Protein post-translational modifications (PTMs) create a complex regulatory layer of proteins’ activity providing the cell with mechanisms to swiftly adjust its metabolism to changing environment, and hence keep the cell homeostasis. Central processes modulating neurodevelopment and neurodegeneration are controlled by protein PTMs. Our objectives are to map and functionally characterize protein PTMs to better understand the fundamental regulatory pathways behind neurodevelopment and to identify PTM-based markers for early diagnosis of neurodegenerative diseases. We aim to develop creative chemical biology tools, chemical proteomic methods and mass spectrometry techniques for characterization of protein PTMs in neurological disorders.
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