Nucleophiles
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« Back Forward » Found 1298 molecules, displaying page 4 of 13 Results per page
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| Name | Solvent |
Reactivity Parameters |
Classification |
Reference (title or year) |
|---|---|---|---|---|
1-ethoxy-3-(4-nitrophenyl)-1,3-dioxopropan-2-ide (in DMSO)  |
DMSO | N Param.: 16.26 sN Param.: 0.83 |  | J. Am. Chem. Soc. 2018, 140, 11474-11486 10.1021/jacs.8b07147 |
Me2S=CH-CN (in DMSO) |
DMSO | N Param.: 16.23 sN Param.: 0.60 | | Chem. Eur. J. 2010, 16, 8610-8614 10.1002/chem.201001455 |
(S)-diphenyl(pyrrolidin-2-yl)methanol |
MeCN | N Param.: 16.18 sN Param.: 0.56 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
tris(4-methoxyphenyl)phosphane |
dichloromethane | N Param.: 16.17 sN Param.: 0.62 | | Chem. Eur. J. 2005, 11, 917-927 10.1002/chem.200400696 |
2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine |
dichloromethane | N Param.: 16.16 sN Param.: 0.75 | | ChemCatChem 2012, 4, 993-999 10.1002/cctc.201200143 |
anion of diethyl malonate (in water) |
water | N Param.: 16.15 sN Param.: 0.66 | | J. Am. Chem. Soc. 2003, 125, 12980-12986 10.1021/ja036838e |
1,2,3,5,6,7-hexahydroimidazo[1,2-a]pyrimidine (TBN) |
dichloromethane | N Param.: 16.15 sN Param.: 0.73 | | ChemCatChem 2012, 4, 993-999 10.1002/cctc.201200143 |
1,2-dimethylhydrazine (in MeCN) |
MeCN | N Param.: 16.15 sN Param.: 0.68 | | J. Org. Chem. 2012, 77, 8142-8155 10.1021/jo301497g |
anion of 4-(trifluoromethyl)benzyl trifluoromethyl sulfone (in MeCN) |
MeCN | N Param.: 16.15 sN Param.: 0.99 | | J. Am. Chem. Soc. 2020, 142, 8383-8402 10.1021/jacs.0c01960 |
DBU (in THF) |
THF | N Param.: 16.12 sN Param.: 0.67 | | Angew. Chem. Int. Ed. 2011, 50, 6915-6919 10.1002/anie.201102435 |
ethanolate (in 91E9AN) |
EtOH-MeCN mix | N Param.: 16.08 sN Param.: 0.62 | | Can. J. Chem. 2005, 83, 1554-1560 10.1139%2Fv05-170 |
ethanolamine (in DMSO) |
DMSO | N Param.: 16.07 sN Param.: 0.61 | | J. Am. Chem. Soc. 2009, 131, 11392-11401 10.1021/ja903207b |
2-formyl-imidazole anion (in DMSO) |
DMSO | N Param.: 16.06 sN Param.: 0.68 | | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 |
2H-benzo[d][1,3]dithiol-2-ide 1,1,3,3-tetraoxide (in DMSO) |
DMSO | N Param.: 16.06 sN Param.: 0.69 | | Angew. Chem. Int. Ed. 2016, 55, 12845-12848 10.1002/anie.201605616 |
diacetamide anion (in DMSO) |
DMSO | N Param.: 16.05 sN Param.: 0.70 | | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 |
n-propanolate (in propan-1-ol) |
nPrOH | N Param.: 16.03 sN Param.: 0.70 | | Can. J. Chem. 2005, 83, 1554-1560 10.1139%2Fv05-170 |
succinimide anion (in DMSO) |
DMSO | N Param.: 16.03 sN Param.: 0.66 | | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 |
methyl carbonate (in MeCN) |
MeCN | N Param.: 16.03 sN Param.: 0.64 | | Eur. J. Org. Chem. 2010, , 4205-4210 10.1002/ejoc.201000414 |
anion of 1-phenylbutane-1,3-dione (in DMSO) |
