Search
| Name | Solvent |
Reactivity Parameters |
Classification |
Reference (title or year) |
|---|---|---|---|---|
pentan-2-one (in DMSO)  |
DMSO | E Param.: -22.30 |  | J. Am. Chem. Soc. 2018, 140, 5500-5515 10.1021/jacs.8b01657 |
1-methylsulfanylpropan-2-one (in DMSO) |
DMSO | E Param.: -15.60 | | J. Am. Chem. Soc. 2018, 140, 5500-5515 10.1021/jacs.8b01657 |
N-methyl-N-((trifluoromethyl)thio)-aniline |
E Param.: -23.32 | | Angew. Chem. Int. Ed. 2018, 57, 12690-12695 10.1002/anie.201805859 | |
1-(benzylideneamino)-2-ethoxy-2-oxoethan-1-ide (in DMSO) |
DMSO | N Param.: 29.10 sN Param.: 0.50 | | Tetrahedron 2019, 75, 459-463 10.1016/j.tet.2018.1[...] |
cyano((diphenylmethylene)amino)methanide |
DMSO | N Param.: 29.50 sN Param.: 0.50 | | Tetrahedron 2019, 75, 459-463 10.1016/j.tet.2018.1[...] |
3-methylcyclopentenone |
DMSO | E Param.: -28.90 | | Chem. Sci. 2021, 12, 4850-4865 10.1039/D0SC06628A |
m-(trifluoromethyl)phenolate (in MeCN) |
MeCN | N Param.: 23.20 sN Param.: 0.51 | | J. Org. Chem. 2019, 84, 8837-8858 10.1021/acs.joc.9b01485 |
m-(trifluoromethyl)phenolate (in DMF) |
DMF | N Param.: 23.40 sN Param.: 0.51 | | J. Org. Chem. 2019, 84, 8837-8858 10.1021/acs.joc.9b01485 |
2-methylcyclohexenone |
DMSO | E Param.: -27.50 | | Chem. Sci. 2021, 12, 4850-4865 10.1039/D0SC06628A |
3-methylcyclohexenone |
DMSO | E Param.: -29.60 | | Chem. Sci. 2021, 12, 4850-4865 10.1039/D0SC06628A |
(Z)-but-2-ene |
dichloromethane | N Param.: -2.44 sN Param.: 1.09 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
(triisopropylsiloxy)ethene |
dichloromethane | N Param.: 3.44 sN Param.: 0.94 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
(2-methylallyl)triphenylsilane |
dichloromethane | N Param.: 4.17 sN Param.: 0.79 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
2-(triisopropylsiloxy)propene |
dichloromethane | N Param.: 5.38 sN Param.: 0.85 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
N-vinylcarbazole |
dichloromethane | N Param.: 5.02 sN Param.: 0.94 | | Macromolecules 2002, 35, 5454-5458 10.1021/ma020306l |
diethyl diazomalonate |
dichloromethane | N Param.: -0.35 sN Param.: 0.93 | | Chem. Eur. J. 2003, 9, 4068-4076 10.1002/chem.200304913 |
3,3-dimethyl-2-(trimethylsiloxy)buten |
dichloromethane | N Param.: 3.78 sN Param.: 0.79 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
chloride (in MeCN) |
MeCN | N Param.: 17.20 sN Param.: 0.60 | | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n |
4-cyanophenyl isocyanide |
dichloromethane | N Param.: 3.57 sN Param.: 0.72 | | Angew. Chem. Int. Ed. 2007, 46, 3563-3566 10.1002/anie.200605205 |
bh6a |
E Param.: -18.60 | | Chem. Eur. J. 2010, 16, 1365-1371 10.1002/chem.200902487 |
News
- 01/30/25:
Sesamol-derived ortho-quinone methides (o-QM) have been added (ChemEurJ 2024, e202403785 & OBC 2025, 23, 827-834) - 05/22/24:
Lactone enolates have been added (JOC 2024, 89, 6915-6928). - 11/13/24:
2-Methylene-1,2-dihydropyridines (2-pyNHOs) have been added (EurJOC 2024, 27, e202400373). - 05/21/24:
Mesoionic pyridinium-derived N-heterocyclic olefins (py-mNHOs) have been added (Angew. Chem. Int. Ed. 2024, 63, e202318283). - 10/19/23:
Enamines derived from 4-(alkylthio)-3-imidazolines and aldehydes have been added (ChemEurJ 2023, doi: 10.1002/chem.202302764). - 09/28/23:
Mesoionic N-heterocyclic olefins (mNHOs) have been added (Angew. Chem. Int. Ed. 2023, 62, e202309790). - 07/05/23:
S-Cyanomethylated imidazolidine-4-thione-derived enamines have been added (ChemComm 2023, 59, 8091). - 03/16/23:
Cyclic alpha-diazo carbonyl compounds added (EurJOC 2023, 26, e202300005) - 01/30/23:
NADH and NADPH reactivities (in water, pH 7) determined by Mayer and Moran have been added (OBC 2022, 21, 85-88). - 09/20/22:
Alkenyl boronate nucleophilicity by Liu, Ready and co-workers has been added (JACS 2022, 144, 16118). - 01/30/23:
Electrophilicities of diazo compounds in azo couplings (ChemEurJ 2022, 28, e202201376) - 01/30/23:
Diazocyclopentadiene added (Synthesis 2023, 55, 354-358) - 01/30/23:
Electrophilic indoles added (ChemCommun 2021, 57, 10071-10074) - 04/13/21:
Cyclic Michael acceptors added (Chem. Sci. 2021, 12, 4850-4865) - 05/21/21:
Thiophenolates (in DMSO) added (JOC 2021, 86, 5965-5972) - 05/06/20:
Heteroallenes added (JACS 2020, 142, 8383-8402). - 01/27/20:
Pyrrolidines and Imidazolidinones added (JACS 2020, 142, 1526-1547). - 05/06/20:
GSH reactivity added (Angew. Chem. Int. Ed. 2019, 58, 17704-17708) - 01/30/23:
Phenolates added (JOC 2019, 84, 8837-8858) - 04/24/18:
Ketones added (JACS 2018, 140, 5500). - 11/03/17:
Allyl-boron nucleophiles added (JACS 2017, 139, 15324) - 04/23/18:
Peroxide anions added (Angew. Chem. Int. Ed. 2017, 56, 13279). - 04/23/18:
Michael acceptors added (JACS 2017, 139, 13318). - 06/16/17:
Nucleophilicities of VNS reagents (JOC 2017, 82, 1011).