Döblinger, M., Lächelt, U., Wagner, E. (2015) Combination of sequence-defined oligoaminoamides with transferrin-polycation conjugates for receptor-targeted gene delivery, J Gene Med. 2015 Aug 9;17(8-9):161-72

• Urbiola, K., Blanco-Fernández, L., Navarro, G., Rödl, W., Wagner, E., Ogris, M., Tros de Ilarduya, C. (2015) Evaluation of improved PAMAM-G5 conjugates for gene delivery targeted to the transferrin receptor, Eur J Pharm Biopharm. 2015 Aug;94:116-22

• Wagner, E. (2015) Tumorspezifischer Transfer von Anti-microRNA zur Krebstherapie - pHLIP ist der Schlüssel, Angew. Chem.127, 5918 – 5920
• Wagner, E. (2015) Tumor-targeted Delivery of Anti-microRNA for Cancer Therapy: pHLIP is Key, Angew Chem Int Ed Engl. 2015 May 11;54(20):5824-6

• Greißel, A., Culmes, M., Napieralski, R., Wagner, E., Gebhard; H., Schmitt, M., Zimmermann, A., Eckstein, H.-H., Zernecke, A., Pelisek, J. (2015) Alternation of histone and DNA methylation in human atherosclerotic carotid plaques, Thromb Haemost. 2015 Aug;114(2):390-402

• An S, He D, Wagner E, Jiang C. (2015) Peptide-like Polymers Exerting Effective Glioma-Targeted siRNA Delivery and Release for Therapeutic Application, Small. 2015 Oct;11(38):5142-50

• Weber J, Lächelt U, Wagner E. (2015) Multifunctional Oligoaminoamides for the Receptor-Specific Delivery of Therapeutic RNA, Methods Mol Biol. 2015;1324:369-86
• Broda E, Mickler FM, Lächelt U, Morys S, Wagner E, Bräuchle C. (2015) Assessing potential peptide targeting ligands by quantification of cellular adhesion of model nanoparticles under flow conditions, J Control Release. 2015 Jun 29;213:79-85
• Niedermayer, S., Weiss, V., Herrmann, A., Schmidt, A., Datz, S., Müller, K., Wagner, E., Bein, T., Bräuchle, C. (2015) Multifunctional Polymer-Capped Mesoporous Silica Nanoparticles for pH-Responsive Targeted Drug Delivery, Nanoscale. 2015 Apr 24;7(17):7953-64
• Lächelt, U., Wagner, E. (2015) Nucleic Acid Therapeutics Using Polyplexes – A Journey of 50 Years (and Beyond), Chem Rev. 2015 Oct 14;115(19):11043-78
• He, D., Wagner, E. (2015) Defined Polymeric Materials for Gene Delivery, Macromol Biosci. 2015 May;15(5):600-12
• Klein PM, Müller K, Gutmann C, Kos P, Krhac Levacic A, Edinger D, Höhn M, Leroux JC, Gauthier MA, Wagner E (2015) Twin disulfides as opportunity for improving stability and transfection efficiency of oligoaminoethane polyplexes, J Control Release. 2015 May 10;205:109-19
• Knoop, K., Schwenk, N., Schmohl, K., Müller, A., Zach, C., Cyran, C., Carlsen, J., Böning, G., Bartenstein, P., Göke, B., Wagner, E., Nelson, P.J., Spitzweg, C. (2015) Mesenchymal stem cell (MSC)-mediated, tumor stroma-targeted radioiodine therapy of metastatic colon cancer using the sodium iodide symporter as theranostic gene, J Nucl Med. 2015 Apr;56(4):600-6

• Kos, P., Lächelt, U., Herrmann, A., Mickler, F.M., Döblinger, M., He, D., Krhač Levačić, A., Morys, S., Bräuchle C, Wagner, E. (2015) Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer, Nanoscale. 2015 Mar 12;7(12):5350-62
• Jorge, A.F., Röder, R., Kos, P., Dias, R.S., Wagner, E., Pais, A.A. (2015) Combining polyethylenimine and Fe(III) for mediating pDNA transfection, Biochim Biophys Acta. 2015 Jun;1850(6):1325-35
• Kos, P., Lächelt, U., He, D., Nie, Y., Gu, Z., Wagner, E. (2015) Dual-Targeted Polyplexes Based on Sequence-Defined Peptide-PEG-Oligoaminoamides, J Pharm Sci. 2015 Feb;104(2):464-75
• Lee, D.-J., Wagner, E., Lehto, T. (2015) Sequence-defined oligoaminoamides for the delivery of siRNAs, Methods Mol Biol. 2015;1206:15-27
• Menhofer, M.H., Bartel, D., Kubisch, R., Busse, J., Wagner, E., Müller, R., Vollmar, A.M., Zahler, S. (2014) In vitro and in vivo characterization of the actin polymerizing compound Chondramide as angiogenic inhibitor, Cardiovasc Res. 2014 Nov 1;104(2):303-14
• Menhofer, M.H., Kubisch, R., Schreiner, L., Zorn, M., Foerster, F., Mueller, R., Raedler, J.O., Wagner, E., Vollmar, A.M., Zahler, S. (2014) The actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractility, PLoS One. 2014 Nov 12;9(11):e112542
• Kopp, F., Hermawan, A., Oak, P.S., Ulaganathan, V.K., Herrmann, A., Elnikhely, N., Thakur, C., Xiao, Z., Knyazev, P., Ataseven, B., Savai, R., Wagner, E., Roidl, A. (2014) Sequential Salinomycin Treatment Results in Resistance Formation through Clonal Selection of Epithelial-Like Tumor Cells, Transl Oncol. 2014 Dec;7(6):702-11
• Wagner, E. (2014) Polymers for Nucleic Acid Transfer — An Overview, Adv Genet. 2014;88:231-61
• Lehto, T., Wagner, E. (2014) Sequence-defined polymers for the delivery of oligonucleotides, Nanomedicine (Lond). 2014 Dec;9(18):2843-59
• Foerster F, Braig S, Moser C, Kubisch R, Busse J, Wagner E, Schmoeckel E, Mayr D, Schmitt S, Huettel S, Zischka H, Mueller R, Vollmar AM (2014) Targeting the actin cytoskeleton: selective antitumor action via trapping PKCɛ, Cell Death Dis. 2014 Aug 28;5:e1398
• Röder, R., Wagner, E. (2014) Sequence-defined shuttles for targeted nucleic acid and protein delivery, Ther Deliv. 2014 Sep;5(9):1025-45
• Klein, P., Wagner, E. (2014) Bioreducible Polycations as Shuttles for Therapeutic Nucleic Acid and Protein Transfection, Antioxid Redox Signal. 2014 Aug 10;21(5):804-17
• Lächelt U, Wittmann V, Müller K, Edinger D, Kos P, Höhn M, Wagner E (2014) Synthetic Polyglutamylation of Dual-Functional MTX Ligands for Enhanced Combined Cytotoxicity of Poly(I:C) Nanoplexes, Mol Pharm. 2014 Aug 4;11(8):2631-9
• Wang Y, Wang K, Zhang R, Liu X, Yan X, Wang J, Wagner E, Huang R (2014) Synthesis of Core-Shell Graphitic Carbon@Silica Nanospheres with Dual-Ordered Mesopores for Cancer-Targeted Photothermochemotherapy, ACS Nano. 2014 Aug 26;8(8):7870-9

• Wagner, E. (2014) Nucleic Acid Medicines: The Polymer Option. Encyclopedia of Polymeric Nanomaterials, DOI 10.1007/978-3-642-36199-9_267-1

