Nucleophiles
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« Back Forward » Found 1310 molecules, displaying page 11 of 14 Results per page
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| Name | Solvent |
Reactivity Parameters |
Classification |
Reference (title or year) |
|---|---|---|---|---|
anion of dimedone (in DMSO)  |
DMSO | N Param.: 16.27 sN Param.: 0.77 |  | Angew. Chem. Int. Ed. 2002, 41, 91-95 10.1002/1521-3773(20[...] |
cyanide (in MeCN) |
MeCN | N Param.: 16.27 sN Param.: 0.70 | | Angew. Chem. Int. Ed. 2005, 44, 142-145 10.1002/anie.200461640 |
anion of 4-cyanobenzyl trifluoromethyl sulfone (in DMSO) |
DMSO | N Param.: 16.28 sN Param.: 0.75 | | J. Am. Chem. Soc. 2007, 129, 9753-9761 10.1021/ja072135b |
DBN (in MeCN) |
MeCN | N Param.: 16.28 sN Param.: 0.67 | | Chem. Commun. 2008, , 1792-1794 10.1039/b801811a |
anion of (4-nitrophenyl)nitromethane (in DMSO) |
DMSO | N Param.: 16.29 sN Param.: 0.75 | | J. Org. Chem. 2004, 69, 7565-7576 10.1021/jo048773j |
benzotriazole anion (in DMSO) |
DMSO | N Param.: 16.29 sN Param.: 0.65 | | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 |
azide ion (in 91E9AN) |
EtOH-MeCN mix | N Param.: 16.30 sN Param.: 0.73 | | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 |
1-methyl uracil anion (in DMSO) |
DMSO | N Param.: 16.36 sN Param.: 0.69 | | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 |
pyridin-4-yl((trifluoromethyl)sulfonyl)amide (Ph4P+) (in MeCN) |
MeCN | N Param.: 16.38 sN Param.: 0.60 | | J. Am. Chem. Soc. 2025, 147, 5043-5050 10.1021/jacs.4c14825 |
4-formyl-imidazole anion (in DMSO) |
DMSO | N Param.: 16.40 sN Param.: 0.67 | | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 |
1-(N-pyrrolidino)cyclohexene (in MeCN) |
MeCN | N Param.: 16.42 sN Param.: 0.70 | | Angew. Chem. Int. Ed. 2010, 49, 9526-9529 10.1002/anie.201004344 |
(R)-2-isopropylpyrrolidine |
MeCN | N Param.: 16.44 sN Param.: 0.71 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
hydrazine (in MeCN) |
MeCN | N Param.: 16.45 sN Param.: 0.56 | | Angew. Chem. Int. Ed. 2012, 51, 1353-1356 10.1002/anie.201107315 |
benzoate (inMeCN) |
MeCN | N Param.: 16.45 sN Param.: 0.72 | | J. Am. Chem. Soc. 2020, 142, 5221-5233 10.1021/jacs.9b12998 |
pyridin-4-yl((trifluoromethyl)sulfonyl)amide (Bu4P+) (in MeCN) |
MeCN | N Param.: 16.48 sN Param.: 0.60 | | J. Org. Chem. 2025, 90, 2298-2306 10.1021/acs.joc.4c02668 |
N-methyl-morpholine (in CH2Cl2) |
dichloromethane | N Param.: 16.50 sN Param.: 0.52 | | J. Phys. Org. Chem. 2010, 23, 1029-1035 10.1002/poc.1707 |
(R)-2-isopropyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine |
dichloromethane | N Param.: 16.50 sN Param.: 0.48 | | J. Org. Chem. 2011, 76, 5104-5112 10.1021/jo200803x |
(S)-2-(methoxymethyl)pyrrolidine |
MeCN | N Param.: 16.50 sN Param.: 0.71 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
3-(tert-butyl)-1-methyl-1H-imidazol-3-ium-2-ide (in THF) |
