O-Nucleophiles
| Name | Solvent |
Reactivity Parameters |
Classification |
Reference (title or year) |
|---|---|---|---|---|
40% water/60%EtOH (v/v)  |
water-EtOH mix | N Param.: 6.28 sN Param.: 0.87 |  | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
33% ethanol/67% MeCN (v/v) |
EtOH-MeCN mix | N Param.: 6.06 sN Param.: 0.90 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
20% methanol/80% MeCN (v/v) |
MeOH-MeCN mix | N Param.: 6.04 sN Param.: 0.94 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
50% water/50%EtOH (v/v) |
water-EtOH mix | N Param.: 5.96 sN Param.: 0.89 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
60% water/40%EtOH (v/v) |
water-EtOH mix | N Param.: 5.81 sN Param.: 0.90 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
water (in MeCN) |
MeCN | N Param.: 5.79 sN Param.: 0.72 | | Bull. Chem. Soc. Jpn. 2018, 91, 523-530 10.1246/bcsj.20170360 |
20% water/80% acetone (v/v) |
water-acetone mix | N Param.: 5.77 sN Param.: 0.87 | | Angew. Chem. Int. Ed. 2004, 43, 2302-2305 10.1002/anie.200353468 |
20% ethanol/80% MeCN (v/v) |
EtOH-MeCN mix | N Param.: 5.77 sN Param.: 0.92 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
10% water/90% acetone (v/v) |
water-acetone mix | N Param.: 5.70 sN Param.: 0.85 | | Angew. Chem. Int. Ed. 2004, 43, 2302-2305 10.1002/anie.200353468 |
10% methanol/90% MeCN (v/v) |
MeOH-MeCN mix | N Param.: 5.55 sN Param.: 0.97 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
80% water/20%EtOH (v/v) |
water-EtOH mix | N Param.: 5.54 sN Param.: 0.94 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
90% water/10%EtOH (v/v) |
water-EtOH mix | N Param.: 5.38 sN Param.: 0.91 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
tert-butanol (in MeCN) |
MeCN | N Param.: 5.35 sN Param.: 0.72 | | Bull. Chem. Soc. Jpn. 2018, 91, 523-530 10.1246/bcsj.20170360 |
H2O (in water) |
water | N Param.: 5.20 sN Param.: 0.89 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
10% ethanol/90% MeCN (v/v) |
EtOH-MeCN mix | N Param.: 5.19 sN Param.: 0.96 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
91% water/9% MeCN (v/v) |
water-MeCN mix | N Param.: 5.16 sN Param.: 0.91 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
67% water/33% MeCN (v/v) |
water-MeCN mix | N Param.: 5.05 sN Param.: 0.90 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
50% water/50% MeCN (v/v) |
water-MeCN mix | N Param.: 5.05 sN Param.: 0.89 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
80% water/20% MeCN (v/v) |
water-MeCN mix | N Param.: 5.04 sN Param.: 0.89 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
90% water/10%TFE (v/v) |
water-TFE mix | N Param.: 5.04 sN Param.: 0.90 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
33% water/67% MeCN (v/v) |
water-MeCN mix | N Param.: 5.02 sN Param.: 0.90 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
20% water/80% MeCN (v/v) |
water-MeCN mix | N Param.: 5.02 sN Param.: 0.89 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
80% water/20%TFE (v/v) |
water-TFE mix | N Param.: 4.78 sN Param.: 0.83 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
10% water/90% MeCN (v/v) |
water-MeCN mix | N Param.: 4.56 sN Param.: 0.94 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
60% water/40%TFE (v/v) |
water-TFE mix | N Param.: 3.77 sN Param.: 0.88 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
50% water/50%TFE (v/v) |
water-TFE mix | N Param.: 3.57 sN Param.: 0.89 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
40% water/60%TFE (v/v) |
water-TFE mix | N Param.: 3.42 sN Param.: 0.90 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
20% water/80%TFE (v/v) |
water-TFE mix | N Param.: 3.20 sN Param.: 0.88 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
10% water/90%TFE (v/v) |
water-TFE mix | N Param.: 2.93 sN Param.: 0.88 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
30% water/70% HFIP (w/w) |
water-HFIP mix | N Param.: 1.65 sN Param.: 0.96 | | J. Phys. Org. Chem. 2013, 26, 59-63 10.1002/poc.3064 |
50% water/50% HFIP (w/w) |
water-HFIP mix | N Param.: 1.50 sN Param.: 1.03 | | J. Phys. Org. Chem. 2013, 26, 59-63 10.1002/poc.3064 |
trifluoroethanol |
TFE | N Param.: 1.11 sN Param.: 0.96 | | J. Am. Chem. Soc. 2012, 134, 13902-13911 10.1021/ja306522b |
10% water/90% HFIP (w/w) |
water-HFIP mix | N Param.: 0.96 sN Param.: 0.93 | | J. Phys. Org. Chem. 2013, 26, 59-63 10.1002/poc.3064 |
7% water/93% HFIP (w/w) |
water-HFIP mix | N Param.: 0.34 sN Param.: 0.96 | | J. Phys. Org. Chem. 2013, 26, 59-63 10.1002/poc.3064 |
5% water/95% HFIP (w/w) |
water-HFIP mix | N Param.: -0.10 sN Param.: 0.97 | | J. Phys. Org. Chem. 2013, 26, 59-63 10.1002/poc.3064 |
3% water/97% HFIP (w/w) |
water-HFIP mix | N Param.: -1.19 sN Param.: 1.08 | | J. Phys. Org. Chem. 2013, 26, 59-63 10.1002/poc.3064 |
2% water/98% HFIP (w/w) |
water-HFIP mix | N Param.: -1.62 sN Param.: 1.10 | | J. Phys. Org. Chem. 2013, 26, 59-63 10.1002/poc.3064 |
1% water/99% HFIP (w/w) |
water-HFIP mix | N Param.: -1.93 sN Param.: 1.09 | | J. Phys. Org. Chem. 2013, 26, 59-63 10.1002/poc.3064 |