• Noga M, Edinger D, Wagner E, Winter G, Besheer A (2014) Stability and activity of hydroxyethyl starch-coated polyplexes in frozen solutions or lyophilizates, Int J Pharm. 2014 Jul 20;469(1):50-8
  Noga M, Edinger D, Wagner E, Winter G, Besheer A (2014) Characterization and compatibility of hydroxyethyl starch-polyethylenimine copolymers for DNA delivery, J Biomater Sci Polym Ed. 2014;25(9):855-71
• Edinger, D., Kläger, R., Troiber, C., Dohmen, C., Wagner, E. (2014) Gene Silencing and Antitumoral Effects of Eg5 or Ran siRNA Oligoaminoamide Polyplexes, Drug Deliv Transl Res 4 (1), 84-95
• Salcher, E.E., Wagner, E. (2014) Nano-encapsulation of Oligonucleotides for Therapeutic Use, Nucleic Acid Nanotechnology, Nucleic Acids and Molecular Biology 29, 245-260
• Schempp CM, von Schwarzenberg K, Schreiner L, Kubisch R, Müller R, Wagner E, Vollmar AM (2014) V-ATPase Inhibition Regulates Anoikis Resistance and Metastasis of Cancer Cells, Mol Cancer Ther. 2014 Apr;13(4):926-37
• Hütz, K., Mejías-Luque, R., Farkasova, K., Ogris, M., Krebs, S., Anton, M., Vieth, M., Schüller, U., Schneider, M.R., Blum, H., Wagner, E., Jung, A., Gerhard, M. (2014) The stem cell factor Sox2 regulates the tumorigenic potential in human gastric cancer cells, Carcinogenesis. 2014 Apr;35(4):942-50

• Braig, S., Wiedmann, R. M., Liebl, J., Singer, M., Kubisch, R., Schreiner, L., Abhari, B. A., Wagner, E., Kazmaier, U., Fulda S., Vollmar, A. M. (2014) Pretubulysin: a new option for the treatment of metastatic cancer, Cell Death Dis. 2014 Jan 16;5:e1001

• Kubisch R, Fröhlich T, Arnold GJ, Schreiner L, von Schwarzenberg K, Roidl A, Vollmar AM, Wagner E (2014) V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo, Int J Cancer. 2014 May 15;134(10):2478-88
• Kopp F, Wagner E, Roidl A (2014) The proto-oncogene KRAS is targeted by miR-200c, Oncotarget. 2014 Jan;5(1):185-95

• Wang J, Lei Y, Xie C, Lu W, Wagner E, Xie Z, Gao J, Zhang X, Yan Z, Liu M (2014) Retro-inverso CendR peptide-mediated polyethyleneimine for intracranial glioblastoma-targeting gene therapy, Bioconjug Chem. 2014 Feb 19;25(2):414-23
• Kopp F, Hermawan A, Oak PS, Herrmann A, Wagner E, Roidl A (2014) Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migration, Mol Cancer. 2014 Jan 27;13:16
• Scholz C, Kos P,Wagner E. (2014) Comb-Like Oligoaminoethane Carriers: Change in Topology Improves pDNA Delivery. Bioconjug Chem. 2014 Feb 19;25(2):251-61
• Scholz C, Kos P, Leclercq L, Jin X, Cottet H, Wagner E. (2014) Correlation of Length of Linear Oligo(ethanamino) Amides with Gene Transfer and Cytotoxicity. ChemMedChem. 2014 Sep;9(9):2104-10
• Murayama S, Kos P,Miyata K, Kataoka K, Wagner E, Kato M. (2014) Gene Regulation by Intracellular Delivery and Photodegradation of Nanoparticles Containing Small Interfering RNA, Macromol Biosci. 2014 May;14(5):626-31
• Zhang CY, Kos P, Müller K, Schrimpf W, Troiber C, Lächelt U, Scholz C, Lamb DC, Wagner E., (2014) Native chemical ligation for conversion of sequence-defined oligomers into targeted pDNA and siRNA carriers. , J Control Release. 2014 Apr 28;180:42-50

• Lächelt, U., Kos, P. Mickler, F.M., Herrmann, A., Salcher, E.E., Rödl, W., Badgujar, N., Bräuchle, C., Wagner, E., (2014) Fine-tuning of proton sponges by precise diaminoethanes and histidines in pDNA polyplexes, Nanomedicine. 2014 Jan;10(1):35-44
• Kos, P., Scholz, C., Salcher, E.E., Herrmann, A., Wagner, E. (2013) Gene transfer with sequence-defined oligo(ethanamino)amides bioreducibly attached to a polypropylenimine dendrimer core, Pharm Nanotechnology 1, 269-281
• Kasper, J., Troiber, C., Küchler, S., Wagner, E., Friess, W. (2013) Formulation development of lyophilized, long-term stable siRNA/oligoaminoamide polyplexes, Eur J Pharm Biopharm. 2013 Oct;85(2):294-305
• Grünwald, G.K., Vetter, A., Klutz, K., Willhauck, M.J., Schwenk, N., Senekowitsch-Schmidtke, R., Schwaiger, M., Zach, C., Wagner, E., Göke, B., Holm, P.S., Ogris, M., Spitzweg, C. (2013) EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene, Mol Ther Nucleic Acids. 2013 Nov 5;2:e131
• Bogomilova, A., Höhn, M., Günther, M., Herrmann, A., Troev, K., Wagner, E., Schreiner, L. (2013) A polyphosphoester conjugate of melphalan as antitumoral agent, Eur J Pharm Sci. 2013 Nov 20;50(3-4):410-9
• Kopp, F., Schnoedt, M., Haase, R., Wagner, E., Roidl, A., Ogris, M. (2013) De-targeting by miR-143 decreases unwanted transgene expression in non-tumorigenic cells, Gene Ther. 20, 1104-1109
• Lei, Y., Wang, J., Xie, C., Wagner, E., Lu, W., Li, Y., Wei, X., Dong, J., Liu, M. (2013) Glutathione-sensitive RGD-Poly(ethylene glycol)-SS-Polyethylenimine for intracranial glioblastoma targeted gene delivery, J Gene Med. 2013 Aug;15(8-9):291-305
• Haase, R., Magnusson, T., Su, B., Kopp, F., Wagner, E., Lipps, H., Baiker, A., Ogris, M. (2013) Generation of a tumor- and tissue-specific episomal non-viral vector system, BMC Biotechnol. 2013 Jun 4;13:49
• Wagner, E. (2013) Biomaterials in RNA therapeutics: Quo vadis? Biomater. Sci. 1, 804–809
• Viola, J.R., Rafael, D.F., Wagner, E., Besch, R., Ogris, M. (2013) Gene therapy for advanced melanoma: selective targeting and therapeutic nucleic acids, J Drug Deliv. 2013;2013:897348
• Kos, P., Wagner, E. (2013) Polymers for siRNA Delivery: Combining precision with multifunctionality, Chimica Oggi - Chemistry Today 31(2), 6-10
• Grünwald, G.K., Vetter, A., Klutz, K., Willhauck, M.J., Schwenk, N., Senekowitsch-Schmidtke, R., Schwaiger, M., Zach, C., Wagner, E., Göke, B., Holm, P.S., Ogris, M., Spitzweg, C. (2013) Systemic image-guided liver cancer radiovirotherapy using dendrimer-coated adenovirus encoding the sodium iodide symporter as theranostic gene, J Nucl Med. 2013 Aug;54(8):1450-7
• Marfels, C., Hoehn, M., Wagner, E., Günther, M. (2013) Characterization of in vivo chemoresistant human hepatocellular carcinoma cells with transendothelial differentiation capacities, BMC Cancer. 2013 Apr 2;13:176
• Vetter, A., Virdi, K., Espenlaub, S., Rödl, W., Wagner, E., Holm, P., Scheu, C., Kreppel, F., Spitzweg, C., Ogris, M. (2013) Adenoviral vectors coated with PAMAM dendrimer conjugates allow CAR independent virus uptake and targeting to the EGF Receptor, Mol Pharm. 2013 Feb 4;10(2):606-18
• Noga, M., Edinger, D., Kläger, R., Wegner, S.V., Spatz, J.P., Wagner, E., Winter, G., Besheer, A. (2013) The effect of molar mass and degree of hydroxyethylation on the controlled shielding and deshielding of hydroxyethyl starch-coated polyplexes, Biomaterials. 2013 Mar;34(10):2530-8
• Kubisch, R., Meissner, L., Krebs, S., Blum, H., Günther, M., Roidl, A., Wagner, E. (2013) A comprehensive gene expression analysis of resistance formation upon metronomic cyclophosphamide therapy, Transl Oncol. 2013 Feb;6(1):1-9
• Knoop, K., Schwenk, N., Dolp, P., Willhauck, M.J., Zischek, C., Zach, C., Hacker, M., Göke, B., Wagner, E., Nelson, P.J., Spitzweg, C. (2013) Stromal targeting of sodium iodide symporter using mesenchymal stem cells allows enhanced imaging and therapy of hepatocellular carcinoma, Hum Gene Ther. 2013 Mar;24(3):306-16
• Li, Y., Lei, Y., Wagner, E., Xie, C., Lu, W., Zhu, J., Shen, J., Wang, J., Liu, M. (2013) A Potent Retro-Inverso D-peptide for Simultaneous Targeting Angiogenic Blood Vasculature and Tumor Cells, Bioconjug Chem. 2013 Jan 16;24(1):133-43
• Culmes, M., Pelisek, J., Burgkart, R., Nüssler, A. K., Guenther, M., Wagner, E., Eckstein, H.-H. (2013) Endothelial differentiation of adipose-derived mesenchymal stem cells is improved by epigenetic modifying drug BIX-01294, EurJ Cell Biol. 2013 Feb;92(2):70-9
• Su, B., Cengizeroglu, A., Farkasova, K., Anton, M., Ellwart, J.W., Haase, R., Wagner, E., Ogris, M. (2013) Systemic TNF alpha gene therapy synergizes with liposomal doxorubicine in the treatment of metastatic cancer, Mol Ther. 2013 Feb;21(2):300-8

