Search
| Name | Solvent |
Reactivity Parameters |
Classification |
Reference (title or year) |
|---|---|---|---|---|
pyridin-4-yl((4-(trifluoromethyl)phenyl)sulfonyl)amide (Ph4P+) (in MeCN)  |
MeCN | N Param.: 19.51 sN Param.: 0.47 |  | J. Org. Chem. 2025, 90, 2298-2306 10.1021/acs.joc.4c02668 |
pyridin-4-yl(tosyl)amide (Ph4P+) (in MeCN) |
MeCN | N Param.: 17.19 sN Param.: 0.64 | | J. Org. Chem. 2025, 90, 2298-2306 10.1021/acs.joc.4c02668 |
pyridin-4-yl((trifluoromethyl)sulfonyl)amide (Bu4P+) (in MeCN) |
MeCN | N Param.: 16.48 sN Param.: 0.60 | | J. Org. Chem. 2025, 90, 2298-2306 10.1021/acs.joc.4c02668 |
pyridin-4-yl((trifluoromethyl)sulfonyl)amide (Bu4N+) (in MeCN) |
MeCN | N Param.: 16.68 sN Param.: 0.59 | | J. Org. Chem. 2025, 90, 2298-2306 10.1021/acs.joc.4c02668 |
50% water/50% MeCN (v/v) |
water-MeCN mix | N Param.: 5.05 sN Param.: 0.89 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
2,6-di-tert-butyl-4-methylenecyclohexa-2,5-dien-1-one |
E Param.: -11.17 | | Chem. Eur. J. 2025, , EarlyView 10.1002/chem.202501224 | |
2,6-di-tert-butyl-4-(methoxymethylene)cyclohexa-2,5-dien-1-one |
E Param.: -15.10 | | Chem. Eur. J. 2025, , EarlyView 10.1002/chem.202501224 | |
2-(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)acetonitrile |
E Param.: -11.88 | | Chem. Eur. J. 2025, , EarlyView 10.1002/chem.202501224 | |
ethyl 2-(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)acetate |
E Param.: -12.01 | | Chem. Eur. J. 2025, , EarlyView 10.1002/chem.202501224 | |
2,6-di-tert-butyl-4-ethylidenecyclohexa-2,5-dien-1-one |
E Param.: -13.68 | | Chem. Eur. J. 2025, , EarlyView 10.1002/chem.202501224 | |
4-benzylidene-2,6-di-tert-butylcyclohexa-2,5-dien-1-one |
E Param.: -15.58 | | Chem. Eur. J. 2025, , EarlyView 10.1002/chem.202501224 | |
(Z)-but-2-ene |
dichloromethane | N Param.: -2.44 sN Param.: 1.09 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
(triisopropylsiloxy)ethene |
dichloromethane | N Param.: 3.44 sN Param.: 0.94 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
(2-methylallyl)triphenylsilane |
dichloromethane | N Param.: 4.17 sN Param.: 0.79 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
2-(triisopropylsiloxy)propene |
dichloromethane | N Param.: 5.38 sN Param.: 0.85 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
N-vinylcarbazole |
dichloromethane | N Param.: 5.02 sN Param.: 0.94 | | Macromolecules 2002, 35, 5454-5458 10.1021/ma020306l |
diethyl diazomalonate |
dichloromethane | N Param.: -0.35 sN Param.: 0.93 | | Chem. Eur. J. 2003, 9, 4068-4076 10.1002/chem.200304913 |
3,3-dimethyl-2-(trimethylsiloxy)buten |
dichloromethane | N Param.: 3.78 sN Param.: 0.79 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y |
chloride (in MeCN) |
MeCN | N Param.: 17.20 sN Param.: 0.60 | | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n |
4-cyanophenyl isocyanide |
dichloromethane | N Param.: 3.57 sN Param.: 0.72 | | Angew. Chem. Int. Ed. 2007, 46, 3563-3566 10.1002/anie.200605205 |
News
- 01/30/25:
Sesamol-derived ortho-quinone methides (o-QM) have been added (ChemEurJ 2024, e202403785 & OBC 2025, 23, 827-834) - 05/22/24:
Lactone enolates have been added (JOC 2024, 89, 6915-6928). - 11/13/24:
2-Methylene-1,2-dihydropyridines (2-pyNHOs) have been added (EurJOC 2024, 27, e202400373). - 05/21/24:
Mesoionic pyridinium-derived N-heterocyclic olefins (py-mNHOs) have been added (Angew. Chem. Int. Ed. 2024, 63, e202318283). - 10/19/23:
Enamines derived from 4-(alkylthio)-3-imidazolines and aldehydes have been added (ChemEurJ 2023, doi: 10.1002/chem.202302764). - 09/28/23:
Mesoionic N-heterocyclic olefins (mNHOs) have been added (Angew. Chem. Int. Ed. 2023, 62, e202309790). - 07/05/23:
S-Cyanomethylated imidazolidine-4-thione-derived enamines have been added (ChemComm 2023, 59, 8091). - 03/16/23:
Cyclic alpha-diazo carbonyl compounds added (EurJOC 2023, 26, e202300005) - 01/30/23:
NADH and NADPH reactivities (in water, pH 7) determined by Mayer and Moran have been added (OBC 2022, 21, 85-88). - 09/20/22:
Alkenyl boronate nucleophilicity by Liu, Ready and co-workers has been added (JACS 2022, 144, 16118). - 01/30/23:
Electrophilicities of diazo compounds in azo couplings (ChemEurJ 2022, 28, e202201376) - 01/30/23:
Diazocyclopentadiene added (Synthesis 2023, 55, 354-358) - 01/30/23:
Electrophilic indoles added (ChemCommun 2021, 57, 10071-10074) - 04/13/21:
Cyclic Michael acceptors added (Chem. Sci. 2021, 12, 4850-4865) - 05/21/21:
Thiophenolates (in DMSO) added (JOC 2021, 86, 5965-5972) - 05/06/20:
Heteroallenes added (JACS 2020, 142, 8383-8402). - 01/27/20:
Pyrrolidines and Imidazolidinones added (JACS 2020, 142, 1526-1547). - 05/06/20:
GSH reactivity added (Angew. Chem. Int. Ed. 2019, 58, 17704-17708) - 01/30/23:
Phenolates added (JOC 2019, 84, 8837-8858) - 04/24/18:
Ketones added (JACS 2018, 140, 5500). - 11/03/17:
Allyl-boron nucleophiles added (JACS 2017, 139, 15324) - 04/23/18:
Peroxide anions added (Angew. Chem. Int. Ed. 2017, 56, 13279). - 04/23/18:
Michael acceptors added (JACS 2017, 139, 13318). - 06/16/17:
Nucleophilicities of VNS reagents (JOC 2017, 82, 1011).