DMSO | N Param.: 16.03 sN Param.: 0.86 | | Chem. Eur. J. 2015, 21, 875-884 10.1002/chem.201404500 |
phthalimidoperoxyhexanoate (in H2O) |
water | N Param.: 16.02 sN Param.: 0.54 | | Angew. Chem. Int. Ed. 2017, 56, 13279-13282 10.1002/anie.201707086 |
anion of ethyl acetylacetate (in water) |
water | N Param.: 15.99 sN Param.: 0.62 | | J. Am. Chem. Soc. 2003, 125, 12980-12986 10.1021/ja036838e |
ethyl N-acetylcarbamate anion (in DMSO) |
DMSO | N Param.: 15.99 sN Param.: 0.70 | | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 |
pyrrolidine (in 91M9AN) |
MeOH-MeCN mix | N Param.: 15.97 sN Param.: 0.63 | | Angew. Chem. Int. Ed. 2006, 45, 3869-3874 10.1002/anie.200600542 |
anion of 2-phenyl-2-(phenylsulfonyl)acetonitrile (in DMSO) |
DMSO | N Param.: 15.97 sN Param.: 0.72 | | Eur. J. Org. Chem. 2017, , 1196-1202 10.1002/ejoc.201601513 |
anion of diethyl 2-phenylmalonate (in DMSO) |
DMSO | N Param.: 15.93 sN Param.: 0.99 | | Eur. J. Org. Chem. 2016, , 1841-1848 10.1002/ejoc.201600107 |
(Z)-1-(1,3-dimesityl-4,5-dihydro-1H-imidazol-3-ium-2-yl)-2-phenylprop-1-en-1-olate (in THF) |
THF | N Param.: 15.92 sN Param.: 0.72 | | Angew. Chem. Int. Ed. 2013, 52, 11163-11167 10.1002/ange.201303524 |
1-(N-pyrrolidino)cyclopentene |
dichloromethane | N Param.: 15.91 sN Param.: 0.86 | | Chem. Eur. J. 2003, 9, 2209-2218 10.1002/chem.200204666 |
4-pyrrolidinopyridine (in CH2Cl2) |
dichloromethane | N Param.: 15.90 sN Param.: 0.67 | | Chem. Eur. J. 2007, 13, 336-345 10.1002/chem.200600941 |
4-(dimethylamino)pyridine (in THF) |
THF | N Param.: 15.90 sN Param.: 0.66 | | Angew. Chem. Int. Ed. 2011, 50, 6915-6919 10.1002/anie.201102435 |
(S)-2-(pyrrolidin-2-ylmethyl)isoindoline-1,3-dione |
MeCN | N Param.: 15.90 sN Param.: 0.77 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
Me2S=CH-CO2Et (in DMSO) |
DMSO | N Param.: 15.85 sN Param.: 0.61 | | Chem. Eur. J. 2010, 16, 8610-8614 10.1002/chem.201001455 |
anion of ethyl 2-cyano-2-phenylacetate (in DMSO) |
DMSO | N Param.: 15.85 sN Param.: 1.04 | | Eur. J. Org. Chem. 2017, , 1196-1202 10.1002/ejoc.201601513 |
o-nitrophenolate (in MeCN) |
MeCN | N Param.: 15.83 sN Param.: 0.80 | | J. Org. Chem. 2019, 84, 8837-8858 10.1021/acs.joc.9b01485 |
trifluoroacetamide anion (in DMSO) |
DMSO | N Param.: 15.81 sN Param.: 0.64 | | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 |
4-(dimethylamino)pyridine (in CH2Cl2) |
dichloromethane | N Param.: 15.80 sN Param.: 0.66 | | Chem. Eur. J. 2007, 13, 336-345 10.1002/chem.200600941 |
methanolate (in methanol) |
MeOH | N Param.: 15.78 sN Param.: 0.56 | | Can. J. Chem. 2005, 83, 1554-1560 10.1139%2Fv05-170 |
ethanolate (in ethanol) |
EtOH | N Param.: 15.78 sN Param.: 0.65 | | Can. J. Chem. 2005, 83, 1554-1560 10.1139%2Fv05-170 |
n-propylamine (in DMSO) |
DMSO | N Param.: 15.70 sN Param.: 0.64 | | J. Am. Chem. Soc. 2003, 125, 286-295 10.1021/ja021010y |
N-methyl-trifluoroacetamide anion (in DMSO) |