• Rödl, W., Schaffert, D., Wagner, E., Ogris, M. (2013) Synthesis of polyethylenimine based nanocarriers for systemic tumor targeting of nucleic acids, Methods Mol Biol. 2013;948:105-20.

• Troiber, C., Kasper, J.C., Milani, S., Scheible, M., Martin, I., Schaubhut, F., Küchler, S., Rädler, J., Simmel, F.C., Friess, W., Wagner, E. (2013) Comparison of four different particle sizing methods for siRNA polyplex characterization, Eur J Pharm Biopharm. 2013 Jun;84(2):255-64

• Troiber, C., Edinger, D., Kos, P., Schreiner, L., Kläger, R., Herrmann, A., Wagner, E. (2013) Stabilizing effect of tyrosine trimers on pDNA and siRNA polyplexes, Biomaterials. 2013; 34:1624-1633

• Terziyska, N., Castro Alves, C., Groiss, V., Schneider, K., Farkasova, K., Ogris, M., Wagner, E., Ehrhardt, H., Brentjens, R.J., zur Stadt, U., Horstmann, M., Quintanilla-Martinez, L., Jeremias, I. (2012) In Vivo Imaging Enables High Resolution Preclinical Trials on Patients’ Leukemia Cells Growing in Mice, PLoS One. 2012;7(12):e52798
• Rath, S., Liebl, J., Fürst, R., Ullrich, A., Burkhart, J.L., Kazmaier, U., Herrmann, J., Müller, R., Günther, M., Schreiner, L., Wagner, E., Vollmar, A.M., Zahler, S. (2012) Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives, Br J Pharmacol. 2012 Nov;167(5):1048-61
• Kopp, F., Oak, P., Wagner, E., Roidl, A. (2012) miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression, PLoS One. 2012;7(11):e50469
• Oak, P. S., Kopp, F., Thakur, C., Ellwart, J. W., Rapp, U. R., Ullrich, A., Wagner, E., Knyazev, P., Roidl, A. (2012) Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells, Int J Cancer. 2012 Dec 15;131(12):2808-19
• Salcher, E. E., Kos, P., Fröhlich, T., Badgujar, N., Scheible, M., Wagner, E., (2012) Sequence-definded Four-arm Oligo(ethanamino)amides for pDNA and siRNA Delivery: Impact of Building Blocks on Efficacy, J Control Release. 2012 Dec 28;164(3):380-6
• Fröhlich, T., Edinger, D., Russ, V., Wagner, E. (2012) Stabilization of Polyplexes via Polymer Crosslinking for Efficient siRNA Delivery, Eur J Pharm Sci. 2012 Dec 18;47(5):914-20
• Wiedmann, R.M., von Schwarzenberg, K. Palamidessi, A., Schreiner, L., Kubisch, R., Liebl, J., Schempp, C., Trauner, D., Vereb, G., Zahler, S., Wagner, E., Muller, R., Scita, G., Vollmar, A.M. (2012) The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1, Cancer Res. 2012 Nov 15;72(22):5976-5987
• Maier, K., Martin, I., Wagner, E. (2012) Sequence Defined Disulfide-linked Shuttle for Strongly Enhanced Intracellular Protein Delivery, Mol Pharm. 2012 9:3560−3568

• Dohmen, C., Edinger, D., Froehlich, T., Schreiner, L., Laechelt, U., Troiber, C., Rädler, J., Hadwiger, P., Vornlocher, H. P., Wagner, E. (2012) Nano Sized Multifunctional Polyplexes for Receptor Mediated SIRNA Delivery, ACS Nano. 2012 Jun 26;6(6):5198-208

• Mickler, F. M., Moeckl, L., Ruthardt, N., Ogris, M., Wagner, E., Bräuchle, C., (2012) Tuning nanoparticle uptake: Live-cell imaging reveals two endocytosis mechanisms mediated by natural and artificial EGFR targeting ligand, Nano Lett. 2012 Jul 11;12(7):3417-23

• Maier, K., Wagner, E., (2012) Acid-labile traceless click linker for protein transduction, J Am Chem Soc. 2012 Jun 20;134(24):10169-73

• Schaffert, D., Troiber, C., Wagner, E., (2012) New Sequence-Defined Polyaminoamides with Endosomolytic Properties for Plasmid DNA Delivery, Bioconjug Chem. 2012; 23:1157-1165
• Fröhlich, T., Edinger, D., Kläger, R., Troiber, C., Salcher, E., Badgujar, N., Martin, I., Schaffert, D., Cengizeroglu, A., Hadwiger, P., Vornlocher, H. P., Wagner, E., (2012) Structure-activity relationships of siRNA carriers based on sequence-defined olige(ethaneamino) amides, J Control Release. 2012 Jun 28;160(3):532-41
• Martin, I., Dohmen, C., Mas- Moruno, C., Troiber, C., Kos, P., Schaffert, D., Lächelt, U., Teixidó, M., Günther, M., Kessler, H., Giralt, E., Wagner, E., (2012) Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery, Org Biomol Chem. 2012 Apr 28;10(16):3258-68
• Abourbeh, G., Shir, A., Mishani, E., Ogris, M., Rödl, W., Wagner, E., Levitzki, A. (2012) PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors, IUBMB Life. 2012 Apr;64(4):324-30

• Bogomilova, A., Günther, M., Wagner, E., Hägele, G., Troev, K. (2012) Synthesis and Characterization of New Platinum (II) Phosphinate Complexes, J. Coord. Chem. 2012; 65:1093-1106

