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Dr. Aditi Mehta

Dr. Aditi Mehta (Postdoc)

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Since September 2020 Senior Manager Drug Delivery, Merck KGaA

November 2017 - August 2020 Group Leader, LMU Munich
March 2016 - November 2017 Postdoc, LMU Munich
2015 Postdoc Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
2015 PhD, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
2009 MS in Genetics, University of Delhi, India
2007 BS in Microbiology, University of Delhi, India

Publications:

A Method for Targeted Nonviral siRNA Delivery in Cancer and Inflammatory Diseases. Kandil R, Xie Y, Mehta A, Merkel O.
Methods Mol Biol. 2020;2059:155-166.

Aditi Mehta, Olivia M. Merkel*: Immunogenicity of Cas9 Protein.
Journal of Pharmaceutical Sicences 2020, 109 (1), 62-67.

Coming in and Finding Out: Blending Receptor-Targeted Delivery and Efficient Endosomal Escape in a Novel Bio-Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells. Kandil R, Xie Y, Heermann R, Isert L, Jung K, Mehta A, Merkel OM.
Adv Ther (Weinh). 2019 Jul;2(7). pii: 1900047.

Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles. Mehta A, Dalle Vedove E, Isert L, Merkel OM.
Pharm Res. 2019; 36 (9): 133.

Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, Mehta A, Wujak L, Cabrera-Fuentes H, Chao CM, Braubach P, Bellusci S, Seeger W, Günther A, Preissner KT, Wygrecka M, Savai R, Papy-Garcia D, Dobreva G, Heikenwalder M, Savai-Pullamsetti S, Braun T, Barreto G.
Nat Commun. 2019; 10 (1): 2229.

CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review. Babačić H, Mehta A, Merkel O, Schoser B.
PLoS One. 2019; 14 (2): e0212198.

MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization. Singh I, Contreras A, Cordero J, Rubio K, Dobersch S, Günther S, Jeratsch S, Mehta A, Krüger M, Graumann J, Seeger W, Dobreva G, Braun T and Barreto G. MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolus organization.
Nat Genet 2018; 50 (7): 990-1001

Non-invasive approaches for lung cancer diagnosis. Mehta A, Barreto G.
Indian J Thorac Cardiovasc Surg (2018) 34(Suppl 1): 11.

Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate., Mehta A, Cordero J, Dobersch S, Romero-Olmedo AJ, Savai R, Bodner J, Chao CM, Fink L, Guzmán-Díaz E, Singh I, Dobreva G, Rapp UR, Günther S, Ilinskaya ON, Bellusci S, Dammann RH, Braun T, Seeger W, Gattenlöhner S, Tresch A, Günther A, Barreto G., EMBO Mol Med. 2016; 8 (12):1380-1389.

High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX., Singh I, Ozturk N, Cordero J, Mehta A, Hasan D, Cosentino C, Sebastian C, Krüger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R, Barreto G., Cell Res. 2015; 25 (7):837-50.

Epigenetics in lung cancer diagnosis and therapy., Mehta A, Dobersch S, Romero-Olmedo AJ, Barreto G., Cancer Metastasis Rev. 2015; 34 (2):229-41.

Validation of Tuba1a as appropriate internal control for normalization of gene expression analysis during mouse lung development., Mehta A, Dobersch S, Dammann RH, Bellusci S, Ilinskaya ON, Braun T, Barreto G., Int J Mol Sci. 2015; 16 (3):4492-511

HMGA proteins as modulators of chromatin structure during transcriptional activation., Ozturk N, Singh I, Mehta A, Braun T, Barreto G., Front Cell Dev Biol. 2014; 2:5.

Hmga2 is required for canonical WNT signaling during lung development., Singh I, Mehta A, Contreras A, Boettger T, Carraro G, Wheeler M, Cabrera-Fuentes HA, Bellusci S, Seeger W, Braun T, Barreto G., BMC Biol. 2014; 12:21.

Quantitative proteome analysis of alveolar type-II cells reveals a connection of integrin receptor subunits beta 2/6 and WNT signaling., Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M, Barreto G., J Proteome Res. 2013; 12 (12):5598-608.