DMSO | N Param.: 15.70 sN Param.: 0.71 | | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 |
1-methyl-2-phenylpyrrolidine (in MeCN) |
MeCN | N Param.: 15.70 sN Param.: 0.54 | | J. Phys. Org. Chem. 2016, 29, 759-767 10.1002/poc.3580 |
N',N'-dimethylformohydrazide (in MeCN) |
MeCN | N Param.: 15.69 sN Param.: 0.51 | | J. Org. Chem. 2012, 77, 8142-8155 10.1021/jo301497g |
(4-Me2N-C6H4)-(CO)-CH=SMe2 (in DMSO) |
DMSO | N Param.: 15.68 sN Param.: 0.65 | | J. Am. Chem. Soc. 2010, 132, 17894-17900 10.1021/ja1084749 |
bis(phenylsulfonyl)methanide (in DMSO) |
DMSO | N Param.: 15.68 sN Param.: 0.74 | | Angew. Chem. Int. Ed. 2016, 55, 12845-12848 10.1002/anie.201605616 |
2-(naphthylmethyl)quinuclidine (in MeCN) |
MeCN | N Param.: 15.66 sN Param.: 0.62 | | J. Org. Chem. 2009, 74, 7157-7164 10.1021/jo901670w |
morpholine (in MeCN) |
MeCN | N Param.: 15.65 sN Param.: 0.74 | | Eur. J. Org. Chem. 2009, , 6379-6385 10.1002/ejoc.200900925 |
MeO-Breslow 1e |
THF | N Param.: 15.65 sN Param.: 0.52 | | Angew. Chem. Int. Ed. 2012, 51, 10408-10412 10.1002/anie.201204524 |
piperidine (in 91M9AN) |
MeOH-MeCN mix | N Param.: 15.63 sN Param.: 0.64 | | Angew. Chem. Int. Ed. 2006, 45, 3869-3874 10.1002/anie.200600542 |
2-phenylperoxyacetate (in H2O) |
water | N Param.: 15.63 sN Param.: 0.56 | | Angew. Chem. Int. Ed. 2017, 56, 13279-13282 10.1002/anie.201707086 |
morpholine (in water) |
water | N Param.: 15.62 sN Param.: 0.54 | | J. Org. Chem. 2007, 72, 3679-3688 10.1021/jo062586z |
anion of 4-cyanobenzyl trifluoromethyl sulfone (in MeCN) |
MeCN | N Param.: 15.62 sN Param.: 0.99 | | J. Am. Chem. Soc. 2020, 142, 8383-8402 10.1021/jacs.0c01960 |
(1H-inden-1-yl)zinc(II) bromide*LiBr (in DMSO) |
DMSO | N Param.: 15.60 sN Param.: 0.51 | | Angew. Chem. Int. Ed. 2015, 54, 12497-12500 10.1002/anie.201501385 |
TCAP (in MeCN) |
MeCN | N Param.: 15.60 sN Param.: 0.68 | | Chem. Eur. J. 2013, 19, 6435-6442 10.1002/chem.201204452 |
barbiturate anion (in DMSO) |
DMSO | N Param.: 15.59 sN Param.: 0.80 | | J. Org. Chem. 2017, 82, 8476-8488 10.1021/acs.joc.7b01223 |
Dexoxy Breslow intermediate 6 |
THF | N Param.: 15.58 sN Param.: 0.57 | | Angew. Chem. Int. Ed. 2012, 51, 10408-10412 10.1002/anie.201204524 |
anion of 2-phenylmalononitrile (in DMSO) |
DMSO | N Param.: 15.58 sN Param.: 1.00 | | Eur. J. Org. Chem. 2017, , 1196-1202 10.1002/ejoc.201601513 |
anion of ethyl cyanoacetate (in water) |
water | N Param.: 15.57 sN Param.: 0.58 | | J. Am. Chem. Soc. 2003, 125, 12980-12986 10.1021/ja036838e |
(S)-1-(pyrrolidin-2-ylmethyl)-1H-imidazole |
MeCN | N Param.: 15.55 sN Param.: 0.69 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
phthalimide anion (in DMSO) |
DMSO | N Param.: 15.52 sN Param.: 0.67 | | J. Org. Chem. 2010, 75, 5250-5258 10.1021/jo1009883 |
4-(dimethylamino)pyridine (in MeCN) |
MeCN | N Param.: 15.51 sN Param.: 0.62 | | J. Phys. Chem. A 2012, 116, 8494-8499 10.1021/jp3049247 |
diethanolamine (in DMSO) |