• Ogris, M., Wagner, E. (2012) Synthesis of linear polyethylenimine and use in transfection (2012), Cold Spring Harb Protoc. 2012 Feb 1;2012(2):246-50
• Noga, M., Edinger, D., Rödl, W., Wagner, E., Winter, G., Besheer, A. (2012) Controlled shielding and deshielding of gene delivery polyplexes using hydroxyethyl starch (HES) and alpha-amylase, J control Release. 2012 Apr 10;159(1):92-103
• Wagner, E. (2012) Polymers for siRNA Delivery: Inspired by Viruses to be Targeted, Dynamic, and Precise, ACC Chem Res. 2012 Jul 17;45(7):1005-13
• Wagner, E. (2012) Functional Polymer Conjugates for Medicinal Nucleic Acid Delivery, Adv Polymer Sci. 2012; 247:1–30
• Dohmen, C., Fröhlich, T., Lächelt, U., Röhl, I., Vornlocher, H.-P., Hadwiger, P., Wagner, E. (2012) Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing, Molecular Therapy Nucleic Acids 2012; 1 e7:1-6
• Scholz, C., Wagner, E. (2012) Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers, J Control Release. 2012 Jul 20;161(2):554-65
• Klutz, K., Willhauck, M.J., Dohmen, C., Wunderlich, N., Knoop, K., Zach, C., Senekowitsch-Schmidtke, R., Gildehaus, F.J., Ziegler, S., Fürst, S., Göke, B., Wagner, E., Ogris, M., Spitzweg, C. (2011) Image-guided tumor-selective radioiodine therapy of liver cancer after systemic nonviral delivery of the sodium iodide symporter gene, Hum Gene Ther. 2011 Dec;22(12):1563-74
• Knoop, K., Kolokythas, M., Klutz, K., Willhauck, M.J., Wunderlich, N., Draganovici, D., Zach, C., Gildehaus, F.J., Böning, G., Göke, B., Wagner, E., Nelson, P.J., Spitzweg, C. (2011) Image-guided, Tumor Stroma-targeted (131)I Therapy of Hepatocellular Cancer After Systemic Mesenchymal Stem Cell-mediated NIS Gene Delivery, Mol Ther. 2011 Sep;19(9):1704-13
• Troiber, C., Wagner, E. (2011) Nucleic Acid carriers based on precise polymer conjugates, Bioconjug Chem. 2011 Sep 21;22(9):1737-52
• Schaffert, D., Troiber, C., Salcher, E., Fröhlich, T., Martin, I., Badgujar, N., Dohmen, C., Edinger, D., Kläger, R., Maiwald, G., Farkasova, K., Seeber, S., Jahn-Hofmann, K., Hadwiger, P., Wagner, E. (2011) Solid-phase synthesis of sequence-defined T-, i-, and U-shape polymers for pDNA and siRNA delivery, Angew Chem Int Ed Engl. 2011 Sep 12;50(38):8986-9
• Schaffert, D., Troiber, C., Salcher, E.E., Fröhlich, T., Martin, I., Badgujar, N., Dohmen, C., Edinger, D., Kläger, R., Maiwald, G., Farkasova, K., Seeber, S., Jahn-Hofmann, K., Hadwiger, P., Wagner, E. (2011) Festphasen-basierte Synthese sequenzdefinierter T-, i- und U-Form-Polymere für den pDNA- und siRNA-Transfer. Angew. Chem. 123, 9149 –9152
• Lächelt, U., Wagner, E. (2011) Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers, Frontiers Chem. Science Eng. 2011, 5: 275–286
• Schlossbauer, A., Dohmen, C., Schaffert, D., Wagner, E., Bein, T. (2011) pH-Responsive Release of Acetal-Linked Melittin from SBA-15 Mesoporous Silica, Angew Chem Int Ed Engl. 2011 Jul 18;50(30):6828-30
• Magnusson, T., Haase, R., Schleef, M., Wagner, E., Ogris, M. (2011) Sustained, high transgene expression in liver with plasmid vectors using optimized promoter-enhancer combinations, J Gene Med. 2011 Jul;13(7-8):382-91
• Ogris, M., Wagner, E. (2011) To be targeted: is the magic bullet concept a viable option for synthetic nucleic Acid therapeutics?, Hum Gene Ther. 2011 Jul;22(7):799-807
• Shir, A., Levitzki, A., Wagner, E., Ogris, M. (2011) Nucleic Acid-Based Therapeutics For Glioblastoma, Anticancer Agents Med Chem. 2011 Oct;11(8):693-9
• Yu, H., Nie, Y., Dohmen, C., Li, Y., Wagner, E. (2011) Epidermal Growth Factor-PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry, Biomacromolecules. 2011 Jun 13;12(6):2039-47
• Nie, Y., Schaffert, D., Rödl, W., Ogris, M., Wagner, E., Günther, M. (2011) Dual-targeted polyplexes: One step towards a synthetic virus for cancer gene therapy, J Control Release. 2011 May 30;152(1):127-34
• Dussmann, P., Pagel, J.I., Vogel, S., Magnusson, T., Zimmermann, R., Wagner, E., Schaper, W., Ogris, M., Deindl, E. (2011) Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healing, BMC Dev Biol. 2011 May 20;11(1):28
• Kasper, J.C., Schaffert, D., Ogris, M., Wagner, E., Friess, W. (2011) Development of a lyophilized plasmid/LPEI polyplex formulation with long-term stability-A step closer from promising technology to application, J Control Release. 2011 May 10;151(3):246-55
• Schaffert, D., Kiss, M., Rödl, W., Shir, A., Levitzki, A., Ogris, M., Wagner, E. (2011) Poly(I:C)-Mediated Tumor Growth Suppression in EGF-Receptor Overexpressing Tumors Using EGF-Polyethylene Glycol-Linear Polyethylenimine as Carrier, Pharm Res. 2011 Apr;28(4):731-41
• Schaffert, D., Badgujar, N., Wagner, E. (2011) Novel Fmoc-Polyamino Acids for Solid-Phase Synthesis of Defined Polyamidoamines, Org Lett. 2011 Apr 1;13(7):1586-9
• Philipp, A., Meyer, M., Zintchenko, A., Wagner, E. (2011) Functional modification of amide-crosslinked oligoethylenimine for improved siRNA delivery, React. Funct. Polym. 2011;71:288-293
• Klutz, K., Schaffert, D., Willhauck, M.J., Grünwald, G.K., Haase, R., Wunderlich, N., Zach, C., Gildehaus, F.J., Senekowitsch-Schmidtke, R., Göke, B., Wagner, E., Ogris, M., Spitzweg, C. (2011) Epidermal Growth Factor Receptor-targeted (131)I-therapy of Liver Cancer Following Systemic Delivery of the Sodium Iodide Symporter Gene, Mol Ther. 2011 Apr;19(4):676-85
• Schäfer, A., Pahnke, A., Schaffert, D., van Weerden, W.M., de Ridder, C.M., Rödl, W., Vetter, A., Spitzweg, C., Kraaij, R., Wagner, E., Ogris, M. (2011) Disconnecting the Yin and Yang Relation of Epidermal Growth Factor Receptor (EGFR)-Mediated Delivery: A Fully Synthetic, EGFR-Targeted Gene Transfer System Avoiding Receptor Activation, Hum Gene Ther. 2011 Dec;22(12):1463-73
• Dohmen, C., Wagner, E. (2011) Multifunctional CPP polymer system for tumor-targeted pDNA and siRNA delivery, Methods Mol Biol. 2011;683:453-63
• Nie, Y., Günther, M., Gu, Z., Wagner, E. (2011) Pyridylhydrazone-based PEGylation for pH-reversible lipopolyplex shielding, Biomaterials. 2011 Jan;32(3):858-69
• Kasper, J.C., Schaffert, D., Ogris, M., Wagner, E., Friess, W. (2011) The establishment of an up-scaled micro-mixer method allows the standardized and reproducible preparation of well-defined plasmid/LPEI polyplexes, Eur J Pharm Biopharm. 2011 Jan;77(1):182-5
• Shir, A., Ogris, M., Rödl, W., Wagner, E., Levitzki, A. (2011) EGFR-homing dsRNA activates cancer targeted immune response and eliminates disseminated EGFR over-expressing tumors in mice, Clin Cancer Res. 2011 Mar 1;17(5):1033-43
• Edinger, D., Wagner, E. (2011) Bioresponsive polymers for the delivery of therapeutic nucleic acids, Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jan;3(1):33-46
• Salcher, E., Wagner, E. (2010) Chemically programmed polymers for targeted DNA and siRNA transfection Topics in Current Chemistry 2010; 296:227-249
• Oskuee, R.K., Philipp, A., Dehshahri, A., Wagner, E., Ramezani, M. (2010) The impact of carboxyalkylation of branched polyethylenimine on effectiveness in small interfering RNA delivery, J Gene Med. 2010 Sep;12(9):729-38
• Berg, K., Weyergang, A., Prasmickaite, L., Bonsted, A., Høgset, A.., Strand, M.T., Wagner, E., Selbo, P.K. (2010) Photochemical internalization (PCI): a technology for drug delivery, Methods Mol Biol. 2010;635:133-45
• Rupprecht, S., Hagedorn, C,, Seruggia, D., Magnusson, T., Wagner, E., Ogris, M., Lipps, H.J. (2010)Controlled removal of a nonviral episomal vector from transfected cells, Gene. 2010 Oct 15;466(1-2):36-42
