Nucleophiles
Name | Solvent |
Reactivity Parameters |
Classification |
Reference (title or year) |
---|---|---|---|---|
anion of nitromethane (in water) | water | N Param.: 12.06 sN Param.: 0.53 | J. Org. Chem. 2004, 69, 7565-7576 10.1021/jo048773j | |
anion of p-tolylnitromethane (in 91M9AN) | MeOH-MeCN mix | N Param.: 13.58 sN Param.: 0.64 | Eur. J. Org. Chem. 2006, , 2530-2537 10.1002/ejoc.200500769 | |
anion of p-tolylnitromethane (in DMSO) | DMSO | N Param.: 18.31 sN Param.: 0.76 | J. Org. Chem. 2004, 69, 7565-7576 10.1021/jo048773j | |
anion of p-tolylnitromethane (in water) | water | N Param.: 13.09 sN Param.: 0.50 | J. Org. Chem. 2004, 69, 7565-7576 10.1021/jo048773j | |
anion of phenylnitromethane (in 91M9AN) | MeOH-MeCN mix | N Param.: 12.51 sN Param.: 0.67 | Eur. J. Org. Chem. 2006, , 2530-2537 10.1002/ejoc.200500769 | |
anion of phenylnitromethane (in DMSO) | DMSO | N Param.: 18.29 sN Param.: 0.71 | J. Org. Chem. 2004, 69, 7565-7576 10.1021/jo048773j | |
anion of phenylnitromethane (in H2O) | water | N Param.: 12.05 sN Param.: 0.53 | J. Org. Chem. 2004, 69, 7565-7576 10.1021/jo048773j | |
anion of triethyl methanetricarboxylate (in DMSO) | DMSO | N Param.: 15.33 sN Param.: 0.72 | Eur. J. Org. Chem. 2016, , 1841-1848 10.1002/ejoc.201600107 | |
anisole | dichloromethane | N Param.: -1.18 sN Param.: 1.20 | Acc. Chem. Res. 2003, 36, 66-77 10.1021/ar020094c | |
arginine (betaine, in water) | water | N Param.: 12.96 sN Param.: 0.57 | Org. Biomol. Chem. 2007, 5, 3814-3820 10.1039/b713778h | |
asparagine (anionic, in water) | water | N Param.: 13.03 sN Param.: 0.53 | Org. Biomol. Chem. 2007, 5, 3814-3820 10.1039/b713778h | |
aspartate (dianionic, in water) | water | N Param.: 13.81 sN Param.: 0.53 | Org. Biomol. Chem. 2007, 5, 3814-3820 10.1039/b713778h | |
azide ion (in 45M55AN) | MeOH-MeCN mix | N Param.: 15.01 sN Param.: 0.80 | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 | |
azide ion (in 91E9AN) | EtOH-MeCN mix | N Param.: 16.30 sN Param.: 0.73 | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 | |
azide ion (in 91iPr9AN) | iPrOH-MeCN mix | N Param.: 17.07 sN Param.: 0.71 | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 | |
azide ion (in 91M9AN) | MeOH-MeCN mix | N Param.: 14.54 sN Param.: 0.82 | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 | |
azide ion (in 91nPr9AN) | nPrOH-MeCN mix | N Param.: 16.70 sN Param.: 0.73 | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 | |
azide ion (in DMSO) | DMSO | N Param.: 20.50 sN Param.: 0.59 | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 | |
azulene | MeCN | N Param.: 6.66 sN Param.: 1.02 | Eur. J. Org. Chem. 2009, , 1202-1206 10.1002/ejoc.200801099 | |
barbiturate anion (in DMSO) | DMSO | N Param.: 15.59 sN Param.: 0.80 | J. Org. Chem. 2017, 82, 8476-8488 10.1021/acs.joc.7b01223 | |
benzimidazole (in DMSO) | DMSO | N Param.: 10.50 sN Param.: 0.79 | Org. Biomol. Chem. 2010, 8, 1929-1935 10.1039/c000965b | |
benzimidazole anion (in DMSO) | DMSO | N Param.: 19.13 sN Param.: 0.55 | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 | |
benzoate (in 90AN10W) | aq MeCN | N Param.: 11.30 sN Param.: 0.72 | J. Am. Chem. Soc. 2008, 130, 3012-3022 10.1021/ja0765464 | |