THF | N Param.: 16.54 sN Param.: 0.47 | | Org. Lett. 2016, 18, 3566-3569 10.1021/acs.orglett.[...] |
anion of 3-oxo-3-phenylpropanenitrile (in DMSO) |
DMSO | N Param.: 16.55 sN Param.: 0.78 | | Chem. Eur. J. 2015, 21, 875-884 10.1002/chem.201404500 |
MeO-Breslow 1c |
THF | N Param.: 16.61 sN Param.: 0.68 | | Angew. Chem. Int. Ed. 2012, 51, 10408-10412 10.1002/anie.201204524 |
(S)-2-benzhydrylpyrrolidine |
MeCN | N Param.: 16.61 sN Param.: 0.67 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
2-Me super-dmap (in MeCN) |
MeCN | N Param.: 16.65 sN Param.: 0.58 | | Org. Lett. 2011, 13, 530-533 10.1021/ol1029589 |
o-nitrophenolate (in DMF) |
DMF | N Param.: 16.65 sN Param.: 0.70 | | J. Org. Chem. 2019, 84, 8837-8858 10.1021/acs.joc.9b01485 |
pyridin-4-yl((trifluoromethyl)sulfonyl)amide (Bu4N+) (in MeCN) |
MeCN | N Param.: 16.68 sN Param.: 0.59 | | J. Org. Chem. 2025, 90, 2298-2306 10.1021/acs.joc.4c02668 |
hypobromite (in water) |
water | N Param.: 16.69 sN Param.: 0.46 | | Org. Lett. 2018, 20, 2816-2820 10.1021/acs.orglett.[...] |
azide ion (in 91nPr9AN) |
nPrOH-MeCN mix | N Param.: 16.70 sN Param.: 0.73 | | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 |
n-propanolate (in 91nPr9AN) |
nPrOH-MeCN mix | N Param.: 16.73 sN Param.: 0.63 | | Can. J. Chem. 2005, 83, 1554-1560 10.1139%2Fv05-170 |
(Z)-2-phenyl-1-(1,3,4-triphenyl-4H-1,2,4-triazol-1-ium-5-yl)prop-1-en-1-olate (in THF) |
THF | N Param.: 16.73 sN Param.: 0.63 | | Angew. Chem. Int. Ed. 2013, 52, 11163-11167 10.1002/ange.201303524 |
anion of diethyl 2-(p-anisyl)malonate (in DMSO) |
DMSO | N Param.: 16.73 sN Param.: 0.91 | | Eur. J. Org. Chem. 2016, , 1841-1848 10.1002/ejoc.201600107 |
(S)-pyrrolidin-2-ylmethanol |
MeCN | N Param.: 16.74 sN Param.: 0.67 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
2-methylpyrrolidine (in MeCN) |
MeCN | N Param.: 16.78 sN Param.: 0.71 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
N-methyl-morpholine (in MeCN) |
MeCN | N Param.: 16.80 sN Param.: 0.52 | | J. Phys. Org. Chem. 2010, 23, 1029-1035 10.1002/poc.1707 |
1-methyl-2-phenylpyrrolidine (in CH2Cl2) |
dichloromethane | N Param.: 16.80 sN Param.: 0.49 | | J. Phys. Org. Chem. 2016, 29, 759-767 10.1002/poc.3580 |
2-Et super-dmap (in MeCN) |
MeCN | N Param.: 16.81 sN Param.: 0.60 | | Org. Lett. 2011, 13, 530-533 10.1021/ol1029589 |
benzoate (in MeCN) |
MeCN | N Param.: 16.82 sN Param.: 0.70 | | J. Am. Chem. Soc. 2008, 130, 3012-3022 10.1021/ja0765464 |
SO3(2-) (in water) |
water | N Param.: 16.83 sN Param.: 0.56 | | J. Am. Chem. Soc. 2003, 125, 286-295 10.1021/ja021010y |
acetate (in MeCN) |
MeCN | N Param.: 16.90 sN Param.: 0.75 | | J. Am. Chem. Soc. 2008, 130, 3012-3022 10.1021/ja0765464 |
morpholine (in DMSO) |
DMSO | N Param.: 16.96 sN Param.: 0.67 | | J. Am. Chem. Soc. 2003, 125, 286-295 10.1021/ja021010y |
anion of (4-cyanophenyl)nitromethane (in DMSO) |