• Navarro, G., Maiwald, G., Haase, R., Rogach, A.L., Wagner, E., de Ilarduya C.T., Ogris, M. (2010) Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery, J Control Release. 2010 Aug 17;146(1):99-105
• Espenlaub, S., Corjon, S., Engler, T., Fella, C., Ogris, M., Wagner, E., Kochanek, S., Kreppel, F. (2010)Capsomere-specific fluorescent labeling of adenovirus vector particles allows for detailed analysis of intracellular particle trafficking and of the performance of bioresponsive bonds for vector capsid modifications, Hum Gene Ther. 2010 Sep;21(9):1155-67
• Cardoso, A.L., Costa, P., de Almeida, L.P., Simões, S., Plesnila, N., Culmsee, C., Wagner, E., de Lima, M.C. (2010) Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo, J Control Release. 2010 Mar 19;142(3):392-403
• Fröhlich, T., Wagner, E. (2010) Peptide- and polymer-based delivery of therapeutic RNA, Soft matter. 2010; 6(2):226-234
• Thoenes, L., Höhn, M., Kashirin, R., Ogris, M., Arnold, G.J., Wagner, E., Günther, M. (2010) In vivo chemoresistance of prostate cancer in metronomic cyclophosphamide therapy, J Proteomics. 2010 May 7;73(7):1342-54
• Ruß, V., Fröhlich, T., Li, Y., Halama, A., Ogris, M., Wagner, E. (2010) Improved in vivo gene transfer into tumor tissue by stabilization of pseudodendritic oligoethylenimine-based polyplexes, J Gene Med. 2010 Feb;12(2):180-93
• Buyens, K., Meyer, M., Wagner, E., Demeester, J., De Smedt, S.C., Sanders, N.N. (2010) Monitoring the disassembly of siRNA polyplexes in serum is crucial for predicting their biological efficacy, J Control Release. 2010 Jan 4;141(1):38-41
• Zintchenko, A., Susha, A.S., Concia, M., Feldmann, J., Wagner, E., Rogach, A.L., Ogris, M. (2009) Drug Nanocarriers Labeled With Near-infrared-emitting Quantum Dots (Quantoplexes): Imaging Fast Dynamics of Distribution in Living Animals, Mol Ther. 2009 Nov;17(11):1849-56
• Philipp, A., Zhao, X., Tarcha, P., Wagner, E., Zintchenko, A. (2009) Hydrophobically Modified Oligoethylenimines as Highly Efficient Transfection Agents for siRNA Delivery, Bioconjug Chem. 2009 Nov 18;20(11):2055-2061
• Klutz, K., Ruß, V., Willhauck, M.J., Wunderlich, N., Zach, C., Gildehaus, F.J., Göke, B., Wagner, E., Ogris, M., Spitzweg, C. (2009) Targeted radioiodine therapy of neuroblastoma tumors following systemic nonviral delivery of the sodium iodide symporter gene, Clin Cancer Res. 2009 Oct 1;15(19):6079-86
• Yu, H., Ruß, V., Wagner, E. (2009) Influence of the Molecular Weight of Bioreducible Oligoethylenimine Conjugates on the Polyplex Transfection Properties, AAPS J. 2009 Sep;11(3):445-55
• Meyer, M., Dohmen, C., Philipp, A., Kiener, D., Maiwald, G., Scheu, C., Ogris, M., Wagner, E. (2009)Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA-Polymer Conjugate, Mol Pharm. 2009 Jun-Jul;6(3):752-62
• Yu, H., Wagner, E. (2009) Bioresponsive polymers for nonviral gene delivery, Curr Opin Mol Ther. 2009 Apr;11(2):165-78
• Cardoso, A.L., Simões, S., de Almeida, L.P., Plesnila, N., Pedroso de Lima, M.C., Wagner, E., Culmsee, C. (2008) Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS, J Control Release. 2008 Dec 8;132(2):113-23.
• Ruß, V., Günther, M., Halama, A., Ogris, M., Wagner, E. (2008) Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery, J Control Release. 2008 Dec 8;132(2):131-40
• Slemmer, J.E., Zhu, C., Landshamer, S., Trabold, R., Grohm, J., Ardeshiri, A., Wagner, E., Sweeney, M.I., Blomgren, K., Culmsee, C., Weber, J.T., Plesnila, N. (2008) Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury, Am J Pathol. 2008 Dec;173(6):1795-805
• Wagner, E. (2008) Ten-year anniversary of Current Opinion in Molecular Therapeutics: A decade of experience in molecular therapeutics - Progress, setbacks and surprises, Curr Opin Mol Ther. 2008 Dec;10(6):544-7
• Wagner, E. (2008) The Silent (R)evolution of Polymeric Nucleic Acid Therapeutics, , Pharm Res. 2008 Dec;25(12):2920-3
• Schwerdt, A., Zintchenko, A., Concia, M., Roesen N., Fisher K., Lindner L.H., Issels R., Wagner, E., Ogris, M. (2008) Hyperthermia induced targeting of thermosensitive gene carriers to tumors, Hum Gene Ther. 2008 Nov;19(11):1283-1292
• Günther, M., Wagner, E., Ogris, M. (2008) Acrolein: unwanted side product or contribution to antiangiogenic properties of metronomic cyclophosphamide therapy? , J. Cell. Mol. Med. 12: 2704-2716
• Philipp, A., Meyer, M., Wagner, E. (2008) Extracellular targeting of synthetic therapeutic nucleic Acid formulations, Curr Gene Ther. 2008 Oct;8(5):324-34
• Landshamer, S., Höhn, M., Barth, N., Duvezin-Caubet, S., Schwake, G., Tobaben, S., Kazhdan, I., Becattini, B., Zahler, S., Vollmar, A., Pellecchia, M., Reichert, A., Plesnila, N., Wagner, E., Culmsee, C. (2008) Bid-induced release of AIF from mitochondria causes immediate neuronal cell death, Cell Death Differ. 2008 Oct;15(10):1553-63
• Schlossbauer, A., Schaffert, D., Kecht, J., Wagner, E., Bein, T. (2008) Click chemistry for high-density biofunctionalization of mesoporous silica, J Am Chem Soc. 2008 Sep 24;130(38):12558-9
• Coulter, J.A., McCarthy, H.O., Xiang, J., Rödl, W., Wagner, E., Robson, T. (2008) Nitric oxide--a novel therapeutic for cancer, Nitric Oxide. 2008 Sep;19(2):192-8
• Schaffert, D., Wagner, E. (2008) Gene therapy progress and prospects: synthetic polymer-based systems, Gene Ther. 2008 Aug;15(16):1131-8
• Knorr, V., Ogris, M., Wagner, E. (2008) An Acid Sensitive Ketal-Based Polyethylene Glycol-Oligoethylenimine Copolymer Mediates Improved Transfection Efficiency at Reduced Toxicity, Pharm Res. 2008 Dec;25(12):2937-45
• Fella, C., Walker, G. F., Ogris, M., Wagner, E. (2008) Amine-reactive pyridylhydrazone-based PEG reagents for pH-reversible PEI polyplex shielding., Eur J Pharm Sci. 2008 Aug;34(4-5):309-20.
• Knorr, V., Ruß, V., Allmendinger L., Ogris, M., Wagner, E. (2008) Acetal Linked Oligoethylenimines for Use As pH-Sensitive Gene Carriers., Bioconjug Chem. 2008 Aug;19(8):1625-34
• Cavallaro G., Scirè S., Licciardi M., Ogris, M., Wagner, E., Giammona G. (2008)Polyhydroxyethylaspartamide-spermine copolymers: Efficient vectors for gene delivery., J Control Release. 2008 Oct 6;131(1):54-63
• Zintchenko, A., Philipp, A., Dehshahri, A., Wagner, E. (2008) Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity, Bioconjug Chem. 2008 Jul;19(7):1448-55
• Vandenbroucke R.E., de Geest, B.G., Bonne, S., Vinken, M., van Haecke, T., Heimberg, H., Wagner, E., Rogiers, V., de Smedt, S., Demeester, J., Sanders, N.N. (2008) Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters), J Gene Med. 2008 Jul;10(7):783-94
• Tietze, N., Pelisek, J., Philipp, A., Rödl, W., Merdan, T., Tarcha, P., Ogris, M., Wagner, E. (2008)Induction of Apoptosis in Murine Neuroblastoma by Systemic Delivery of Transferrin-Shielded siRNA Polyplexes for Downregulation of Ran., Oligonucleotides.2008 Jun;18(2):161-74.
• de Bruin, K.G., Fella, C., Ogris, M., Wagner, E., Ruthardt, N., Bräuchle, C. (2008) Dynamics of photoinduced endosomal release of polyplexes., J Control Release. 2008 Sep 10;130(2):175-82
• DeRouchey, J., Schmidt, C., Walker, G. F., Koch, C., Plank, C., Wagner, E., Rädler, J. O. (2008)Monomolecular Assembly of siRNA and Poly(ethylene glycol)-Peptide Copolymers., Biomacromolecules 9, 724-732
• Meyer, M., Philipp, A., Oskuee, R., Schmidt, C., Wagner, E. (2008) Breathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery., J. Am. Chem. Soc. 130, 3272-3273