benzoate (in MeCN) | MeCN | N Param.: 16.82 sN Param.: 0.70 | J. Am. Chem. Soc. 2008, 130, 3012-3022 10.1021/ja0765464 | |
benzoate (inMeCN) | MeCN | N Param.: 16.45 sN Param.: 0.72 | J. Am. Chem. Soc. 2020, 142, 5221-5233 10.1021/jacs.9b12998 | |
benzohydrazide (in MeCN) | MeCN | N Param.: 12.49 sN Param.: 0.66 | J. Org. Chem. 2012, 77, 8142-8155 10.1021/jo301497g | |
benzotriazole (in MeCN) | MeCN | N Param.: 7.69 sN Param.: 0.76 | Org. Biomol. Chem. 2010, 8, 1929-1935 10.1039/c000965b | |
benzotriazole anion (in DMSO) | DMSO | N Param.: 16.29 sN Param.: 0.65 | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 | |
benzotriazole anion (in water) | water | N Param.: 11.52 sN Param.: 0.67 | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 | |
benzyl (1-phenylvinyl)carbamate | MeCN | N Param.: 6.21 sN Param.: 0.87 | Chem. Eur. J. 2012, 18, 5732-5740 10.1002/chem.201103519 | |
benzyl isocyanide | dichloromethane | N Param.: 4.90 sN Param.: 0.74 | Angew. Chem. Int. Ed. 2007, 46, 3563-3566 10.1002/anie.200605205 | |
benzylamine (in 91M9AN) | MeOH-MeCN mix | N Param.: 13.46 sN Param.: 0.62 | Angew. Chem. Int. Ed. 2006, 45, 3869-3874 10.1002/anie.200600542 | |
benzylamine (in DMSO) | DMSO | N Param.: 15.28 sN Param.: 0.65 | J. Am. Chem. Soc. 2009, 131, 11392-11401 10.1021/ja903207b | |
benzylamine (in MeCN) | MeCN | N Param.: 14.29 sN Param.: 0.67 | Eur. J. Org. Chem. 2009, , 6379-6385 10.1002/ejoc.200900925 | |
benzylamine (in water) | water | N Param.: 13.44 sN Param.: 0.55 | J. Org. Chem. 2007, 72, 3679-3688 10.1021/jo062586z | |
benzyldimethylsilane | dichloromethane | N Param.: 2.78 sN Param.: 0.73 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
beta-(trimethylsilyl)styrene | dichloromethane | N Param.: -0.43 sN Param.: 1.06 | Chem. Eur. J. 2014, 20, 1103-1110 10.1002/chem.201303215 | |
beta-alanine (anionic, in water) | water | N Param.: 13.26 sN Param.: 0.58 | Org. Biomol. Chem. 2007, 5, 3814-3820 10.1039/b713778h | |
beta-piperidinium-peroxypropionate | water | N Param.: 13.94 sN Param.: 0.62 | Eur. J. Org. Chem. 2018, , 6010-6017 10.1002/ejoc.201801158 | |
bis(4-(dimethylamino)phenyl)phenylmethane (in MeCN) | MeCN | N Param.: -4.20 sN Param.: 0.82 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
bis(4-methoxyphenyl)methane (in CH2Cl2) | dichloromethane | N Param.: -2.11 sN Param.: 0.98 | J. Am. Chem. Soc. 2014, 136, 13863-13873 10.1021/ja507598y | |
bis(4-methoxyphenyl)phenylmethane (in MeCN) | MeCN | N Param.: -7.00 sN Param.: 0.82 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
bis(4-nitrophenyl)methanide (in DMSO) | DMSO | N Param.: 19.92 sN Param.: 0.67 | ARKIVOC 2008, (x), 37-53 10.3998/ark.5550190.[...] | |
bis(phenylsulfonyl)methanide (in DMSO) | DMSO | N Param.: 15.68 sN Param.: 0.74 | Angew. Chem. Int. Ed. 2016, 55, 12845-12848 10.1002/anie.201605616 | |
borane-2,6-lutidine-complex | dichloromethane | N Param.: 10.33 sN Param.: 0.75 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
borane-4-methoxypyridine-complex | dichloromethane | N Param.: 11.01 sN Param.: 0.75 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
borane-4-tBu-pyridine-complex | dichloromethane | N Param.: 10.46 sN Param.: 0.75 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
borane-DMAP-complex | dichloromethane | N Param.: 12.44 sN Param.: 0.76 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
