Start page

According to log k_20°C = s_N(N + E)

Currently the database contains the reactivity parameters of 1243 nucleophiles and 344 electrophiles.

News: Electrophilicities of diazo compounds in azo couplings (ChemEurJ, doi: 10.1002/chem.202201376)

Covered nucleophilicity range: -8.80 ≤ N ≤ 30.82
Covered electrophilicity range: -29.60 ≤ E ≤ 8.02

• Nucleophiles (1251)
• C-Nucleophiles (531)
• Alkenes (57)
• Mono-enes (44)
• 1,3-Dienes (13)
• Alkyl and Aryl Boron Compounds (37)
• Alkylating Boron Compounds (10)
• Arylating Boron Compounds (27)
• Alkynes (1)
• Allyl Element Compounds (38)
• Allyl-B (5)
• Allyl-Si (21)
• Allyl-Sn, Ge, Zn or Fe (12)
• Arenes (42)
• Carbocyclic Arenes (6)
• Indoles (18)
• Pyrroles (7)
• Other Heterocyclic Arenes (11)
• Azolium enolates (4)
• Breslow intermediates (11)
• Desoxy-Breslow intermediates (7)
• O-Methylated Breslow intermediates (4)
• Carbanions (152)
• Carbanions in DMSO (116)
• Carbanions in water (17)
• Carbanions in other solvents (19)
• Carbenes (NHCs) (7)
• Enol Ethers (51)
• C=C-OR (4)
• C=C-OSi (34)
• C=C(OR)₂ (1)
• C=C(OR)(OSi) (12)
• Enamines, NHOs, Enamides and Ynamides (65)
• Diazo Compounds and Hydrazones (13)
• Isonitriles (5)
• Metal-π-Complexes (5)
• Metallocenes (6)
• Vinylsilanes (7)
• Ylides (30)
• Iodonium Ylides (4)
• N-Ylides (9)
• P-Ylides (7)
• S-Ylides (10)
• H-Nucleophiles (191)
• H-B hydride donors (23)
• H-C hydride donors (98)
• H-Si hydride donors (39)
• H-Sn and H-Ge hydride donors (5)
• H-P hydride donors (6)
• transition metal hydride donors (20)
• Halide Anions (29)
• O-Nucleophiles (138)
• Alkoxide Anions (11)
• Amide Anions (O reactivity)
• Alcohols and aqueous solvents (57)
• Ethanol-Acetonitrile mixtures (8)
• Methanol-Acetonitrile mixtures (8)
• Other solvents (pure or mixtures) (11)
• Water-Acetonitrile mixtures (8)
• Water-Ethanol mixtures (7)
• Water-HFIP mixtures (8)
• Water-Trifluoroethanol mixtures (7)
• Carboxylates and Carbonates (11)
• Other O-centered nucleophiles (5)
• Peroxy anions (16)
• Phenolate Ions (38)
• N-Nucleophiles (311)
• Aliphatic amines (104)
• Aromatic amines (7)
• Amide anions (N reactivity) (21)
• Amidines and Imines (10)
• Amino acids (20)
• Azoles and Azole Anions (33)
• Guanidines (8)
• Hydrazines, Hydroxylamines etc. (21)
• Imidazolines and related compounds (10)
• Isothioureas (11)
• Nucleobases and Their Subunits (15)
• Pyridines, Quinolines etc. (41)
• Other N-centered nucleophiles (10)
• S- and Se-Nucleophiles (33)
• P-Nucleophiles (18)