• Wagner, E. (2008) Converging paths of viral and non-viral vector engineering., Mol. Ther. 16, 1-2
• Ruß, V., Elfberg, H., Thoma, C., Klöckner, J., Ogris, M., Wagner, E. (2008) Novel degradable oligoethylenimine-acrylate ester-based pseudodendrimers for in vitro and in vivo gene transfer., Gene Ther. 15, 18-29.
• Wagner, E. (2007) Advances in cancer gene therapy: tumor-targeted delivery of therapeutic pDNA, siRNA, and dsRNA nucleic acids., J. BUON 12, S77-S82
• Plesnila, N., von Baumgarten, L., Retiounskaia, M., Engel, D., Ardeshiri, A., Zimmermann, R, Hoffmann, F., Landshamer, S., Wagner, E., Culmsee, C. (2007) Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kB transcriptional activity.Cell Death Differ. 14, 1529-1541
• Gaedtke, L., Thoenes, L., Culmsee, C., Mayer, B., Wagner, E. (2007) Proteomic analysis reveals differences in protein expression in spheroid versus monolayer cultures of low passage colon carcinoma cells.J. Proteome Res. 6, 4111-4118
• Ogris, M., Kotha, A., Tietze, N., Wagner, E., Palumbo, F.S., Giammona, G., Cavallaro, G. (2007) Novel Biocompatible Cationic Copolymers Based on Polyaspartylhydrazide Being Potent as Gene Vector on Tumor Cells.Pharm. Res. 24(12), 2213-2222
• Fahrmeir, J., Günther, M., Tietze, N., Wagner, E., Ogris, M. (2007) Electrophoretic purification of tumor-targeted polyethylenimine-based polyplexes reduces toxic side effects in vivo., J. Control. Rel. 122, 236-245
• Knorr, V., Allmendinger, L., Walker, G. F., Paintner, F. F., Wagner, E. (2007) An acetal based PEGylation reagent for pH-sensitive shielding of DNA polyplexesBioconjug. Chem. 18(4), 1218-1225.
• Ruß, V., Wagner, E. (2007) Cell and tissue targeting of nucleic acids for cancer gene therapyPharm. Res. 24(6), 1047-1057.
• de Bruin, K., Ruthardt, N., von Gersdorff, K., Bausinger, R., Wagner, E., Ogris, M., Braeuchle, C. (2007)Cellular dynamics of EGF receptor-targeted synthetic viruses, Mol. Ther. 15(7), 1297-1305.
• Tarcha, P.J., Pelisek, J., Merdan, T., Waters, J., Cheung, K., von Gersdorff, K., Culmsee, C., Wagner, E. (2007) Synthesis and characterization of chemically condensed oligoethylenimine containing beta-aminopropionamide linkages for siRNA deliveryBiomaterials 28(25), 3731-3740.
• Meyer, M., Zintchenko, A., Ogris, M., Wagner, E. (2007) A dimethylmaleic acid-melittin-polylysine conjugate with reduced toxicity, pH-triggered endosomolytic activity and enhanced gene transfer potential, J. Gene Med. 9(9), 797-805.
• Wagner, E. (2007) Programmed drug delivery: nanosystems for tumor targetingExpert Opin. Biol. Ther. 7(5), 587-593.
• Cardoso, A.L.C., Simoes, S., de Almeida, L.P., Pelisek, J., Culmsee, C., Wagner, E., Pedroso de Lima, M.C. (2007) siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing, J. Gene Med. 9, 170-183.
• Ameri, K., Hammond, E.M., Culmsee, C., Raida, M., Katschinski, D.M., Wenger, R.H., Wagner, E., Davis, R.J., Hai, T., Denko, N., Harris, A.L. (2007) Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway, Oncogene 26, 284-289.
• Gaedtke, L., Pelisek, J., Lipinski, K. S., Wrighton, C. J., Wagner, E. (2007) Transcriptionally targeted nonviral gene transfer using a ß-catenin/TCF-dependent promoter in a series of different human low passage colon cancer cellsMol. Pharmaceutics 4(1), 129-139.
• Boeckle, S., Wagner, E. (2006) Optimizing Targeted Gene Delivery: Chemical Modification of Viral Vectors and Synthesis of Artificial Virus Vector Systems, AAPS J. 8(4), E731-E742.
• Meyer, M., Wagner, E. (2006) Recent Developments in the Application of Plasmid DNA-Based Vectors and Small Interfering RNA Therapeutics for CancerHuman Gene Ther. 17, 1062-1076.
• Culmsee, C., Gasser, E., Hansen, S., Tonn, J.C., Wagner, E., Goldbrunner, R. (2006) Effects of Raf-1 siRNA on human cerebral microvascular endothelial cells: A potential therapeutic strategy for inhibition of tumor angiogenesisBrain Research 1125, 147-154.
• Klöckner, J., Wagner, E., Ogris, M. (2006) Degradable Gene Carriers Based on Oligomerized Polyamines, Eur. J. Pharm. Sci. 29, 414-425.
• Klöckner, J., Boeckle, S., Klöckner, J., Rödl, W., Ogris, M., Berg, K., Wagner, E. (2006) DNA polyplexes based on degradable oligoethylenimine-derivatives: Combination with EGF receptor targeting and endosomal release functions, J. Control. Rel. 116, 115-122.
• Klöckner, J., Bruzzano, S., Ogris, M., Wagner, E. (2006) Gene Carriers Based on Hexanediol Diacrylate-linked Oligoethylenimine: Effect of Chemical Structure of Polymer on Biological Properties, Bioconjug. Chem. 17(5), 1339-1345.
• Meyer, M., Wagner, E. (2006) Bioresponsive shielding of nonviral gene vectors, Expert Opinion on Drug Delivery 3(5), 563-571.
• von Gersdorff, K., Sanders, N.N., Vandenbroucke, R., De Smedt, S.C., Wagner, E., Ogris, M. (2006) The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type, Mol. Ther. 14(5), 745-753.
• DeRouchey, J., Walker, G. F., Wagner, E., Rädler, J.O. (2006) Decorated Rods: A 'Bottom-Up' Self-Assembly of Monomolecular DNA ComplexesJ. Phys. Chem. 110, 4548-4554.
• Günther, M., Waxman, D. J., Wagner, E., Ogris, M. (2006) Effects of Hypoxia and Limited Diffusion in Tumor Cell Microenvironment on Bystander Effect of P450 Prodrug Therapy, Cancer Gene Ther. 13(8), 771-779.
• Prasmickaite, L., Hellum, M., Kaalhus, O., Hogset, A., Wagner, E., Berg, K. (2006) of Transgenes Controlled by the Heat-Shock Protein 70 PromoterPhotochemistry Photobiology 82, 809-816.
• Boeckle, S., Fahrmeir, J., Rödl, W., Ogris, M., Wagner, E. (2006) Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes, J. Control. Rel. 112, 240-248.
• Zintchenko, A., Ogris, M., Wagner, E. (2006) Temperature Dependent Gene Expression Induced by PNIPAM-based Copolymers: Potential of Hyperthermia in Gene Transfer, Bioconjug. Chem. 17(3), 766-772.
• Bausinger, R., von Gersdorff, K., Braeckmans, K., Ogris, M., Wagner, E., Bräuchle, C., Zumbusch, A. (2006) The Transport of Nanosized Gene Carriers Unraveled by Live-Cell Imaging, Angew. Chem. 118, 1598-1602.
• Shir, A., Ogris, M., Wagner, E., Levitzki, A. (2006) EGF Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice, PLoS Med. 3(1), e6.
• Wagner, E., Klöckner, J. (2006) Gene delivery using polymer therapeuticsAdv. Polym. Sci 192, 135-173.
• Pelisek, J., Gaedtke, L., DeRouchey, J., Walker, G. F., Nikol, S., Wagner, E. (2006) Optimized lipopolyplex formulations for gene transfer to human colon carcinoma cells under in vitro conditions, J. Gene Med. 8, 186-197.
• Wagner, E. (2005) Polymer Nonviral Delivery Vehicles, Encyclopedia of Diagnostic Genomics and Proteomics, 1047-1051.
• von Gersdorff, K., Ogris, M., Wagner, E. (2005) Cryoconserved Shielded and EGF Receptor Targeted DNA Polyplexes: Cellular Mechanisms, European Journal of Pharmaceutics and Biopharmaceutics 60, 279-285.
• Walker, G. F., Fella, C., Pelisek, J., Fahrmeir, J., Boeckle, S., Ogris, M., Wagner, E. (2005) Toward synthetic viruses: Endosomal pH triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo, Mol Ther 11(3), 418-425.
• Brabec, M., Schober, D., Wagner, E., Bayer, N., Murphy, R.F., Blaas, D., Fuchs, R. (2005) Opening of size-selective pores in endosomes during human rhinovirus serotype 2 in vivo uncoating monitored by single-organelle flow analysis, J Virol. 79, 1008-16.
• Günther, M., Wagner, E., Ogris, M. (2005) Specific targets in tumor tissue for the delivery of therapeutic genes, Curr Med Chem Anti-Canc Agents 5, 157-171.