DMSO | N Param.: 16.96 sN Param.: 0.73 | | J. Org. Chem. 2004, 69, 7565-7576 10.1021/jo048773j |
3-acetyl-2-oxotetrahydro-2H-pyran-3-ide (in DMSO) |
DMSO | N Param.: 17.00 sN Param.: 0.74 | | Eur. J. Org. Chem. 2015, , 7594-7601 10.1002/ejoc.201501107 |
isopropanolate (in propan-2-ol) |
iPrOH | N Param.: 17.03 sN Param.: 0.63 | | Can. J. Chem. 2005, 83, 1554-1560 10.1139%2Fv05-170 |
uracil anion (in DMSO) |
DMSO | N Param.: 17.04 sN Param.: 0.63 | | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 |
azide ion (in 91iPr9AN) |
iPrOH-MeCN mix | N Param.: 17.07 sN Param.: 0.71 | | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 |
triethylamine (in MeCN) |
MeCN | N Param.: 17.10 sN Param.: 0.52 | | J. Phys. Org. Chem. 2010, 23, 1029-1035 10.1002/poc.1707 |
dimethylamine (in water) |
water | N Param.: 17.12 sN Param.: 0.50 | | J. Org. Chem. 2007, 72, 3679-3688 10.1021/jo062586z |
Desoxy Breslow intermediate 2a |
THF | N Param.: 17.12 sN Param.: 0.80 | | Angew. Chem. Int. Ed. 2012, 51, 6231-6235 10.1002/anie.201202327 |
p-toluenesulfonamide anion (in DMSO) |
DMSO | N Param.: 17.14 sN Param.: 0.60 | | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 |
piperidine (in DMSO) |
DMSO | N Param.: 17.19 sN Param.: 0.71 | | J. Am. Chem. Soc. 2003, 125, 286-295 10.1021/ja021010y |
anion of 1-phenyl-2-(phenylsulfonyl)ethanone (in DMSO) |
DMSO | N Param.: 17.19 sN Param.: 0.56 | | Chem. Eur. J. 2015, 21, 875-884 10.1002/chem.201404500 |
pyridin-4-yl(tosyl)amide (Ph4P+) (in MeCN) |
MeCN | N Param.: 17.19 sN Param.: 0.64 | | J. Org. Chem. 2025, 90, 2298-2306 10.1021/acs.joc.4c02668 |
chloride (in MeCN) |
MeCN | N Param.: 17.20 sN Param.: 0.60 | | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n |
nitrite ion (in MeCN) |
MeCN | N Param.: 17.20 sN Param.: 0.72 | | Angew. Chem. Int. Ed. 2005, 44, 4623-4626 10.1002/anie.200501274 |
pyrrolidine (in water) |
water | N Param.: 17.21 sN Param.: 0.49 | | J. Org. Chem. 2007, 72, 3679-3688 10.1021/jo062586z |
piperazine (in water) |
water | N Param.: 17.22 sN Param.: 0.50 | | J. Org. Chem. 2007, 72, 3679-3688 10.1021/jo062586z |
methylhydrazine (in water) |
water | N Param.: 17.23 sN Param.: 0.45 | | J. Org. Chem. 2012, 77, 8142-8155 10.1021/jo301497g |
(S)-pyrrolidin-2-ylmethanamine |
MeCN | N Param.: 17.24 sN Param.: 0.67 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
((4-methoxyphenyl)sulfonyl)(pyridin-4-yl)amide (Ph4P+) (in MeCN) |
MeCN | N Param.: 17.28 sN Param.: 0.65 | | J. Am. Chem. Soc. 2025, 147, 5043-5050 10.1021/jacs.4c14825 |
methoxybis(phenylsulfonyl)methanide (in DMSO) |
DMSO | N Param.: 17.29 sN Param.: 0.70 | | Angew. Chem. Int. Ed. 2016, 55, 12845-12848 10.1002/anie.201605616 |
triethylamine (in CH2Cl2) |
dichloromethane | N Param.: 17.30 sN Param.: 0.52 | | J. Phys. Org. Chem. 2010, 23, 1029-1035 10.1002/poc.1707 |
anion of 4-(trifluoromethyl)benzyl trifluoromethyl sulfone (in DMSO) |
