Mayr's Database of Reactivity Parameters

Nucleophiles

2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 Found 1310 molecules, displaying page 6 of 27 Results per page 10|50|100|all
Name Solvent Reactivity
Parameters 		Classification Reference
(title or year)
1-mesityl-3-methyl-5-methylene-2,4,6-triphenyl-2,5-dihydropyridin-1-ium-2-ide (in THF)
C34H31N*
 THF

N  Param.: 26.16

sN Param.: 0.52		***Angew. Chem. Int. Ed. 2024, , e202318283
10.1002/anie.202318283
1-methoxy-2-methyl-1-(trimethylsiloxy)propene
C8H18O2Si*
 dichloromethane

N  Param.: 9.00

sN Param.: 0.98		*****J. Am. Chem. Soc. 2001, 123, 9500-9512
10.1021/ja010890y
1-methoxy-2-methyl-1-(trimethylsiloxy)propene (in MeCN)
*
 MeCN

N  Param.: 9.11

sN Param.: 0.88		***J. Am. Chem. Soc. 2013, 135, 6579-6587
10.1021/ja401106x
1-methyl uracil anion (in DMSO)
*
 DMSO

N  Param.: 16.36

sN Param.: 0.69		***Chem. Eur. J. 2012, 18, 127-137
10.1002/chem.201102411
1-methyl uracil anion (in water)
*
 water

N  Param.: 8.54

sN Param.: 0.77		***Chem. Eur. J. 2012, 18, 127-137
10.1002/chem.201102411
1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine (MeTBD)
C8H15N3*
 dichloromethane

N  Param.: 14.43

sN Param.: 0.81		***ChemCatChem 2012, 4, 993-999
10.1002/cctc.201200143
1-methyl-2-methylene-3-phenyl-1,2-dihydropyridine (in DMSO)
C13H13N*
 DMSO

N  Param.: 19.41

sN Param.: 0.61		***Eur. J. Org. Chem. 2024, 27, e202400373
10.1002/ejoc.202400373
1-methyl-2-phenylpyrrolidine (in CH2Cl2)
C11H15N*
 dichloromethane

N  Param.: 16.80

sN Param.: 0.49		***J. Phys. Org. Chem. 2016, 29, 759-767
10.1002/poc.3580
1-methyl-2-phenylpyrrolidine (in MeCN)
C11H15N*
 MeCN

N  Param.: 15.70

sN Param.: 0.54		***J. Phys. Org. Chem. 2016, 29, 759-767
10.1002/poc.3580
1-methyl-4-(N-morpholino)tetrahydropyridine
C10H18N2O*
 dichloromethane

N  Param.: 12.03

sN Param.: 0.80		*Chem. Eur. J. 2003, 9, 2209-2218
10.1002/chem.200204666
1-methyl-4-vinyl-benzene
C9H10*
 dichloromethane

N  Param.: 1.70

sN Param.: 1.06		*****J. Am. Chem. Soc. 2001, 123, 9500-9512
10.1021/ja010890y
1-methyl-benzimidazole (in MeCN)
*
 MeCN

N  Param.: 10.37

sN Param.: 0.82		***Org. Biomol. Chem. 2010, 8, 1929-1935
10.1039/c000965b
1-methyl-benzotriazole (in MeCN)
*
 MeCN

N  Param.: 7.77

sN Param.: 0.76		*Org. Biomol. Chem. 2010, 8, 1929-1935
10.1039/c000965b
1-methyl-imidazole (in MeCN)
*
 MeCN

N  Param.: 11.90

sN Param.: 0.73		***Org. Biomol. Chem. 2010, 8, 1929-1935
10.1039/c000965b
1-methyl-imidazole (in water)
*
 water

N  Param.: 9.91

sN Param.: 0.55		***Org. Biomol. Chem. 2010, 8, 1929-1935
10.1039/c000965b
1-methylcyclohexene
C7H12*
 dichloromethane