DMSO | N Param.: 15.51 sN Param.: 0.70 | | J. Am. Chem. Soc. 2009, 131, 11392-11401 10.1021/ja903207b |
DBN (in CH2Cl2) |
dichloromethane | N Param.: 15.50 sN Param.: 0.76 | | ChemCatChem 2012, 4, 993-999 10.1002/cctc.201200143 |
tri-n-butylphosphane |
dichloromethane | N Param.: 15.49 sN Param.: 0.69 | | Chem. Eur. J. 2005, 11, 917-927 10.1002/chem.200400696 |
o-nitrophenolate (in DMSO) |
DMSO | N Param.: 15.48 sN Param.: 0.71 | | J. Org. Chem. 2019, 84, 8837-8858 10.1021/acs.joc.9b01485 |
1-aminopropan-2-ol (in DMSO) |
DMSO | N Param.: 15.47 sN Param.: 0.65 | | J. Am. Chem. Soc. 2009, 131, 11392-11401 10.1021/ja903207b |
tris(4-methylphenyl)phosphane |
dichloromethane | N Param.: 15.44 sN Param.: 0.64 | | Chem. Eur. J. 2005, 11, 917-927 10.1002/chem.200400696 |
(S)-2-(azidomethyl)pyrrolidine |
MeCN | N Param.: 15.43 sN Param.: 0.73 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
HOO- (in water) |
water | N Param.: 15.40 sN Param.: 0.55 | | J. Am. Chem. Soc. 2003, 125, 286-295 10.1021/ja021010y |
morpholine (in 91M9AN) |
MeOH-MeCN mix | N Param.: 15.40 sN Param.: 0.64 | | Angew. Chem. Int. Ed. 2006, 45, 3869-3874 10.1002/anie.200600542 |
2-Ac super-dmap (in MeCN) |
MeCN | N Param.: 15.39 sN Param.: 0.60 | | Org. Lett. 2011, 13, 530-533 10.1021/ol1029589 |
(Z)-1-(1,3-dimesityl-1H-imidazol-3-ium-2-yl)-2-phenylprop-1-en-1-olate (in THF) |
THF | N Param.: 15.33 sN Param.: 0.79 | | Angew. Chem. Int. Ed. 2013, 52, 11163-11167 10.1002/ange.201303524 |
anion of triethyl methanetricarboxylate (in DMSO) |
DMSO | N Param.: 15.33 sN Param.: 0.72 | | Eur. J. Org. Chem. 2016, , 1841-1848 10.1002/ejoc.201600107 |
(S)-4-phenyl-1-(pyrrolidin-2-ylmethyl)-1H-1,2,3-triazole |
MeCN | N Param.: 15.32 sN Param.: 0.72 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
p-nitrobenzoate (in MeCN) |
MeCN | N Param.: 15.30 sN Param.: 0.76 | | J. Am. Chem. Soc. 2008, 130, 3012-3022 10.1021/ja0765464 |
(R)-2-benzhydryl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine |
dichloromethane | N Param.: 15.30 sN Param.: 0.55 | | J. Org. Chem. 2011, 76, 5104-5112 10.1021/jo200803x |
DBU (in MeCN) |
MeCN | N Param.: 15.29 sN Param.: 0.70 | | Chem. Commun. 2008, , 1792-1794 10.1039/b801811a |
benzylamine (in DMSO) |
DMSO | N Param.: 15.28 sN Param.: 0.65 | | J. Am. Chem. Soc. 2009, 131, 11392-11401 10.1021/ja903207b |
n-butylamine (in MeCN) |
MeCN | N Param.: 15.27 sN Param.: 0.63 | | Eur. J. Org. Chem. 2009, , 6379-6385 10.1002/ejoc.200900925 |
3-pyrrolidino-1H-indene (in MeCN) |
MeCN | N Param.: 15.27 sN Param.: 0.93 | | Synthesis 2019, 51, 1157-1170 10.1055/s-0037-1611634 |
anion of ethyl 2-nitroacetate (in DMSO) |
DMSO | N Param.: 15.24 sN Param.: 0.74 | | Chem. Eur. J. 2015, 21, 875-884 10.1002/chem.201404500 |
2-methyl-1,4,5,6-tetrahydropyrimidine (in CH2Cl2) |
dichloromethane | N Param.: 15.21 sN Param.: 0.69 | | Eur. J. Org. Chem. 2013, , 3369-3377 10.1002/ejoc.201300213 |
4-aminopyridine (in CH2Cl2) |