DMSO | N Param.: 17.33 sN Param.: 0.74 | | J. Am. Chem. Soc. 2007, 129, 9753-9761 10.1021/ja072135b |
piperidine (in MeCN) |
MeCN | N Param.: 17.35 sN Param.: 0.68 | | Eur. J. Org. Chem. 2009, , 6379-6385 10.1002/ejoc.200900925 |
2-methoxy-2H-benzo[d][1,3]dithiol-2-ide 1,1,3,3-tetraoxide (in DMSO) |
DMSO | N Param.: 17.36 sN Param.: 0.71 | | Angew. Chem. Int. Ed. 2016, 55, 12845-12848 10.1002/anie.201605616 |
Desoxy Breslow intermediate 2a |
DMSO | N Param.: 17.41 sN Param.: 0.74 | | Angew. Chem. Int. Ed. 2012, 51, 6231-6235 10.1002/anie.201202327 |
(S)-N,N-dimethyl-1-(pyrrolidin-2-yl)methanamine |
MeCN | N Param.: 17.41 sN Param.: 0.68 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
4-nitroperoxybenzoate (in H2O) |
water | N Param.: 17.43 sN Param.: 0.50 | | Angew. Chem. Int. Ed. 2017, 56, 13279-13282 10.1002/anie.201707086 |
2-benzylpyrrolidine |
MeCN | N Param.: 17.43 sN Param.: 0.66 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
anion of 1,3-diphenylpropane-1,3-dione (in DMSO) |
DMSO | N Param.: 17.46 sN Param.: 0.65 | | Chem. Eur. J. 2015, 21, 875-884 10.1002/chem.201404500 |
fluorobis(phenylsulfonyl)methanide (in DMSO) |
DMSO | N Param.: 17.46 sN Param.: 0.73 | | Angew. Chem. Int. Ed. 2016, 55, 12845-12848 10.1002/anie.201605616 |
1,3-dimethylbarbiturate anion (in DMSO) |
DMSO | N Param.: 17.46 sN Param.: 0.72 | | J. Org. Chem. 2017, 82, 8476-8488 10.1021/acs.joc.7b01223 |
(S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyrrolidin-2-ylmethyl)urea |
MeCN | N Param.: 17.50 sN Param.: 0.64 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
4,4-dimethyl-glutarimide anion (in DMSO) |
DMSO | N Param.: 17.52 sN Param.: 0.63 | | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 |
hydantoin anion (in DMSO) |
DMSO | N Param.: 17.52 sN Param.: 0.55 | | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 |
anion of ethyl 3-oxo-3-phenylpropanoate (in DMSO) |
DMSO | N Param.: 17.52 sN Param.: 0.74 | | Chem. Eur. J. 2015, 21, 875-884 10.1002/chem.201404500 |
(S)-N,N-dimethylpyrrolidine-2-carboxamide |
MeCN | N Param.: 17.61 sN Param.: 0.67 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
thymine anion (in DMSO) |
DMSO | N Param.: 17.63 sN Param.: 0.62 | | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 |
anion of acetylacetone (in DMSO) |
DMSO | N Param.: 17.64 sN Param.: 0.73 | | Angew. Chem. Int. Ed. 2002, 41, 91-95 10.1002/1521-3773(20[...] |
anion of diethyl methylmalonate (in water) |
water | N Param.: 17.68 sN Param.: 0.50 | | J. Am. Chem. Soc. 2003, 125, 12980-12986 10.1021/ja036838e |
1,3-dimesityl-2,3-dihydro-1H-1,3,2-diazaphosphole (in MeCN) |
MeCN | N Param.: 17.68 sN Param.: 0.68 | | Angew. Chem. Int. Ed. 2019, 58, 5983-5987 10.1002/anie.201901456 |
2-Bn super-dmap (in MeCN) |
MeCN | N Param.: 17.69 sN Param.: 0.57 | | Org. Lett. 2011, 13, 530-533 10.1021/ol1029589 |
isopropanolate (in 91iPr9AN) |