N  Param.: 0.08

sN Param.: 1.15		*****J. Am. Chem. Soc. 2001, 123, 9500-9512
10.1021/ja010890y
1-methylcyclopentene
C6H10*
 dichloromethane

N  Param.: 1.18

sN Param.: 1.17		*****J. Am. Chem. Soc. 2012, 134, 13902-13911
10.1021/ja306522b
1-methylsiletane
C4H10Si*
 dichloromethane

N  Param.: 2.30

sN Param.: 0.75		-Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
1-methylsilolane
C5H12Si*
 dichloromethane

N  Param.: 2.20

sN Param.: 0.75		-Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
1-phenoxy-1-(trimethylsiloxy)ethene
C11H16O2Si*
 dichloromethane

N  Param.: 8.23

sN Param.: 0.81		*****J. Am. Chem. Soc. 2001, 123, 9500-9512
10.1021/ja010890y
1-phenyl-1-(trimethylsiloxy)ethene
C11H16OSi*
 dichloromethane

N  Param.: 6.22

sN Param.: 0.96		*****J. Am. Chem. Soc. 2001, 123, 9500-9512
10.1021/ja010890y
1-phenyl-imidazole (in MeCN)
*
 MeCN

N  Param.: 11.31

sN Param.: 0.67		***Org. Biomol. Chem. 2010, 8, 1929-1935
10.1039/c000965b
1-phenyl-N-(phenylmethyl)methanimine (in CH2Cl2)
C14H13N*
 dichloromethane

N  Param.: 7.90

sN Param.: 0.76		**Z. Naturforsch. B 2013, 68b, 693-699
10.5560/ZNB.2013-3085
1-pyrrolidino-3,4-dihydronaphthalene (in MeCN)
C14H17N*
 MeCN

N  Param.: 14.09

sN Param.: 0.66		***Synthesis 2019, 51, 1157-1170
10.1055/s-0037-1611634
10% ethanol/90% MeCN (v/v)
C2H6O*
 EtOH-MeCN mix

N  Param.: 5.19

sN Param.: 0.96		***J. Am. Chem. Soc. 2004, 126, 5174-5181
10.1021/ja031828z
10% methanol/90% MeCN (v/v)
CH4O*
 MeOH-MeCN mix

N  Param.: 5.55

sN Param.: 0.97		***J. Am. Chem. Soc. 2004, 126, 5174-5181
10.1021/ja031828z
10% water/90% acetone (v/v)
H2O*
 water-acetone mix

N  Param.: 5.70

sN Param.: 0.85		***Angew. Chem. Int. Ed. 2004, 43, 2302-2305
10.1002/anie.200353468
10% water/90% HFIP (w/w)
*
 water-HFIP mix

N  Param.: 0.96

sN Param.: 0.93		***J. Phys. Org. Chem. 2013, 26, 59-63
10.1002/poc.3064
10% water/90% MeCN (v/v)
H2O*
 water-MeCN mix

N  Param.: 4.56

sN Param.: 0.94		***J. Am. Chem. Soc. 2004, 126, 5174-5181
10.1021/ja031828z
10% water/90%EtOH (v/v)
*
 water-EtOH mix

N  Param.: 7.03

sN Param.: 0.86		***J. Am. Chem. Soc. 2004, 126, 5174-5181
10.1021/ja031828z
10% water/90%TFE (v/v)
H2O*
 water-TFE mix

N  Param.: 2.93

sN Param.: 0.88		***J. Am. Chem. Soc. 2004, 126, 5174-5181
10.1021/ja031828z
10-methyl-9,10-dihydroacridine
*
 dichloromethane

N  Param.: 5.54

sN Param.: 0.90		*Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
10-methyl-9,10-dihydroacridine (in MeCN)
C14H13N*
 MeCN

N  Param.: 4.00

sN Param.: 0.70		-Chem. Eur. J. 2013, 19, 249-263
10.1002/chem.201202839
1H-indole-5-carboxylic acid
C9H7NO2*
 MeCN