borane-N,N-diethylaniline-complex | dichloromethane | N Param.: 8.53 sN Param.: 0.75 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
borane-N,N-diisopropylaniline-complex | dichloromethane | N Param.: 8.84 sN Param.: 0.75 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
borane-N-ethyl-N-isopropylaniline-complex | dichloromethane | N Param.: 9.12 sN Param.: 0.75 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
borane-pyridine-complex | dichloromethane | N Param.: 10.01 sN Param.: 0.75 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
borane-triethylamine-complex | dichloromethane | N Param.: 8.90 sN Param.: 0.75 | J. Am. Chem. Soc. 2001, 123, 9500-9512 10.1021/ja010890y | |
borane-trimethylamine-complex | dichloromethane | N Param.: 7.97 sN Param.: 0.75 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
bromide (in 20% aq MeCN) | water-MeCN mix | N Param.: 12.20 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
bromide (in 40% aq MeCN) | water-MeCN mix | N Param.: 12.80 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
bromide (in 50% aq EtOH) | water-EtOH mix | N Param.: 13.60 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
bromide (in 50% aq MeCN) | water-MeCN mix | N Param.: 13.80 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
bromide (in 80% aq EtOH) | water-EtOH mix | N Param.: 14.50 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
bromide (in CF3CH2OH) | TFE | N Param.: 11.70 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
bromide (in H2O) | water | N Param.: 11.70 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
bromite (in water) | water | N Param.: 12.75 sN Param.: 0.59 | Org. Lett. 2018, 20, 2816-2820 10.1021/acs.orglett.[...] | |
bromo(phenylsulfonyl)methanide (in DMSO) | DMSO | N Param.: 23.90 sN Param.: 0.62 | J. Org. Chem. 2017, 82, 2011-2017 10.1021/acs.joc.6b02844 | |
bromoborane-triethylamine-complex | dichloromethane | N Param.: 7.49 sN Param.: 0.75 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
Bu4NBH4 (in DMSO) | DMSO | N Param.: 14.94 sN Param.: 0.79 | Angew. Chem. Int. Ed. 2009, 48, 1958-1961 10.1002/anie.200804263 | |
buta-1,3-diene | dichloromethane | N Param.: -0.87 sN Param.: 1.00 | Acc. Chem. Res. 2003, 36, 66-77 10.1021/ar020094c | |
butyltrimethylsilane | dichloromethane | N Param.: -5.40 sN Param.: 1.10 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
chloride (in 20% aq MeCN) | water-MeCN mix | N Param.: 11.31 sN Param.: 0.58 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in 40% aq MeCN) | water-MeCN mix | N Param.: 11.30 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in 50% aq EtOH) | water-EtOH mix | N Param.: 11.80 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in 50% aq MeCN) | water-MeCN mix | N Param.: 12.00 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in 50/50 MeOH/MeCN) | MeOH-MeCN mix | N Param.: 14.10 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in 60% aq MeCN) | water-MeCN mix | N Param.: 12.00 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in 80% aq EtOH) | water-EtOH mix | N Param.: 13.00 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in 80% aq MeCN) | water-MeCN mix | N Param.: 13.30 