iPrOH-MeCN mix | N Param.: 17.71 sN Param.: 0.58 | | Can. J. Chem. 2005, 83, 1554-1560 10.1139%2Fv05-170 |
methylhydrazine (in MeCN) |
MeCN | N Param.: 17.73 sN Param.: 0.58 | | J. Org. Chem. 2012, 77, 8142-8155 10.1021/jo301497g |
trimethylhydrazine (in MeCN) |
MeCN | N Param.: 17.75 sN Param.: 0.53 | | Angew. Chem. Int. Ed. 2012, 51, 1353-1356 10.1002/anie.201107315 |
1,3-dimesityl-2-methylene-2,3-dihydro-1H-imidazole (in THF) |
THF | N Param.: 17.80 sN Param.: 0.79 | | J. Org. Chem. 2021, 86, 2974-2985 10.1021/acs.joc.0c02838 |
4-methoxyperoxybenzoate (in H2O) |
water | N Param.: 17.84 sN Param.: 0.46 | | Angew. Chem. Int. Ed. 2017, 56, 13279-13282 10.1002/anie.201707086 |
p-cyanophenolate (in DMF) |
DMF | N Param.: 17.85 sN Param.: 0.71 | | J. Org. Chem. 2019, 84, 8837-8858 10.1021/acs.joc.9b01485 |
pyridin-4-yl((trifluoromethyl)sulfonyl)amide (Ph4P+) (in CH2Cl2) |
dichloromethane | N Param.: 17.88 sN Param.: 0.73 | | J. Am. Chem. Soc. 2025, 147, 5043-5050 10.1021/jacs.4c14825 |
N-methylenepyrrolidin-1-amine (in CH2Cl2) |
dichloromethane | N Param.: 17.90 sN Param.: 0.48 | | Angew. Chem. Int. Ed. 2013, 52, 11900-11904 10.1002/anie.201305092 |
3,5-dichloroperoxybenzoate (in H2O) |
water | N Param.: 17.93 sN Param.: 0.50 | | Angew. Chem. Int. Ed. 2017, 56, 13279-13282 10.1002/anie.201707086 |
thiocyanate (in MeCN) |
MeCN | N Param.: 17.94 sN Param.: 0.60 | | J. Am. Chem. Soc. 2003, 125, 14126-14132 10.1021/ja037317u |
dimethylamine (in MeCN) |
MeCN | N Param.: 17.96 sN Param.: 0.63 | | J. Org. Chem. 2012, 77, 8142-8155 10.1021/jo301497g |
1-(3-chloropyridin-1-ium-1-yl)-2-oxo-2-phenylethan-1-ide (in DMSO) |
DMSO | N Param.: 17.98 sN Param.: 0.63 | | J. Am. Chem. Soc. 2013, 135, 15216-15224 10.1021/ja407885h |
4-fluoroperoxybenzoate (in H2O) |
water | N Param.: 17.99 sN Param.: 0.47 | | Angew. Chem. Int. Ed. 2017, 56, 13279-13282 10.1002/anie.201707086 |
MeSO2-CH-CO2Et (in DMSO) |
DMSO | N Param.: 18.00 sN Param.: 0.66 | | Chem. Eur. J. 2010, 16, 8610-8614 10.1002/chem.201001455 |
adenine anion (in DMSO) |
DMSO | N Param.: 18.00 sN Param.: 0.55 | | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 |
anion of (3-nitrophenyl)nitromethane (in DMSO) |
DMSO | N Param.: 18.06 sN Param.: 0.71 | | J. Org. Chem. 2004, 69, 7565-7576 10.1021/jo048773j |
proline (anionic, in water) |
water | N Param.: 18.08 sN Param.: 0.50 | | Org. Biomol. Chem. 2007, 5, 3814-3820 10.1039/b713778h |
(1H-inden-1-yl)zinc(II) chloride*LiCl (in DMSO) |
DMSO | N Param.: 18.10 sN Param.: 0.46 | | Angew. Chem. Int. Ed. 2015, 54, 12497-12500 10.1002/anie.201501385 |
tris(2,6-dimethoxyphenyl)phosphane (in MeCN) |
MeCN | N Param.: 18.11 sN Param.: 0.62 |  | Chem. Eur. J. 2017, 23, 7422-7427 10.1002/chem.201701080 |
1,3-dimethyl-2-methyleneimidazolidine (in THF) |
THF | N Param.: 18.11 sN Param.: 0.68 | | J. Org. Chem. 2021, 86, 2974-2985 10.1021/acs.joc.0c02838 |