Mayr's Database of Reactivity Parameters

trifluoroethanol

For reactivities of structurally related compounds go to: Nucleophiles » O-Nucleophiles » Alcohols and aqueous solvents » Other solvents (pure or mixtures)

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Name trifluoroethanol
Structure
image of molecule
Molecule class Nucleophiles » O-Nucleophiles » Alcohols and aqueous solvents » Other solvents (pure or mixtures)
SMILES [H]OCC(F)(F)F
Molecular formula C2H3F3O
Quality ***
Parameters

N  Param.: 1.11

sN Param.: 0.96
Comment

Solvent nucleophilicity parameters N and sN were determined with reference electrophiles and correspond to first-order rate constants. Previously published reactivity parameters have been revised (N = 1.23, sN = 0.92, J. Am. Chem. Soc. 2004, 126, 5174-5178).
Solvent TFE
Reference J. Am. Chem. Soc. 2012, 134, 13902-13911
10.1021/ja306522b