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in CF3CH2OH) | TFE | N Param.: 10.30 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in EtOH) | EtOH | N Param.: 14.70 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in H2O) | water | N Param.: 10.10 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in hexafluoroisopropanol) | HFIP | N Param.: 8.00 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in MeCN) | MeCN | N Param.: 17.20 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloride (in MeOH) | MeOH | N Param.: 12.90 sN Param.: 0.60 | J. Am. Chem. Soc. 2005, 127, 2641-2649 10.1021/ja045562n | |
chloro((4-chlorophenyl)sulfonyl)methanide (in DMSO) | DMSO | N Param.: 26.90 sN Param.: 0.45 | J. Org. Chem. 2017, 82, 2011-2017 10.1021/acs.joc.6b02844 | |
chloro((4-cyanophenyl)sulfonyl)methanide (in DMSO) | DMSO | N Param.: 25.59 sN Param.: 0.51 | J. Org. Chem. 2017, 82, 2011-2017 10.1021/acs.joc.6b02844 | |
chloro((4-nitrophenyl)sulfonyl)methanide (in DMSO) | DMSO | N Param.: 24.88 sN Param.: 0.49 | J. Org. Chem. 2017, 82, 2011-2017 10.1021/acs.joc.6b02844 | |
chloro(phenylsulfonyl)methanide (in DMF) | DMF | N Param.: 26.64 sN Param.: 0.64 | Chem. Eur. J. 2008, 14, 6108-6118 10.1002/chem.200800329 | |
chloro(phenylsulfonyl)methanide (in DMSO) | DMSO | N Param.: 28.27 sN Param.: 0.42 | J. Org. Chem. 2017, 82, 2011-2017 10.1021/acs.joc.6b02844 | |
chlorodimethylsilane | dichloromethane | N Param.: 0.79 sN Param.: 0.73 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
cis-HMn(PCy3)(CO)4 | dichloromethane | N Param.: 2.20 sN Param.: 0.80 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
cis-HMn(PPh3)(CO)4 | dichloromethane | N Param.: 2.30 sN Param.: 0.80 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
cis-HRe(PPh3)(CO)4 | dichloromethane | N Param.: 4.50 sN Param.: 0.80 | Chem. Eur. J. 2013, 19, 249-263 10.1002/chem.201202839 | |
Cp2Ti(CH2Ph)2 - Dibenzyltitanocene | dichloromethane | N Param.: 4.38 sN Param.: 1.00 | Chem. Eur. J. 2016, 22, 11196-11200 10.1002/chem.201602452 | |
Cp2Zr(CH2Ph)2 - Dibenzylzirconocene | dichloromethane | N Param.: 5.10 sN Param.: 1.03 | Chem. Eur. J. 2016, 22, 11196-11200 10.1002/chem.201602452 | |
Cp2Zr(Me)2 - Dimethylzirconocene | dichloromethane | N Param.: 4.35 sN Param.: 1.09 | Chem. Eur. J. 2016, 22, 11196-11200 10.1002/chem.201602452 | |
cumene peroxy anion (in H2O) | water | N Param.: 13.92 sN Param.: 0.61 | Angew. Chem. Int. Ed. 2017, 56, 13279-13282 10.1002/anie.201707086 | |
cyanamide anion (in DMSO) | DMSO | N Param.: 20.33 sN Param.: 0.64 | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 | |
cyanate (in MeCN) | MeCN | N Param.: 13.60 sN Param.: 0.84 | Chem. Eur. J. 2008, 14, 3866-3868 10.1002/chem.200800314 | |
cyanide (in MeCN) | MeCN | N Param.: 16.27 sN Param.: 0.70 | Angew. Chem. Int. Ed. 2005, 44, 142-145 10.1002/anie.200461640 | |
cyano((diphenylmethylene)amino)methanide | DMSO | N Param.: 29.50 sN Param.: 0.50 | Tetrahedron 2019, 75, 459-463 10.1016/j.tet.2018.1[...] | |
cyano(pyridin-1-ium-1-yl)methanide (in DMSO) | DMSO | N Param.: 25.94 sN Param.: 0.42 | J. Am. Chem. Soc. 2013, 135, 15216-15224 10.1021/ja407885h | |
cyanoborate ion (in water) | water | N Param.: 9.99 sN Param.: 0.54 | Org. Biomol. Chem. 2023, 21, 85-88 10.1039/D2OB02041F |