N  Param.: 3.97

sN Param.: 1.10		*J. Org. Chem. 2006, 71, 9088-9095
10.1021/jo0614339
2% water/98% HFIP (w/w)
*
 water-HFIP mix

N  Param.: -1.62

sN Param.: 1.10		***J. Phys. Org. Chem. 2013, 26, 59-63
10.1002/poc.3064
2,2,2-trifluoroethanolate (in water)
C2H2F3O*
 water

N  Param.: 12.66

sN Param.: 0.59		***J. Am. Chem. Soc. 2003, 125, 286-295
10.1021/ja021010y
2,2,2-trifluoroethylamine (in 91M9AN)
C2H4F3N*
 MeOH-MeCN mix

N  Param.: 10.20

sN Param.: 0.92		***Angew. Chem. Int. Ed. 2006, 45, 3869-3874
10.1002/anie.200600542
2,2,2-trifluoroethylamine (in DMSO)
C2H4F3N*
 DMSO

N  Param.: 12.15

sN Param.: 0.65		***J. Am. Chem. Soc. 2003, 125, 286-295
10.1021/ja021010y
2,2,2-trifluoroethylamine (in MeCN)
*
 MeCN

N  Param.: 10.13

sN Param.: 0.75		***Eur. J. Org. Chem. 2009, , 6379-6385
10.1002/ejoc.200900925
2,2-dimethyl-5-(4-nitrobenzyl)-4,6-dioxo-1,3-dioxan-5-ide (in DMSO)
C13H12NO6*
 DMSO

N  Param.: 12.02

sN Param.: 1.17		***Chem. Eur. J. 2014, 20, 11069-11077
10.1002/chem.201403161
2,2-dimethylpyrrolidine
C6H13N*
 MeCN

N  Param.: 13.96

sN Param.: 0.76		***J. Am. Chem. Soc. 2020, 142, 1526-1547
10.1021/jacs.9b11877
2,3,3-trimethyl-but-1-ene
C7H14*
 dichloromethane

N  Param.: 0.06

sN Param.: 1.07		*****J. Am. Chem. Soc. 2012, 134, 13902-13911
10.1021/ja306522b
2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine
C7H13N3*
 dichloromethane

N  Param.: 16.16

sN Param.: 0.75		***ChemCatChem 2012, 4, 993-999
10.1002/cctc.201200143
2,3,4,6,7,8-hexahydropyrimido[2,1-b][1,3]thiazine
*
 dichloromethane

N  Param.: 14.10

sN Param.: 0.82		***J. Org. Chem. 2011, 76, 5104-5112
10.1021/jo200803x
2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole (TBO)
C5H9N3*
 dichloromethane

N  Param.: 14.44

sN Param.: 0.79		***ChemCatChem 2012, 4, 993-999
10.1002/cctc.201200143
2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
*
 dichloromethane

N  Param.: 12.98

sN Param.: 0.81		***J. Org. Chem. 2011, 76, 5104-5112
10.1021/jo200803x
2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole
*
 dichloromethane

N  Param.: 13.42

sN Param.: 0.73		***J. Org. Chem. 2011, 76, 5104-5112
10.1021/jo200803x
2,3-dihydrofuran
C4H6O*
 dichloromethane

N  Param.: 4.37

sN Param.: 0.90		****Eur. J. Org. Chem. 2005, , 1760-1764
10.1002/ejoc.200400706
2,3-dimethyl-but-1-ene
C6H12*
 dichloromethane

N  Param.: 0.65

sN Param.: 1.00		*****J. Am. Chem. Soc. 2012, 134, 13902-13911
10.1021/ja306522b
2,3-dimethyl-buta-1,3-diene
C6H10*
 dichloromethane

N  Param.: 1.17

sN Param.: 1.00		*Acc. Chem. Res. 2003, 36, 66-77
10.1021/ar020094c