dichloromethane | N Param.: 15.20 sN Param.: 0.67 | | Chem. Eur. J. 2007, 13, 336-345 10.1002/chem.200600941 |
(S)-N-propylpyrrolidine-2-carboxamide |
MeCN | N Param.: 15.20 sN Param.: 0.73 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
methylamine (in MeCN) |
MeCN | N Param.: 15.19 sN Param.: 0.68 | | J. Org. Chem. 2012, 77, 8142-8155 10.1021/jo301497g |
tris(2,6-dimethoxyphenyl)phosphane |
dichloromethane | N Param.: 15.19 sN Param.: 0.88 |  | Chem. Eur. J. 2017, 23, 7422-7427 10.1002/chem.201701080 |
KBH4 (in DMSO) |
DMSO | N Param.: 15.14 sN Param.: 0.77 | | Angew. Chem. Int. Ed. 2009, 48, 1958-1961 10.1002/anie.200804263 |
p-nitrophenolate (in MeCN) |
MeCN | N Param.: 15.14 sN Param.: 0.82 | | J. Org. Chem. 2019, 84, 8837-8858 10.1021/acs.joc.9b01485 |
5-(4-(methoxy)benzyl)-2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ide (in DMSO) |
DMSO | N Param.: 15.13 sN Param.: 0.75 | | Chem. Eur. J. 2014, 20, 11069-11077 10.1002/chem.201403161 |
n-propylamine (in MeCN) |
MeCN | N Param.: 15.11 sN Param.: 0.63 | | Eur. J. Org. Chem. 2009, , 6379-6385 10.1002/ejoc.200900925 |
diethylamine (in MeCN) |
MeCN | N Param.: 15.10 sN Param.: 0.73 | | Eur. J. Org. Chem. 2009, , 6379-6385 10.1002/ejoc.200900925 |
anion of (phenylmethylenedisulfonyl)dibenzene (in DMSO) |
DMSO | N Param.: 15.07 sN Param.: 0.79 | | Eur. J. Org. Chem. 2017, , 1196-1202 10.1002/ejoc.201601513 |
1-(N-piperidino)cyclopentene |
dichloromethane | N Param.: 15.06 sN Param.: 0.82 | | Chem. Eur. J. 2003, 9, 2209-2218 10.1002/chem.200204666 |
p-nitrophenolate (in DMF) |
DMF | N Param.: 15.05 sN Param.: 0.80 | | J. Org. Chem. 2019, 84, 8837-8858 10.1021/acs.joc.9b01485 |
purine anion (in DMSO) |
DMSO | N Param.: 15.03 sN Param.: 0.77 | | Chem. Eur. J. 2012, 18, 127-137 10.1002/chem.201102411 |
5-benzyl-2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ide (in DMSO) |
DMSO | N Param.: 15.02 sN Param.: 0.75 | | Chem. Eur. J. 2014, 20, 11069-11077 10.1002/chem.201403161 |
azide ion (in 45M55AN) |
MeOH-MeCN mix | N Param.: 15.01 sN Param.: 0.80 | | J. Phys. Org. Chem. 2006, 19, 706-713 10.1002/poc.1063 |
anion of 1,2,3-triphenylpropane-1,3-dione (in DMSO) |
DMSO | N Param.: 14.99 sN Param.: 0.83 | | Eur. J. Org. Chem. 2017, , 1196-1202 10.1002/ejoc.201601513 |
4-pyrrolidinopyridine (in MeCN) |
MeCN | N Param.: 14.99 sN Param.: 0.69 | | Chem. Eur. J. 2013, 19, 6435-6442 10.1002/chem.201204452 |
(S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyrrolidin-2-ylmethyl)thiourea |
MeCN | N Param.: 14.97 sN Param.: 0.69 | | J. Am. Chem. Soc. 2020, 142, 1526-1547 10.1021/jacs.9b11877 |
methyl (cyclohexen-1-yl)prolinate (in MeCN) |
MeCN | N Param.: 14.96 sN Param.: 0.68 | | Angew. Chem. Int. Ed. 2010, 49, 9526-9529 10.1002/anie.201004344 |
(2S,3S)-3-isopropyl-2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine |
dichloromethane | N Param.: 14.96 sN Param.: 0.64 | | J. Org. Chem. 2011, 76, 5104-5112 10.1021/jo200803x |