• Culmsee, C., Zhu, C., Landshamer, S., Becattini, B., Wagner, E., Pellechia, M., Blomgren, K., Plesnila, N. (2005) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen–Glucose Deprivation and Focal Cerebral IschemiaJ. Neuroscience 25, 10262–10272.
• Zwiorek, K., Klöckner, J., Wagner, E., Coester, C. (2005) Gelatin nanoparticles as a new and simple gene delivery systemJ Pharm Pharm Sci. 7, 22-8.
• Couvreur, P., Braguer, D., Crommelin, D.J.A., Duchene, D., Engels, J.W., Kerr, D.J., Krogsgaard-Larsen, P., Meijer, D.K., Paoletti, R., Wagner, E. (2005) Contribution of academic research to discovery and development of medicines: current status and future opportunitiesEur J Pharm Sci 24, 245-252.
• Boeckle, S., Wagner, E., Ogris, M. (2005) C- versus N-terminally linked melittin-polyethylenimine conjugates: the site of linkage strongly influences activity of DNA polyplexes, J. Gene Med. 7, 1335-1347.
• Magin-Lachmann, C., Kotzamanis, G., DAiuto, L., Cooke, H., Huxley, C., Wagner, E. (2004) In vitro and in vivo delivery of intact BAC DNA – comparison of different methods, J. Gene Med. 6, 195-209.
• Wagner, E. (2004) Strategies to improve DNA polyplexes for in vivo gene transfer – will “artificial viruses†be the answer? Pharm, Res. 21(1), 8-14.
• Klöckner, J., Prasmickaite, L., Hogset, A., Berg, K., Wagner, E. (2004) Photochemically enhanced gene delivery of EGF receptor-targeted DNA polyplexes, Journal of Drug Targeting 12 (4), 205-213.
• Wagner, E., Kircheis, R., Walker, G. F. (2004) Targeted nucleic acid delivery into tumors: new avenues for cancer therapy, Biomedicine & Pharmacotherapy 58, 152-161.
• Lenter, M. C., Garidel P., Pelisek, J., Wagner, E., Ogris, M. (2004) Stabilized non-viral formulations for the delivery of MCP-1 gene into cells of the vasculoendothelial system, Pharm. Res. 21(4), 683-691.
• Pelisek, J., Kühnl, A., Rolland, P.H., Mekkaoui, C., Fuchs, A., Walker, G. F., Ogris, M., Wagner, E., Nikol, S. (2004) Functional analysis of genomic DNA, cDNA and nucleotide sequence of the mature C-type natriuretic peptide gene in vascular cells, Arteriosclerosis, Thrombosis, Vascular Biol. 24, 1646-1651.
• Boeckle, S., von Gersdorff, K., van der Piepen, S., Culmsee, C., Wagner, E., Ogris, M. (2004) Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer, J. Gene Med. 6, 1102-1111.
• Hildebrandt, I.J., Iyer, M., Wagner, E., Gambhir, S.S. (2003) Optical Imaging of Transferrin Targeted PEI/DNA Complexes in Living Subjects, Gene Ther. 10, 758-764.
• Gharwan, H., Wightman, L., Kircheis, R., Wagner, E., Zatloukal, K. (2003) Nonviral gene transfer into fetal mouse livers, Gene Ther. 10, 810-817.
• Smrekar B., Wightman L., Wolschek M.F., Lichtenberger, C., Ruzicka, R., Ogris, M., Rödl, W., Kursa, M., Wagner, E., Kircheis, R. (2003) Tissue-dependent factors affect gene delivery to tumors in vivo, Gene Ther. 10, 1079-1088.
• Kircheis, R., Wagner, E. (2003) Technology evaluation: TNFerade, Gen VecCurr. Opin. Mol. Ther. 5(4), 437-447.
• Magin-Lachmann, C., Kotzamanis, G., DAiuto, L., Wagner, E., Huxley, C. (2003) Retrofitting BACs with G418 resistance, luciferase, and oriP and EBNA-1 new vectors for in vitro and in vivo deliveryBioMedCentral Biotechnology 3:2.
• Ogris, M., Walker, G. F., Blessing, T., Kircheis, R., Wolschek, M., Wagner, E. (2003) Tumor-Targeted Gene Therapy: Strategies for Preparation of Ligand-Polyethylene Glycol-Polyethylenimine / DNA Complexes., J. Controlled Rel. 91, 173-181.
• Kursa, M., Walker, G. F., Roessler, V., Ogris, M., Rödl, W., Kircheis, R., Wagner, E. (2003) Novel shielded Transferrin-Polyethylene Glycol-Polyethylenimine / DNA Complexes for Systemic Tumor-Targeted Gene Transfer, Bioconjug. Chem. 14, 222-231.
• Dätwyler, D.A., Magyar, J.P., Weikert, C., Wightman, L., Wagner, E., Eppenberger, H.M. (2003) Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytesCell Tissues Organs 175, 61-71.
• Kircheis, R., Kursa, M., Wightman, L., Wagner, E. (2002) Transferrinfection for efficient gene transfer to tumor cells, BenderMedSystems, 2-7.
• Kircheis, R., Ostermann, E., Wolschek, M.F., Lichtenberger, C., Magin-Lachmann, C., Wightman, L., Kursa, M., Wagner, E. (2002) Tumor-targeted gene delivery of tumor necrosis factor-alpha induces tumor necrosis and tumor regression without systemic toxicityCancer Gene Ther., 9, 673-680.
• Wagner, E., Culver, K.W., Jones, D. (2002) Molecular therapeutics beyond the genome sequencing era, Curr. Opin. Mol. Ther. 4 (1), i-ii (editorial).
• Ogris, M., Wagner, E. (2002) Tumor-targeted Gene Transfer with DNA Polyplexes., Somatic Cell and Molecular Genetics 27(1-6), 85-95.
• Brunner, S., Fürtbauer, E., Sauer, T., Kursa, M., Wagner, E. (2002) Overcoming the nuclear barrier: cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation, Mol. Ther. 5(1), 80-85
• Ogris, M., Wagner, E. (2002) Targeting tumors with non-viral gene delivery systems., Drug Discovery Today 7 (8), 479-485.
• Kircheis, R., Ostermann, E., Kursa, M., Wightman, L., Wagner, E. (2001) Tumor-targeted gene delivery: an attractive strategy to use highly active effector molecules in cancer treatment, Gene Ther. 9, 731-735.
• Vécsey-Semjen, B., Becker, K.-F., Sinski, A., Blennow, E., Vietor, I., Zatloukal, K., Beug, H., Wagner, E., Huber, L.A. (2001) Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers, Oncogene, 21, 4646-4662
• Wolschek, M.F., Thallinger, C., Kursa, M., Rössler, V., Allen, M., Lichtenberger, C., Kircheis, R., Lucas, T., Willheim, M., Reinisch, W., Gangl, A., Wagner, E., Jansen, B. (2001) Specific systemic non-viral gene delivery to human hepatocellular carcinoma xenografts in SCID miceHepatology 36, 1106-1114.
• Kircheis, R., Wightman, L., Schreiber, A., Robitza, B., Rössler, V., Kursa, M., Wagner, E. (2001)Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application, Gene Therapy 8, 28-40.
• Düchler, M., Pengg, M., Brunner, S., Müller, M., Brem, G., Wagner, E. (2001) Transfection of epithelial cells is enhanced by combined treatment with mannitol and polyethyleneglycolJ. Gene Medicine 3, 115-124.
• van Slooten, M.L., Hayon, I., Babai, I., Zakay-Rones, Z., Wagner, E., Storm, G., Kedar, E. (2001) Immunoadjuvant activity of interferon-gamma-liposomes co-administered with influenza vaccinesBiochim. Biophys. Acta 1531, 99-110.
• Kircheis, R., Blessing, T., Wightman, L., Brunner, S., Wagner, E. (2001) Tumor targeting with surface-shielded ligand-polycation DNA complexesJ. Controlled Rel. 72, 165-170.
• Kircheis, R., Wightman, L., Wagner, E. (2001) Design and gene delivery activity of modified polyethyleniminesAdv. Drug Del. Rev. 53, 341-358
• Blessing, T., Kursa, M., Holzhauser, R., Kircheis, R., Wagner, E. (2001) Different Strategies for Formation of PEGylated EGF-conjugated PEI/DNA Complexes for Targeted Gene DeliveryBioconjug. Chem. 12, 529-537.
• Wightman, L., Kircheis, R., Rössler, V., Carotta, S., Ruzicka, R., Kursa, M., Wagner, E. (2001) Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivoJ. Gene Medicine 3, 362-372.
• Felzmann, T., Buchberger, M., Lehner, M., Printz, D., Kircheis, R., Wagner, E., Gadner, H., Holter, W. (2001) Functional maturation of dendritic cells by exposure to CD40L transgenic tumor cells or primary fibroblasts and keratinocytesCancer Letters 168, 145-154.
• Kircheis, R., Wightman, L., Kursa, M., Smrekar, B., Ostermann, E., Wagner, E. (2001) Surface-shielded polycation-based systems targeting reporter and therapeutic genes to distant tumorsGene Ther. Mol. Biol. 6, 159-167.

