Kielkowski Research Group - Faculty for Chemistry and Pharmacy

News

09.09.2022 Andreas Wiest was just granted the PhD felloship from Studienstiftung. Congratulation! We are curious about your next experiemnts and progress in your project and thank the Studienstiftung for the support!

04.07.2022 Congratulation Dmytro! The manuscript on protein tyrosination is now available on preprint biorxiv. This is our first step towards tubulin post-translational modification chemical biology tools.

01.07.2022 The mass spectrometry-based chemical proteomics SP2E workflow is now out in JACS Au. The Article has two parts: 1) development of the SP2E methodology in large scale and smale scale (96-well plate format) and 2) identification of novel AMPylation targets including amyloid precursor protein (APP) and O-Glycosylation profiling.

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23.06.2022 Indeed, we could not miss the visit to analytica 2022. The liquid handeling robots were in our visire.

20.06.2022 Daniel Bjeko has joined the group for his master thesis research. Welcome! Daniel is already the coauthor on the SP2E publication. Now, he will further dive into proteomic techniques for protein PTMs analysis.

11.06.2022 This time Dmytro joined Pavel at EMBL Symposium: Microtubules: From atoms to complex systems! Both posters presenting SP2E workflow and chemical proteomic strategy to profile tubulin tyrosination draw a lot of attention. Indeed, as common for EMBL Symposia, great science and fantastic evening program. We are more than motivated to move on with the projects.

02.06.2022 Tobias and Pavel represented the group at Next-Generation Protein Analysis and Detection conference in Ghent (Belgium). It was great to get an overview of the most recent mass spectrometry techniques and software tools.

25.05.2022 The Collaborative Research Center - SFB1309 "Chemical Biology of Epigenetic Modifications" from DFG has been successfully extended including now as well our four years project on protein PTMs! Thanks to the speaker Thomas Carell for organization. Looking forward to many exciting collaborations.

04.04.2022 After a short break we welcome Andreas Wiest in our group again, this time starting his PhD. He is going to explore the tubulin code PTMs using the mass spectrometry and chemical proteomics. We wish you all the best!

24.03.2022 It was great to present our research on role of protein PTMs in neurodevelopment in Ascona (Switzerland) during woderful meeting: Neurogenesis from development to adulthood in health and disease. Thanks to Fiona Doetsch, Denis Jabaudon, Sebastian Jessberger and Marlen Knobloch for the fatntastic organisation.

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17.03.2022 Andreas Wiest has just succesffully finished his master thesis on tubulin code deconvolution, which opened completely new avenues for tubulin research and beyond. Stay tuned! Looking forward to welcome him soon for PhD.

14.02.2022 Congratulation to Dmytro Makarov and András Telek to their publication on "Clickable report tags for identification of modified peptides by mass spectrometry". Thank to our collaborators from Sabine Schneider group at ICEM!

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25.01.2022 Our optimised mass spectrometry-based chemical proteomic SP2E workflow for analysis of protein PTMs is now on bioRxiv. Suitable for low protein input and 96-well plate format. Easy, robust and fast. Thanks to Tobias and all coauthors for their contribution to workflow optimisations!

18.01.2022 Congratulation to Dmytro and András to their new publication on clickable reporter tag! Thanks Schneider's group for the great collaboration within SFB1309.

09.12.2021 The exciting story of PLD3 AMPylation is now out. Big congratulation to Tobias and thanks to all collaborators! Have a look at iScience.

02.11.2021 Excited that the story about the LGALS3BP and its importance for generation of basal progenitors is out in Nature Communications. The work has been done by Christina Kyrousi in Silvia Cappello's lab at MPI of Psychiatry. Pavel has contributed to this article by mass spectrometry-based proteomics as a post-doc at TUM with Stephan Sieber. Congratulation to all authors!

25.10.2021 We are now up and runnig in the new building - ICEM!

15.10.2021 It was a pleasure to present our recently developed SP2E chemical proteomic method on mass spectrometry conference in Prague.

13.09.2021 Welcome Trinh in our group! He will work on his bachelor thesis synthetizing new PTM analogues.

01.09.2021 Paul Weiß from Georg August University Göttingen join the group for his master thesis. Welcome and all the best!

30.07.2021 We wish all the best to András Telek in pursuing his PhD in joint academia and industry settings in Budapest! It was great to have you in the group and diving into fragmentation properties of protein PTMs.

19.07.2021 Great to have Kristina Kostadinova from UCL as the summer school student in our group.

03.06.2021 Congratulation Haoyu for being awarded the Chinese Government Scholarship for his stay at LMU!

10.05.2021 I am glad to welcome Andreas Wiest in our group! In his master thesis he will focus on analysis of specific protein PTMs in neurons.

23.03.2021 LMUexcellent will generously support our research through Junior Research Fund.

03.03.2021 Very happy to share our latest findings on AMPylation of the lysosomal protein PLD3 and its connection to neuronal differentiation. Now available on bioRxiv here.

01.02.2021 We are glad to have András back on the board after his F-praktikum in our lab, now for his master thesis.

22.12.2020 May the Mass be with you in 2021!

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07.12.2020 Welcome Haoyu! He is staring his PhD in the group, working on new approaches for protein PTM analysis.

20.11.2020 Thanks to Tobias for preparing the article for BIOspektrum and Stephan Sieber's lab for supporting this project. It is now online!

27.10.2020 Lisa has just very succesfullly finished her Master thesis and is leaving for her PhD to the group of Prof. Andreas Marx at University of Konstanz. All the best for her.

12.10.2020 Welcome Alex! He has just started his bachelor thesis in our group.

05.10.2020 Tobias was awarded the Jürgen Manchot prize at TUM for his outstanding master degree in biochemistry. Great to have you on board!

14.09.2020 Welcome Dmitrij! He is starting his PhD fully focused on development of new chemical biology tools for analysis of PTMs role in neurological disorders.

17.08.2020 We are glad to have Martina in our group. She is working on her bachelor thesis.

16.07.2020 The Cover design of our Perspective is now online.

09.06.2020 Check out our Perspective on protein AMPylation: From Young to Old: AMPylation Hits the Brain.

18.05.2020 We are happy to be associated with the SFB1309, Collaborative Research Center on "Chemical Biology of Epigenetic Modifications".

05.03.2020 Congratulation Tobias for receiving the Liebig PhD fellowship from FCI!!

02.03.2020 Welcome Lisa! She will do her master thesis in our group.

29.11.2019 Liebig Fellowship from FCI was awarded to Pavel!

04.11.2019 Tobias is starting his PhD. Welcome!

04.11.2019 Now.

20.10.2019 Kielkowski group is starting in November 2019.