Search
| Name | Solvent |
Reactivity Parameters |
Classification |
Reference (title or year) |
|---|---|---|---|---|
4-(dimethylamino)pyridine (in MeCN)  |
MeCN | N Param.: 15.51 sN Param.: 0.62 |  | J. Phys. Chem. A 2012, 116, 8494-8499 10.1021/jp3049247 |
N',N'-dimethylformohydrazide (in MeCN) |
MeCN | N Param.: 15.69 sN Param.: 0.51 | | J. Org. Chem. 2012, 77, 8142-8155 10.1021/jo301497g |
Dimedone iodonium ylide (in CH2Cl2) |
dichloromethane | N Param.: 6.18 sN Param.: 0.81 | | J. Am. Chem. Soc. 2016, 138, 10304-10313 10.1021/jacs.6b05768 |
N-(triisopropylsilyl)pyrrole |
dichloromethane | N Param.: 3.12 sN Param.: 0.93 | | Chem. Eur. J. 2003, 9, 2209-2218 10.1002/chem.200204666 |
dma(S)BBS |
E Param.: -10.73 | | J. Org. Chem. 2007, 72, 9170-9180 10.1021/jo071273g | |
3-(4-methoxybenzylidene)-1-methyl-3H-indol-1-ium iom |
E Param.: -3.02 | | J. Org. Chem. 2015, 80, 8643-8656 10.1021/acs.joc.5b01298 | |
3-chloro-benzaldehyde (in DMSO) |
DMSO |  | J. Am. Chem. Soc. 2011, 133, 8240-8251 10.1021/ja200820m | |
N-vinylcarbazole |
dichloromethane | N Param.: 5.02 sN Param.: 0.94 | | Macromolecules 2002, 35, 5454-5458 10.1021/ma020306l |
methyl(phenyl)methyleneammonium ion |
E Param.: -5.17 | | Acc. Chem. Res. 2003, 36, 66-77 10.1021/ar020094c | |
2-ethoxy-2-oxo-1-(pyridin-1-ium-1-yl)ethan-1-ide (in DMSO) |
DMSO | N Param.: 26.71 sN Param.: 0.37 | | J. Am. Chem. Soc. 2013, 135, 15216-15224 10.1021/ja407885h |
dimethyl(phenyl)silane |
dichloromethane | N Param.: 3.55 sN Param.: 0.75 | | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 |
pyrrole |
dichloromethane | N Param.: 4.63 sN Param.: 1.00 | | Chem. Eur. J. 2003, 9, 2209-2218 10.1002/chem.200204666 |
50% water/50%EtOH (v/v) |
water-EtOH mix | N Param.: 5.96 sN Param.: 0.89 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
1,2-diaza-1,3-diene 1c |
DMSO | E Param.: -14.91 | | Chem. Eur. J. 2010, 16, 12008-12016 10.1002/chem.201000828 |
pTolCH=N+CH2 (in MeCN) |
MeCN | E Param.: -9.64 | | J. Am. Chem. Soc. 2013, 135, 6579-6587 10.1021/ja401106x |
(jul)2CH+ |
E Param.: -9.45 | | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y | |
20% ethanol/80% MeCN (v/v) |
EtOH-MeCN mix | N Param.: 5.77 sN Param.: 0.92 | | J. Am. Chem. Soc. 2004, 126, 5174-5181 10.1021/ja031828z |
Me2S(O)=CH2 (in DMSO) |
DMSO | N Param.: 21.29 sN Param.: 0.47 | | J. Am. Chem. Soc. 2010, 132, 17894-17900 10.1021/ja1084749 |
MeO-Breslow 1a |
THF | N Param.: 14.77 sN Param.: 0.80 | | Angew. Chem. Int. Ed. 2012, 51, 10408-10412 10.1002/anie.201204524 |
diarylallylium ion (4-Br)2 |
E Param.: 2.85 | | J. Org. Chem. 2011, 76, 9391-9408 10.1021/jo201668w |
News
- 11/05/25:
Isochalcogenoureas (O, S, Se & Te derivatives) have been added (Angew. Chem. Int. Ed. 2025, EarlyView, e202514865). - 01/30/25:
Sesamol-derived ortho-quinone methides (o-QM) have been added (ChemEurJ 2024, e202403785 & OBC 2025, 23, 827-834) - 05/22/24:
Lactone enolates have been added (JOC 2024, 89, 6915-6928). - 11/13/24:
2-Methylene-1,2-dihydropyridines (2-pyNHOs) have been added (EurJOC 2024, 27, e202400373). - 05/21/24:
Mesoionic pyridinium-derived N-heterocyclic olefins (py-mNHOs) have been added (Angew. Chem. Int. Ed. 2024, 63, e202318283). - 10/19/23:
Enamines derived from 4-(alkylthio)-3-imidazolines and aldehydes have been added (ChemEurJ 2023, doi: 10.1002/chem.202302764). - 09/28/23:
Mesoionic N-heterocyclic olefins (mNHOs) have been added (Angew. Chem. Int. Ed. 2023, 62, e202309790). - 07/05/23:
S-Cyanomethylated imidazolidine-4-thione-derived enamines have been added (ChemComm 2023, 59, 8091). - 03/16/23:
Cyclic alpha-diazo carbonyl compounds added (EurJOC 2023, 26, e202300005) - 01/30/23:
NADH and NADPH reactivities (in water, pH 7) determined by Mayer and Moran have been added (OBC 2022, 21, 85-88). - 09/20/22:
Alkenyl boronate nucleophilicity by Liu, Ready and co-workers has been added (JACS 2022, 144, 16118). - 01/30/23:
Electrophilicities of diazo compounds in azo couplings (ChemEurJ 2022, 28, e202201376) - 01/30/23:
Diazocyclopentadiene added (Synthesis 2023, 55, 354-358) - 01/30/23:
Electrophilic indoles added (ChemCommun 2021, 57, 10071-10074) - 04/13/21:
Cyclic Michael acceptors added (Chem. Sci. 2021, 12, 4850-4865) - 05/21/21:
Thiophenolates (in DMSO) added (JOC 2021, 86, 5965-5972) - 05/06/20:
Heteroallenes added (JACS 2020, 142, 8383-8402). - 01/27/20:
Pyrrolidines and Imidazolidinones added (JACS 2020, 142, 1526-1547). - 05/06/20:
GSH reactivity added (Angew. Chem. Int. Ed. 2019, 58, 17704-17708) - 01/30/23:
Phenolates added (JOC 2019, 84, 8837-8858) - 04/24/18:
Ketones added (JACS 2018, 140, 5500). - 11/03/17:
Allyl-boron nucleophiles added (JACS 2017, 139, 15324) - 04/23/18:
Peroxide anions added (Angew. Chem. Int. Ed. 2017, 56, 13279). - 04/23/18:
Michael acceptors added (JACS 2017, 139, 13318). - 06/16/17:
Nucleophilicities of VNS reagents (JOC 2017, 82, 1011).