• Ogris, M., Steinlein, P., Carotta, S., Brunner, S., and Wagner E. (2001) DNA/polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalisation and gene expression. AAPS PharmSci, 3(3) article 21

• Wagner, E., Ameri, K. (2000) Receptor mediated gene transfer. Chapter 8 in “Gene Therapy. Therapeutic Mechanisms and Strategies”, N. Smyth-Templeton, D.Lasic (Eds), Marcel Dekker Inc, New York, p 141-164.
• Kircheis, R., Kursa, M., Wightman, L., Brunner, S., Ogris, M., Schüller, S., and Wagner, E. (2000) Systemic in vivo gene delivery into tumors by the use of transferrin-polyethylenimine DNA complexes. NATO Science Series, A: Life Sciences, 323, 186-191.
• Kircheis, R., and Wagner, E. (2000) Polycation/DNA complexes for in vivo gene delivery. Gene Therapy and Regulation 1, 95-114.
• Kircheis, R., Wightman, L., Ogris, M., Brunner, S., Kursa, M., Schüller, S., and Wagner, E. (2000) Receptor -mediated gene transfer based on plasmid DNA complexes. Chapter in: Gene Therapy, Bertolotti, Ed.
• Brunner, S., Sauer, T., Carotta, S., Cotten, M., Saltik, M., and Wagner, E. (2000) Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus. Gene Therapy 7, 401-407.
• van Slooten, M.L., Storm, G., Zoephel, A., Küpcü, Z., Boerman, O., Crommelin, D.J.A., Wagner, E., Kircheis, R. (2000) Liposomes containing interferon-gamma as adjuvant in tumor cell vaccines. Pharm. Res. 17, 42-48.
• Ogris, M., Wagner, E., and Steinlein, P. (2000) A versatile assay to study cellular uptake of gene transfer complexes by flow cytometry. Biophys. Biochim. Acta 1474, 237-43.
• Huber, M., Limat, A., Wagner, E., and Hohl, D. (2000) Efficient in vitro transfection of human keratinocytes with an adenovirus-enhanced receptor-mediated system. J. Invest. Dermatol. 114, 661-666.
• Kircheis, R., Küpcü, Z., Wallner, G., Rössler, V., Schweighoffer, T., and Wagner, E. (2000) IL-2 gene-modified allogeneic melanoma cell vaccines can induce cross-protection against syngeneic tumor challenge in mice. Cancer Gene Therapy 7, 870-878.
• Felzmann, T., Buchberger, M., Jechlinger, M., Kircheis, R., Wagner, E., and Gadner, H. (2000) Xenogenization by tetanus toxoid loading into lymphoblastoid cell lines and primary human tumor cells mediated by polycations and liposomes. Cancer Letters 161, 241-250